Etiologic Evaluation of Severe Short Stature in Children at a Tertiary Pediatric Endocrinology Centre

Utkucan Uçkun; Firdevs Baş; Şükran Poyrazoğlu; Mine Şükür; Feyza Darendeliler; Rüveyde Bundak

doi:10.5222/j.child.2019.18942

Üçüncü Basamak Bir Pediatrik Endokrinoloji Merkezinde İzlenen Ağır Boy Kısalığı Vakalarının Etiyolojik Değerlendirmesi

Year 2019, Volume: 19 Issue: 2, 63 - 76, 01.07.2019

Utkucan Uçkun Firdevs Baş Şükran Poyrazoğlu Mine Şükür Feyza Darendeliler Rüveyde Bundak

https://doi.org/10.5222/j.child.2019.18942

https://izlik.org/JA92WR56DL

Abstract

Objective: The aim of this study was to describe the characteristics and the etiological profile of children with severe short stature evaluated at a tertiary Pediatric Endocrinology centre in Istanbul. Method: Randomly selected 500 patients with the diagnosis of severe short stature height SDS

Keywords

Ağır boy kısalığı , çocuklar , etiyoloji , büyüme hormonu eksikliği

References

1. Sen Y, Bozdag S. The etiological distribution of patients admitted to the pediatric endocrinology clinic. Fırat University Journals of Health Sciences 2008;22(2): 53-8.
2. Rosenfield R, Cuttler L. Short stature. In: DeGroot LJ, Jamesan JL, eds. Endocrinology. 4th ed. Philadelphia: WB Saunders, 2001:485-94.
3. Marcovitch H. Failure to thrive. Br Med J. 1994;308: 35-8. https://doi.org/10.1136/bmj.308.6920.35
4. Frindik JP, Kemp SF, Hunold JJ. Near adult heights after growth hormone treatment in patients with idiopathic short stature or idiopathic growth hormone deficiency. J Pediatr Endocrinol Metab 2003;16:607-12.
5. Vogiatazi MG, Copland KC. The short child. Pediatr Rev 1998;19:92-9.
6. Thomas Aceto JR, Dempsher D. Short stature and slow growth in the young. In: Becker KL, eds. Principles and Practice of Endocrinology and Metabolism. 3rd ed. Philadelphia: Lippincott Williams and Wilkins, 2001:1784-97.
7. Rosenfeld RG. Growth retardation. In: Sperling MA, eds. Pediatric Endocrinology. Philadelphia: WB Saunders, 1996:135-57.
8. Reiter O, Rosenfeld Ron G. Growth retardation. In: Williams RH, Wilson JD, eds. Williams Textbook of Endocrinology. 9th ed. Philadelphia: WB Saunders, 1998:1453-8.
9. Jan M Wit. International Classification of Pediatric Endocrine Diagnoses. Horm Res Paediatr. 2016;86(3): 212-4. https://doi.org/10.1159/000448893
10. American Academy of Pediatrics. Recommendations for Preventive Pediatric Health Care Committee on Practice and Ambulatory Medicine. Pediatrics 2000;105:645-6. https://doi.org/10.1542/peds.105.3.645
11. Lacey KA, Parkin JM. Causes of short stature. A community study of children in Newcastle upon Tyne. Lancet 1974;1(7846):42-5. https://doi.org/10.1016/S0140-6736(74)93041-4
