Hışıltılı Bebeklerde Serum Lösemi İnhibitör Faktör LIF Düzeyleri ve Respiratuar Sinsisyal Virüs Enfeksiyonuyla İlişkisi

Year 2017, , 12 - 17, 01.01.2017

Zeynep Tamay Kemal Nişli Nermin Güler Deniz Özçeker Ülker Öneş

https://doi.org/10.5222/j.child.2017.012

Abstract

Amaç: Lösemi inhibitör faktör sitokinlerin interlökin-6 ailesinin en pleiotropik üyesidir. LIF reseptör β ve gp130’yi içeren bir reseptörü kullanır. Bu reseptör kompleksi aynı zamanda siliyer nötrofilik büyüme faktörü CTNF ,onkostatin M, kardiotrofin e benzer sitokin CLC tarafından da kullanılmaktadır. LIF’nin havayolu enflamasyonunda da önemli bir rol oynayabildiğine ilişkin kanıtlar ortaya çıkmaktadır. Erken çocukluk döneminde en çok görülen sorunlardan biri yinelenen hışıltılar ve hışıltı ataklarının en sık görülen nedeni respiratuar sinsisyal virüstür RSV .Gereç ve Yöntem: Bu çalışmanın amacı LIF’in hışıltılı çocuklarda havayolu enflamasyonunun bir rolü olup olmadığının ve RSV enfeksiyonuyla ilişkisini belirlemekti. Bulgular: Hışıltılı 22K, 18E ve sağlıklı 18K, 20 E süt çocuklarında serum LIF, total IgE düzeyleri, RSV-IgM ve RSVIgG antikorları değerlendirilmiştir. Hışıltılı sütçocuklarının %25 ve sağlıklı çocukların %3’ünde RSV-IgM antikorları saptanmıştır. Çocukların sırasıyla %35 ve %25’inde RSV-IgG antikorları saptanmıştır. Hışıltılı ve sağlıklı süt çocukları arasında ortanca serum LIF düzeyleri arasında anlamlı bir farklılık yoktu. Ancak, RSV-IgM antikorları için seropozitif olan kişilerde ortanca serum LIF düzeyi RSV-IgM antikorlarına karşı seropozitif olan kişilere göre anlamlı derecede daha yüksekti 16 pg/ml’e karşı 10.5 pg/ml; p=0.01 . Sonuç: Bu çalışma LİF’in hışıltılı RSV enfeksiyonu olan süt çocuklarında erken dönem havayolu enflamasyonunda bir rol oynayabildiğini düşündürtmektedir

Keywords

Lösemi inhibitör faktör, hışıltı, çocuk, respiratory sinsityal virüs

Serum Levels of Leukemia Inhibitory Factor LIF in Wheezy Infants and its Relation with Respiratory Syncytial Virus Infection §

Abstract

Objective: Leukemia inhibitory factor LIF is the most pleiotropic member of the interleukin-6 family of cytokines. It utilises a receptor that consists of the LIF receptor β and gp130 and this receptor complex is also used by ciliary neurotrophic growth factor CNTF , oncostatin M, cardiotrophin1 CT1 and cardiotrophin-like cytokine CLC . Evidence is emerging that LIF may play an important role in airway inflammation. Recurrent wheezing is one of the commonest problems of early childhood and respiratory syncytial virus RSV is the most frequent cause of wheezy episodes. Material and Method: The aim of this study was to determine whether LIF has a role in the airway inflammation of wheezy children and its relationship with RSV infection. Results: Serum LIF levels, total IgE levels, RSV-IgM and RSVIgG antibodies were evaluated in wheezy 22F, 18M and healthy 18F, 20M infants. RSV-IgM antibodies were detected in 25% of wheezy and 3% of healthy children. RSV-IgG antibodies were detected 35% and 23%, respectively. There was not significant difference in median serum levels of LIF between wheezy and healthy infants. However, median serum LIF level of subjects who were seropositive for RSV-IgM antibodies was significantly higher than those who were seronegative for RSV-IgM antibodies 16 pg/ml vs 10.5 pg/ml; p=0.01 . Conclusion: This study suggests that LIF might play a role in early airway inflammation in infants with wheezy RSV infection

Keywords

Leukemia inhibitory factor, wheezy, children, respiratory syncytial virus

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