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Çocuklarda Trombositopeniye Yaklaşım

Year 2016, , 67 - 73, 01.07.2016

Selime Aydoğdu Serap Karaman Zeynep Karakaş

https://doi.org/10.5222/j.child.2016.067

Abstract

Trombositler primer hemostazda görevli ana elemanlardır. Trombosit sayısının 150.000/mm3’den düşük olmasına trombositopeni denir. Trombositopenik hastaya yaklaşımda detaylı öykü alınması, tam fizik muayene yapılması ve labo- ratuar değerlendirmede periferik yaymanın kesinlikle ince- lenmsi gerekir. Trombositlerin sayı ve morfolojisi, küme oluşturması, diğer kan elemanlarının sayısal ve morfolojik değerlendirlmesi için periferik yayma tanısal yaklaşımda altın standarttır

Keywords

Çocuk trombositopeni periferik yayma

References

  • Beyan C, nevruz o. Kanama ve tromboz (Çeviri). Harrison İç Hastalıkları Prensipleri (Çeviri). Çeviri Editörü: Yahya Sağlıker. Cilt 1, 15. Edisyon, Nobel Tıp Kitabevleri, 2004: 354-60.
  • McGuinn C, Bussel JB. Disorders of platelets. Lanzkowsky’s manual of pediatric hematology and oncology. Sixth Edition 2016;239-278.
  • https://doi.org/10.1016/B978-0-12-801368-7.00014-4
  • Kılınç Y. Trombositopenilerde tanısal yaklaşım (Algoritma). Türk Pediatrik Hematoloji Derneği, TPHD Eğitim Serisi-IV, Trombosit Hastalıkları. Galenos Yayıncılık, 2017;31-34.
  • Liu Y, Chen S, Sun Y, Lin Q, Liao X, Zhang J, et al. Clinical characteristics of immune thrombocytopenia associated with autoimmune disease: A retrospective study. Medicine (Baltimore) 2016;95:5565.
  • https://doi.org/10.1097/MD.0000000000005565
  • Choi SI, mcClure Pd. Idiopathic thrombocytopenic purpura in childhood. Can Med Assoc J 1967;97:562- 568.
  • Franchini m. The platelet-function analyzer (PFA– 100®) for evaluating primary hemostasis. Hematology 2005;10:177-81.
  • https://doi.org/10.1080/10245330400026097
  • drachman JG. Inherited thrombocytopenia: when a low platelet count does not mean ITP. Blood 2004;103:390-8.
  • https://doi.org/10.1182/blood-2003-05-1742
  • Wilon DB. Acquired platelet disorders. In Nathan and Oski’s Hematology of infancy and childhood. 7th edition. 2009;1553-1590 .
  • Albert mH, noterangelo Ld, occhs Hd. Clinical spectrum, pathophysiology and treatment of theWiskott- Aldrich syndrome. Curr Opin Hematol 2011;18:42-8.
  • https://doi.org/10.1097/MOH.0b013e32834114bc
  • Evans rS, Takahashi K, duane rT. Primary throm- bocytopenic purpura and acquired haemolytic anemia. Arch Int Med 1951;87:48-65.
  • https://doi.org/10.1001/archinte.1951.03810010058005
  • Aul C, Giagounidis A, et al. Evaluating the prognosis of patients with myelodysplastic syndromes. Review article. Ann Hematol 2002;81:485-97.
  • https://doi.org/10.1007/s00277-002-0530-z
  • nakao S, Ishiyama K. Hypomegakaryocytic throm- bocytopenia and increased number of PNH-phenotype cells-an emerging subgroup of myelodysplastic syndro- me showing frequent response to immunosuppression- Response to Refferr to Rafferty&Leach. Correspon- dence. Br J Haematol 2017; 14755.
  • https://doi.org/10.1111/bjh.14755
  • Bussel JB. Alloimmune thrombocytopenia in the fetus and newborn. Semin Thromb Hemos 2001;27:245-52.
  • https://doi.org/10.1055/s-2001-15254
  • roberts I, Stanworth S, murray nA. Thrombocyto- phenia in neonate. Blood Rev 2008;22:173-86.
  • https://doi.org/10.1016/j.blre.2008.03.004
  • WongW, Glader B. Approach to the newborn who has thrombocytophenia. Neo Reviews 2004;5:444-9.
  • https://doi.org/10.1542/neo.5-10-e444
  • murray nA, Howarth LJ, mcCloy mP, Letsky EA, roberts IA. Platelet transfusion in the management of severe thrombocytophenia in neonatal intensive care unit patients. Transfus Med 2002;12:35-41.
  • https://doi.org/10.1046/j.1365-3148.2002.00343.x
  • Bussel JB, Zacharoulis S, Kramer K, mcFarland JG, Pauliny J, Kaplan C. Clinical and diagnostic comparison of neonatal alloımmune thrombocytophe- nia to non-immun cases of thromboctrophenia. Pediatr Blood Cancer 2005;45:176-83.
  • https://doi.org/10.1002/pbc.20282
  • George r. Buchanan. Thrombocytopenia during child- hood: What the pediatrician needs to know? Pediatrics in Review 2005;26(11):401-9.
  • Audia S, rossato m, Santegoets K, Spijkers S, Wichers C, Bekker C, et al. Splenic TFH expansion partipipates in B-cell differentiation and antiplatelet antibody production during immune thrombocytophe- nia. Blood 2014;124:2858-86.
  • https://doi.org/10.1182/blood-2014-03-563445
  • Cox K, Price V, Kahr WH. Inherited platelet disor- ders: a clinical approach to diagnosis and management. Expert Rev Hematol 2011;4:455-72.
  • Stasi r. How to approach thrombocytophenia. ASH Education Program Book 2012;191-197.