12. Voss LD. Growth hormone therapy for the short normal child: who needs it and who wants it? The case against growth hormone therapy. J. Pediatr. 2000;136:103-6. https://doi.org/10.1016/S0022-3476(00)90058-1
13. Voss LD, Mulligan J, Betts PR, Wilkin TJ. Poor growth in school entrants as an index of organic disease: the Wessex growth study. BMJ 1992;305:1400-2. https://doi.org/10.1136/bmj.305.6866.1400
14. Zafer Y, Kandemir N, Yordam N. Etiological distribution of short stature: Evaluation of 1013 cases. Journal of Child Health and Diseases 1999;42:205-13.
15. Demirel F, Bideci B, Camurdan MO, Arga M, Cinaz P. Etiological causes of short stature in children. Turkish Archives of Pediatrics 2005;40(1):39-43.
16. Fenton TR, Kim JH. A systematic review and metaanalysis to revise the Fenton growth chart for preterm infants. BMC Pediatr. 2013;13:59. https://doi.org/10.1186/1471-2431-13-59
17. Neyzi O, Bundak R, Darendeliler F, Günöz H. Büyüme Gelişme ve Bozuklukları. In: Neyzi O, Ertuğrul T, eds. Pediyatri Cilt 1, 4th ed, Istanbul: Nobel Tıp Kitapevleri, 2010:89-149.
18. Marshall WA, Tanner JM. Variations in pattern of pubrtal changes in girls. Arch Dis Child. 1969;44:291-303. https://doi.org/10.1136/adc.44.235.291
19. Marshall WA, Tanner JM. Variations in pattern of pubrtal changes in boys. Arch Dis Child. 1970;45:13-23.
20. Bundak R, Furman A, Gunoz H, Darendeliler F, Bas F, Neyzi O. Body mass index for Turkish children aged 6 to 18 years. Acta Paediatr 2006;95:194-8. https://doi.org/10.1080/08035250500334738
21. Neyzi O, Furman A, Bundak R, Gunoz H, Darendeliler F, Bas F. Growth references for Turkish children aged 6 to 18 years. Acta Paediatr. 2006;95:1635-41. https://doi.org/10.1080/08035250600652013
22. Neyzi O, Gunoz H, Furman A, Türk çocuklarında vücut ağırlığı, boy uzunluğu, baş çevresi ve vücut kitle indeksi referans değerleri. Çocuk Sağlığı ve Hastalıkları Dergisi 2008;51:1-14.
23. WHO Multicentre Growth Reference Study Group. WHO Child Growth Standards Acta Paediatrica Supplement 2006;450.
24. De Onis M, Onyango AW, Borghi E, Siyam A, Nishida C, Siekmann J. Development of a WHO growth reference for school-aged children and adolescents. Bulletin of the World Health Organization, 2007;85(9):649-732. https://doi.org/10.2471/BLT.07.043497
25. McLaren DS, Read WWC. Classification of nutritional status in early childhood. Lancet 1972;2(7769):146-8. https://doi.org/10.1016/S0140-6736(72)91324-4
26. Tanner JM, Goldstein H, Whitwhouse RH. Standards for children’s height at age 2-9 years allowing for height of parents. Arch Dis Child. 1970;45:755-62. https://doi.org/10.1136/adc.45.244.755
27. Bayley N, Pinneau SR. Tables for predicting adult height from skeletal age: revised for use with the GreulichPyle hand standart. J Pediatr. 1952;40:423-41. https://doi.org/10.1016/S0022-3476(52)80205-7
