Akut Lenfoblastik Lösemili Üç yaşında Bir Çocukta İnvaziv Mantar Enfeksiyonunun Posakonazol ile Başarılı Tedavisi

Year 2018, , 144 - 149, 01.10.2018

Nihal Özdemir Başak Koç Serda Kantarcıoğlu Sebuh Kuruoğlu Tiraje Celkan

https://doi.org/10.5222/j.child.2018.99705

Abstract

İnvaziv mantar enfeksiyonları, özellikle albicans dışı Candida gibi mayalar, artan immün-baskılanmış hasta sayısı ve oluşan mantar direnci nedeniyle artış göster- mektedir. Son on yılda bu enfeksiyonların tedavisi için yeni antifungal ilaçlar geliştirilmiştir. Bu yazıda akut lenfoblastik lösemili 3 yaşında bir kız çocukta Candida albicans’a bağlı gelişen invazif kandida enfeksiyonu bil- dirilmiştir. Lipozomal amfoterisin B, kaspofungin ve vori- konazolün tek başına ve bu ilaçların birlikte tedavisine rağmen hastanın ateşi ve klinik durumunda düzelme olmamış, tedaviye posakonazol eklenmesiyle düzelme görülmüştür. Devam tedavisi sırasında mantar enfeksiyo- nu kontrol altında kalmış ve posakonazol profilaksisi altında tekrarlamamıştır

Keywords

Candida albicans, mantar enfeksiyonu, antifungal

Akut Lenfoblastik Lösemili Üç yaşında Bir Çocukta İnvaziv Mantar Enfeksiyonunun Posakonazol ile Başarılı Tedavisi

Abstract

Invasive fungal infections, especially non-Candida albicans, are increasing because of the increasing number of immuno- compromised patients and resistance to fungal infectons. New drugs for the treatment of antifungal infections have been developed in the last decade. We report a 3-year-old girl with acute lymphoblastic leukemia who developed inva- sive Candida infection caused by Candida albicans. Despite single and combined therapy with liposomal amphotericin B, caspofungin and voriconazole, patient’s fever and clinical condition were improved only after addition of posaconazole to the treatment. During maintenance therapy BFM-95 ALL treatment for standard risk group for ALL, fungal infection remained under control and did not recur under posacon- azole prophylaxis

Keywords

Candida albicans, fungal infection, anti-fungal

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