Approach to Thrombocytophenia in Children

Year 2016, , 67 - 73, 01.07.2016

Selime Aydoğdu Serap Karaman Zeynep Karakaş

https://doi.org/10.5222/j.child.2016.067

Abstract

Platelets are the key elements that are responsible for pri- mary hemostasis. When absolute number of platelets in peripheral blood is less than 150000/mm3, it is called thrombocytopenia. Detailed anamnesis, complete physical examination and a laboratory evaluation including perip- heral blood smear are vital when approaching to throm- bocytopenic patients. Peripheral blood smear is the gold standard diagnostic approach for quantitative, and morp- hological evaluation of number, morphology and clustering of platelets and other blood elements as well

Keywords

Child thrombocytophenia peripheral blood smear

References

  • Beyan C, nevruz o. Kanama ve tromboz (Çeviri). Harrison İç Hastalıkları Prensipleri (Çeviri). Çeviri Editörü: Yahya Sağlıker. Cilt 1, 15. Edisyon, Nobel Tıp Kitabevleri, 2004: 354-60.
  • McGuinn C, Bussel JB. Disorders of platelets. Lanzkowsky’s manual of pediatric hematology and oncology. Sixth Edition 2016;239-278.
  • https://doi.org/10.1016/B978-0-12-801368-7.00014-4
  • Kılınç Y. Trombositopenilerde tanısal yaklaşım (Algoritma). Türk Pediatrik Hematoloji Derneği, TPHD Eğitim Serisi-IV, Trombosit Hastalıkları. Galenos Yayıncılık, 2017;31-34.
  • Liu Y, Chen S, Sun Y, Lin Q, Liao X, Zhang J, et al. Clinical characteristics of immune thrombocytopenia associated with autoimmune disease: A retrospective study. Medicine (Baltimore) 2016;95:5565.
  • https://doi.org/10.1097/MD.0000000000005565
  • Choi SI, mcClure Pd. Idiopathic thrombocytopenic purpura in childhood. Can Med Assoc J 1967;97:562- 568.
  • Franchini m. The platelet-function analyzer (PFA– 100®) for evaluating primary hemostasis. Hematology 2005;10:177-81.
  • https://doi.org/10.1080/10245330400026097
  • drachman JG. Inherited thrombocytopenia: when a low platelet count does not mean ITP. Blood 2004;103:390-8.
  • https://doi.org/10.1182/blood-2003-05-1742
  • Wilon DB. Acquired platelet disorders. In Nathan and Oski’s Hematology of infancy and childhood. 7th edition. 2009;1553-1590 .
  • Albert mH, noterangelo Ld, occhs Hd. Clinical spectrum, pathophysiology and treatment of theWiskott- Aldrich syndrome. Curr Opin Hematol 2011;18:42-8.
  • https://doi.org/10.1097/MOH.0b013e32834114bc
  • Evans rS, Takahashi K, duane rT. Primary throm- bocytopenic purpura and acquired haemolytic anemia. Arch Int Med 1951;87:48-65.