28. Şükür M, Baş F, Darendeliler F ve ark. Pediatrik endokrinoloji polikliniğine müracaat eden hastaların etiyolojik dağılımı: pilot çalışma. Pediatrik Endokrinoloji Kongresi Bildiri Özet Kitabı, 14-17 Eylül 2006, Konya, 2006:140.
29. Lindsay R, Feldkamp M, Harris D, Robertson J, Rallison M. Utah Growth Study: growth standards and the prevalence of growth hormone deficiency. J Pediatr. 1994;125:29-35. https://doi.org/10.1016/S0022-3476(94)70117-2
30. Song KC, Jin SL, Kwon AR, Chae HW, Ahn JM, Kim DH, et al. Etiologies and characteristics of children with chief complaint of short stature. Ann Pediatr Endocrinol Metab. 2015;20:34-9. https://doi.org/10.6065/apem.2015.20.1.34
31. Strufaldi MWL, da Silva EMK, Puccini RF. Follow-up of children and adolescents with short stature: the importance of the growth rate. Sao Paulo Med J. 2005;123(3):128-33. https://doi.org/10.1590/S1516-31802005000300008
32. Shiva S, Nikzad A. Etiology of short stature in East Azerbaijan, Iran. Iran J Pediatr. 2009;19:35-40.
33. Moayeri H, Aghighi Y. A prospective study of etiology of short stature in 426 short children and adolescents. Arch Iranian Med. 2004;7:23-7.
34. Lashari SK, Korejo HB, Memon YM. To determine frequency of etiological factors in short statured patients presenting at an endocrine clinic of a tertiary care hospital. Pak J Med Sci. 2014;30:858-61. https://doi.org/10.12669/pjms.304.4619
35. Zargar AH, Laway BA, Masoodi SR. An aetiological profile of short stature in the Indian subcontinent. J Pediatr Child Health. 1998;34:571-6. https://doi.org/10.1046/j.1440-1754.1998.00308.x
36. Papadimitriou A, Douros K, Papadimitriou DT, Kleanthous K, Karapanou O, Fretzayas A. Characteristics of the short children referred to an academic paediatric endocrine clinic in Greece. J Paediatr Child Health. 2012;48:263-7. https://doi.org/10.1111/j.1440-1754.2011.02256.x
37. Bhadada SK, Bhansali A, Ravikumar P, Kochhar R, Nain CK, Dutta P, et al. Changing scenario in aetiological profile of short stature in India-growing importance of celiac disease: a study from tertiary care centre. Indian J Pediatr. 2011;78(1):41-4. https://doi.org/10.1007/s12098-010-0227-6
38. Tunçbilek E, Özgüç M. Application of medical genetics in Turkey. The Turkish Journal of Pediatrics 2007;49: 353-9.
39. Binder G. Short stature due to SHOX deficiency: Genotype, phenotype, and therapy. Horm Res Paediatr. 2011;75:81-89. https://doi.org/10.1159/000324105
40. Saenger P, Czernichow P, Hughes I, Reiter EO. Small for gestational age: Short stature and beyond. Endocr Rev. 2007;28(2):219-51. https://doi.org/10.1210/er.2006-0039
41. Chernausek SD. Mendelian genetic causes of the short child born small for gestational age. J Endocrinol Invest. 2006;29(1):16-20.
42. Jee YH. Genetics of Short Stature. Endocrinol Metab Clin North Am. 2017;46(2):259-81. https://doi.org/10.1016/j.ecl.2017.01.001

