Alt Solunum Yolu Enfeksiyonu Geçiren 1-24 Ay Arası Çocuklarda Serum 25(OH)D Vitamini Düzeyleri

Abstract

Amaç: Bu çalışmada; 1-24 ay arası çocuklarda serum D vitamini düzeylerinin alt solunum yolu enfeksiyonu (ASYE) ile ilişkisinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Eylül 2010 ile Eylül 2013 tarihleri arasında, hastanemizin çocuk polikliniklerine başvuran 1-24 ay arası ASYE tanısı alan 31 hasta çocuk ile aynı yaş grubunda kronik hastalığı olmayan ve ASYE geçirmeyen 33 çocuk olmak üzere toplam 64 çocuk alındı. Hastaların ve kontrol grubundaki olguların serum 25(OH)D vitamini düzeyleri ELISA yöntemiyle ölçüldü. Bulgular: Çalışmamızda; alt solunum yolu enfeksiyonu geçiren çocukların serum 25(OH)D vitamini düzeyleri kontrol grubuna göre daha düşük bulundu (p<0,001). Gebelik boyunca annenin ve sonrasında bebeklerin düzenli D vitamini kullanımı ile ASYE arasında anlamlı bir ilişki saptandı. Annenin giyim şekli, çocuğun anne sütü alımı, dışarıda zaman geçirme süresi, cinsiyeti ve ASYE geçirme sayısı ile serum 25(OH)D vitamini arasında anlamlı bir ilişki saptanmadı. Tartışma: ASYE geçiren 1-24 ay arası çocukların serum 25(OH)D vitamini düzeyleri sağlıklı çocuklara göre anlamlı olarak düşük bulunmuştur. Sonuç: Enfeksiyonlara karşı savunmada önemli rolü olan D vitamininin hangi düzeyin altında savunma sistemini zayıflattığını belirleyebilmek için vaka sayısının daha fazla olduğu klinik-etkinlik araştırmalarına ihtiyaç vardır

Keywords

• Alt solunum yolu enfeksiyonu
• D vitamini
• süt çocuğu

Serum 25(OH) Vitamin D Levels in Children Between 1 to 24 Months of Age with Previous Lower Respiratory Tract Infection

Abstract

Objective: The aim of this study was to investigate the relationship between lower respiratory tract infection (LRTI) and the level of serum vitamin D in infants aged 1-24 months. Material and Method: The sample in this study included a total of 64 infants consisting of 31 infants aged 1 to 24 months and diagnosed with LRTI at the pediatric policlinics of our hospital and 33 infants of the same age range and diagnosed with neither a chronic disease nor LRTI. The levels of serum 25(OH) vitamin D in patients and cases in control group were measured with ELISA. Results: In the study, it was found that levels of serum 25(OH) vitamin D in patients with LRTI were lower than control group (p<0.001). A significant relationship was found between LRTI and regular use of vitamin D by the mother during pregnancy and by the baby postnatally. A significant relationship was not found between serum 25(OH) vitamin D and the clothing style of mother, breastfeeding, time spent outdoors, sex, or number of instances of LRTI. Discussion: The levels of serum 25(OH) vitamin D in infants aged 1-24 months with LRTI was found to be significantly low compared to healthy infants. Conclusion: There is a need for clinical effectiveness studies with a higher number of cases in order to determine under which level of the vitamin D, which plays a critical role in defense against infections, weakens the defense system.

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