Nefrotik Sendromlu Çocuklarda Tedavi Yan Etkilerinin Değerlendirilmesi

Abstract

Amaç: Ülkemizde nefrotik sendrom NS tedavisi sırasında görülen yan etkilerin sıklığını yansıtan veriler yetersizdir. Bu çalışmada, kliniğimizde NS nedeniyle izlenen hastalarda ortaya çıkan tedavi yan etkilerinin değerlendirilmesi amaçlandı.Gereç ve Yöntem: İstanbul Üniversitesi İstanbul Tıp Fakültesi Çocuk Nefrolojisi Bilim Dalı Polikliniğine 1986-2010 yılları arasında başvuran ve NS tanısı ile izleme alınan toplam 206 hastanın 126 erkek, 80 kız poliklinik dosyaları incelenerek verileri geriye dönük olarak değerlendirildi.Bulgular: Çalışma grubuna alınan toplam 206 hastanın 126 erkek; 80 kız başvuru sırasındaki yaş ortalaması 3,8±2,8 yıl 0.2-13.8 yıl idi. İzlemde herhangi bir ilaca karşı hastaların 171’inde %83 en az bir yan etki oluştu. Steroid tedavisinde görülen yan etkiler sırasıyla cushingoid görünüm gelişmesi %52 , hipertansiyon %23.4 , büyüme geriliği %17 , katarakt %6.8 ve osteoporoz %6.8 idi. Büyüme geriliği, osteoporoz, katarakt ve hipertansiyon saptanan hastalarda saptanmayan hastalara göre steroid tedavi süresi ve toplam steroid dozu anlamlı olarak yüksekti p

Keywords

• Nefrotik sendrom,steroid tedavisi,steroide bağlı yan etkiler

Evaluation of the Advers Effects of the Treatment of Nephrotic Syndrome in Children

Abstract

Objective: The data reflecting adverse effects seen during the treatment of nephrotic syndrome NS in Turkey are limited. In this study, we aimed to evaluate the side effects of treatment of NS patients observed at our clinic.Material and Method: We retrospectively reviewed the data of 206 patients with NS 126 male; 80 female followed up at the Pediatric Nephrology outpatient clinic of the Istanbul University Istanbul Medical Faculty between 1986-2010.Results: Mean age of 206 126 male, 80 female patients at the time of admission was 3.8±2.8 years range: 0.2-13.8 . During follow-up, 171 patients 83% experienced at least one side effect due to any of the drugs. The most frequent side effects of steroid treatment in order of decreasing frequency were cushingoid appearance 52% , hypertension 23.4% , growth retardation 17% , cataract 6.8% and osteoporosis 6.8% . Total duration of steroid use and steriod dose were higher in the patients who suffered from growth retardation, osteoporosis, cataract, hypertension than in those who did not suffer these side effects p

Keywords

• Nephrotic syndrome,steroid therapy,steroidinduced side effect

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