Etiologic Evaluation of Severe Short Stature in Children at a Tertiary Pediatric Endocrinology Centre

Year 2019, Volume: 19 Issue: 2, 63 - 76, 01.07.2019

Utkucan Uçkun Firdevs Baş Şükran Poyrazoğlu Mine Şükür Feyza Darendeliler Rüveyde Bundak

https://doi.org/10.5222/j.child.2019.18942

https://izlik.org/JA92WR56DL

Abstract

Amaç: Araştırmamızın amacı İstanbul’da üçüncü basamak bir Pediatrik Endokrinoloji merkezinde izlenen ağır boy kısalığı olgularının etiyolojik profilini ve karakteristiklerini incelemektir. Yöntem: Rastgele seçilen 500 ağır boy kısalığı boy SDS

Keywords

Severe short stature , children , etiology , growth hormone deficincy

References

1. Sen Y, Bozdag S. The etiological distribution of patients admitted to the pediatric endocrinology clinic. Fırat University Journals of Health Sciences 2008;22(2): 53-8.
2. Rosenfield R, Cuttler L. Short stature. In: DeGroot LJ, Jamesan JL, eds. Endocrinology. 4th ed. Philadelphia: WB Saunders, 2001:485-94.
3. Marcovitch H. Failure to thrive. Br Med J. 1994;308: 35-8. https://doi.org/10.1136/bmj.308.6920.35
4. Frindik JP, Kemp SF, Hunold JJ. Near adult heights after growth hormone treatment in patients with idiopathic short stature or idiopathic growth hormone deficiency. J Pediatr Endocrinol Metab 2003;16:607-12.
5. Vogiatazi MG, Copland KC. The short child. Pediatr Rev 1998;19:92-9.
6. Thomas Aceto JR, Dempsher D. Short stature and slow growth in the young. In: Becker KL, eds. Principles and Practice of Endocrinology and Metabolism. 3rd ed. Philadelphia: Lippincott Williams and Wilkins, 2001:1784-97.
7. Rosenfeld RG. Growth retardation. In: Sperling MA, eds. Pediatric Endocrinology. Philadelphia: WB Saunders, 1996:135-57.
8. Reiter O, Rosenfeld Ron G. Growth retardation. In: Williams RH, Wilson JD, eds. Williams Textbook of Endocrinology. 9th ed. Philadelphia: WB Saunders, 1998:1453-8.
9. Jan M Wit. International Classification of Pediatric Endocrine Diagnoses. Horm Res Paediatr. 2016;86(3): 212-4. https://doi.org/10.1159/000448893
10. American Academy of Pediatrics. Recommendations for Preventive Pediatric Health Care Committee on Practice and Ambulatory Medicine. Pediatrics 2000;105:645-6. https://doi.org/10.1542/peds.105.3.645
11. Lacey KA, Parkin JM. Causes of short stature. A community study of children in Newcastle upon Tyne. Lancet 1974;1(7846):42-5. https://doi.org/10.1016/S0140-6736(74)93041-4
12. Voss LD. Growth hormone therapy for the short normal child: who needs it and who wants it? The case against growth hormone therapy. J. Pediatr. 2000;136:103-6. https://doi.org/10.1016/S0022-3476(00)90058-1
13. Voss LD, Mulligan J, Betts PR, Wilkin TJ. Poor growth in school entrants as an index of organic disease: the Wessex growth study. BMJ 1992;305:1400-2. https://doi.org/10.1136/bmj.305.6866.1400
14. Zafer Y, Kandemir N, Yordam N. Etiological distribution of short stature: Evaluation of 1013 cases. Journal of Child Health and Diseases 1999;42:205-13.
15. Demirel F, Bideci B, Camurdan MO, Arga M, Cinaz P. Etiological causes of short stature in children. Turkish Archives of Pediatrics 2005;40(1):39-43.
16. Fenton TR, Kim JH. A systematic review and metaanalysis to revise the Fenton growth chart for preterm infants. BMC Pediatr. 2013;13:59. https://doi.org/10.1186/1471-2431-13-59
17. Neyzi O, Bundak R, Darendeliler F, Günöz H. Büyüme Gelişme ve Bozuklukları. In: Neyzi O, Ertuğrul T, eds. Pediyatri Cilt 1, 4th ed, Istanbul: Nobel Tıp Kitapevleri, 2010:89-149.
18. Marshall WA, Tanner JM. Variations in pattern of pubrtal changes in girls. Arch Dis Child. 1969;44:291-303. https://doi.org/10.1136/adc.44.235.291
19. Marshall WA, Tanner JM. Variations in pattern of pubrtal changes in boys. Arch Dis Child. 1970;45:13-23.
20. Bundak R, Furman A, Gunoz H, Darendeliler F, Bas F, Neyzi O. Body mass index for Turkish children aged 6 to 18 years. Acta Paediatr 2006;95:194-8. https://doi.org/10.1080/08035250500334738
21. Neyzi O, Furman A, Bundak R, Gunoz H, Darendeliler F, Bas F. Growth references for Turkish children aged 6 to 18 years. Acta Paediatr. 2006;95:1635-41. https://doi.org/10.1080/08035250600652013
22. Neyzi O, Gunoz H, Furman A, Türk çocuklarında vücut ağırlığı, boy uzunluğu, baş çevresi ve vücut kitle indeksi referans değerleri. Çocuk Sağlığı ve Hastalıkları Dergisi 2008;51:1-14.
23. WHO Multicentre Growth Reference Study Group. WHO Child Growth Standards Acta Paediatrica Supplement 2006;450.
24. De Onis M, Onyango AW, Borghi E, Siyam A, Nishida C, Siekmann J. Development of a WHO growth reference for school-aged children and adolescents. Bulletin of the World Health Organization, 2007;85(9):649-732. https://doi.org/10.2471/BLT.07.043497
25. McLaren DS, Read WWC. Classification of nutritional status in early childhood. Lancet 1972;2(7769):146-8. https://doi.org/10.1016/S0140-6736(72)91324-4
26. Tanner JM, Goldstein H, Whitwhouse RH. Standards for children’s height at age 2-9 years allowing for height of parents. Arch Dis Child. 1970;45:755-62. https://doi.org/10.1136/adc.45.244.755
27. Bayley N, Pinneau SR. Tables for predicting adult height from skeletal age: revised for use with the GreulichPyle hand standart. J Pediatr. 1952;40:423-41. https://doi.org/10.1016/S0022-3476(52)80205-7
28. Şükür M, Baş F, Darendeliler F ve ark. Pediatrik endokrinoloji polikliniğine müracaat eden hastaların etiyolojik dağılımı: pilot çalışma. Pediatrik Endokrinoloji Kongresi Bildiri Özet Kitabı, 14-17 Eylül 2006, Konya, 2006:140.
29. Lindsay R, Feldkamp M, Harris D, Robertson J, Rallison M. Utah Growth Study: growth standards and the prevalence of growth hormone deficiency. J Pediatr. 1994;125:29-35. https://doi.org/10.1016/S0022-3476(94)70117-2
30. Song KC, Jin SL, Kwon AR, Chae HW, Ahn JM, Kim DH, et al. Etiologies and characteristics of children with chief complaint of short stature. Ann Pediatr Endocrinol Metab. 2015;20:34-9. https://doi.org/10.6065/apem.2015.20.1.34
31. Strufaldi MWL, da Silva EMK, Puccini RF. Follow-up of children and adolescents with short stature: the importance of the growth rate. Sao Paulo Med J. 2005;123(3):128-33. https://doi.org/10.1590/S1516-31802005000300008
32. Shiva S, Nikzad A. Etiology of short stature in East Azerbaijan, Iran. Iran J Pediatr. 2009;19:35-40.
33. Moayeri H, Aghighi Y. A prospective study of etiology of short stature in 426 short children and adolescents. Arch Iranian Med. 2004;7:23-7.
34. Lashari SK, Korejo HB, Memon YM. To determine frequency of etiological factors in short statured patients presenting at an endocrine clinic of a tertiary care hospital. Pak J Med Sci. 2014;30:858-61. https://doi.org/10.12669/pjms.304.4619
35. Zargar AH, Laway BA, Masoodi SR. An aetiological profile of short stature in the Indian subcontinent. J Pediatr Child Health. 1998;34:571-6. https://doi.org/10.1046/j.1440-1754.1998.00308.x
36. Papadimitriou A, Douros K, Papadimitriou DT, Kleanthous K, Karapanou O, Fretzayas A. Characteristics of the short children referred to an academic paediatric endocrine clinic in Greece. J Paediatr Child Health. 2012;48:263-7. https://doi.org/10.1111/j.1440-1754.2011.02256.x
37. Bhadada SK, Bhansali A, Ravikumar P, Kochhar R, Nain CK, Dutta P, et al. Changing scenario in aetiological profile of short stature in India-growing importance of celiac disease: a study from tertiary care centre. Indian J Pediatr. 2011;78(1):41-4. https://doi.org/10.1007/s12098-010-0227-6
38. Tunçbilek E, Özgüç M. Application of medical genetics in Turkey. The Turkish Journal of Pediatrics 2007;49: 353-9.
39. Binder G. Short stature due to SHOX deficiency: Genotype, phenotype, and therapy. Horm Res Paediatr. 2011;75:81-89. https://doi.org/10.1159/000324105
40. Saenger P, Czernichow P, Hughes I, Reiter EO. Small for gestational age: Short stature and beyond. Endocr Rev. 2007;28(2):219-51. https://doi.org/10.1210/er.2006-0039
41. Chernausek SD. Mendelian genetic causes of the short child born small for gestational age. J Endocrinol Invest. 2006;29(1):16-20.
42. Jee YH. Genetics of Short Stature. Endocrinol Metab Clin North Am. 2017;46(2):259-81. https://doi.org/10.1016/j.ecl.2017.01.001

There are 42 citations in total.

Details

Primary Language	English
Authors	Utkucan Uçkun This is me Firdevs Baş This is me Şükran Poyrazoğlu This is me Mine Şükür This is me Feyza Darendeliler This is me Rüveyde Bundak This is me
Publication Date	July 1, 2019
DOI	https://doi.org/10.5222/j.child.2019.18942
IZ	https://izlik.org/JA92WR56DL
Published in Issue	Year 2019 Volume: 19 Issue: 2

Cite

APA	Uçkun, U., Baş, F., Poyrazoğlu, Ş., Şükür, M., Darendeliler, F., & Bundak, R. (2019). Etiologic Evaluation of Severe Short Stature in Children at a Tertiary Pediatric Endocrinology Centre. Çocuk Dergisi, 19(2), 63-76. https://doi.org/10.5222/j.child.2019.18942
AMA	1.Uçkun U, Baş F, Poyrazoğlu Ş, Şükür M, Darendeliler F, Bundak R. Etiologic Evaluation of Severe Short Stature in Children at a Tertiary Pediatric Endocrinology Centre. Çocuk Dergisi. 2019;19(2):63-76. doi:10.5222/j.child.2019.18942
Chicago	Uçkun, Utkucan, Firdevs Baş, Şükran Poyrazoğlu, Mine Şükür, Feyza Darendeliler, and Rüveyde Bundak. 2019. “Etiologic Evaluation of Severe Short Stature in Children at a Tertiary Pediatric Endocrinology Centre”. Çocuk Dergisi 19 (2): 63-76. https://doi.org/10.5222/j.child.2019.18942.
EndNote	Uçkun U, Baş F, Poyrazoğlu Ş, Şükür M, Darendeliler F, Bundak R (July 1, 2019) Etiologic Evaluation of Severe Short Stature in Children at a Tertiary Pediatric Endocrinology Centre. Çocuk Dergisi 19 2 63–76.
IEEE	[1]U. Uçkun, F. Baş, Ş. Poyrazoğlu, M. Şükür, F. Darendeliler, and R. Bundak, “Etiologic Evaluation of Severe Short Stature in Children at a Tertiary Pediatric Endocrinology Centre”, Çocuk Dergisi, vol. 19, no. 2, pp. 63–76, July 2019, doi: 10.5222/j.child.2019.18942.
ISNAD	Uçkun, Utkucan - Baş, Firdevs - Poyrazoğlu, Şükran - Şükür, Mine - Darendeliler, Feyza - Bundak, Rüveyde. “Etiologic Evaluation of Severe Short Stature in Children at a Tertiary Pediatric Endocrinology Centre”. Çocuk Dergisi 19/2 (July 1, 2019): 63-76. https://doi.org/10.5222/j.child.2019.18942.
JAMA	1.Uçkun U, Baş F, Poyrazoğlu Ş, Şükür M, Darendeliler F, Bundak R. Etiologic Evaluation of Severe Short Stature in Children at a Tertiary Pediatric Endocrinology Centre. Çocuk Dergisi. 2019;19:63–76.
MLA	Uçkun, Utkucan, et al. “Etiologic Evaluation of Severe Short Stature in Children at a Tertiary Pediatric Endocrinology Centre”. Çocuk Dergisi, vol. 19, no. 2, July 2019, pp. 63-76, doi:10.5222/j.child.2019.18942.
Vancouver	1.Uçkun U, Baş F, Poyrazoğlu Ş, Şükür M, Darendeliler F, Bundak R. Etiologic Evaluation of Severe Short Stature in Children at a Tertiary Pediatric Endocrinology Centre. Çocuk Dergisi [Internet]. 2019 July 1;19(2):63-76. Available from: https://izlik.org/JA92WR56DL

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