  • https://doi.org/10.1001/archinte.1951.03810010058005
  • Aul C, Giagounidis A, et al. Evaluating the prognosis of patients with myelodysplastic syndromes. Review article. Ann Hematol 2002;81:485-97.
  • https://doi.org/10.1007/s00277-002-0530-z
  • nakao S, Ishiyama K. Hypomegakaryocytic throm- bocytopenia and increased number of PNH-phenotype cells-an emerging subgroup of myelodysplastic syndro- me showing frequent response to immunosuppression- Response to Refferr to Rafferty&Leach. Correspon- dence. Br J Haematol 2017; 14755.
  • https://doi.org/10.1111/bjh.14755
  • Bussel JB. Alloimmune thrombocytopenia in the fetus and newborn. Semin Thromb Hemos 2001;27:245-52.
  • https://doi.org/10.1055/s-2001-15254
  • roberts I, Stanworth S, murray nA. Thrombocyto- phenia in neonate. Blood Rev 2008;22:173-86.
  • https://doi.org/10.1016/j.blre.2008.03.004
  • WongW, Glader B. Approach to the newborn who has thrombocytophenia. Neo Reviews 2004;5:444-9.
  • https://doi.org/10.1542/neo.5-10-e444
  • murray nA, Howarth LJ, mcCloy mP, Letsky EA, roberts IA. Platelet transfusion in the management of severe thrombocytophenia in neonatal intensive care unit patients. Transfus Med 2002;12:35-41.
  • https://doi.org/10.1046/j.1365-3148.2002.00343.x
  • Bussel JB, Zacharoulis S, Kramer K, mcFarland JG, Pauliny J, Kaplan C. Clinical and diagnostic comparison of neonatal alloımmune thrombocytophe- nia to non-immun cases of thromboctrophenia. Pediatr Blood Cancer 2005;45:176-83.
  • https://doi.org/10.1002/pbc.20282
  • George r. Buchanan. Thrombocytopenia during child- hood: What the pediatrician needs to know? Pediatrics in Review 2005;26(11):401-9.
  • Audia S, rossato m, Santegoets K, Spijkers S, Wichers C, Bekker C, et al. Splenic TFH expansion partipipates in B-cell differentiation and antiplatelet antibody production during immune thrombocytophe- nia. Blood 2014;124:2858-86.
  • https://doi.org/10.1182/blood-2014-03-563445
  • Cox K, Price V, Kahr WH. Inherited platelet disor- ders: a clinical approach to diagnosis and management. Expert Rev Hematol 2011;4:455-72.
  • Stasi r. How to approach thrombocytophenia. ASH Education Program Book 2012;191-197.
There are 35 citations in total.

Details

Primary Language Turkish
Journal Section Research Articles
Authors

Selime Aydoğdu This is me

Serap Karaman This is me

Zeynep Karakaş This is me

Publication Date July 1, 2016
Published in Issue Year 2016

Cite

APA Aydoğdu, S., Karaman, S., & Karakaş, Z. (2016). Çocuklarda Trombositopeniye Yaklaşım. Çocuk Dergisi, 16(2), 67-73. https://doi.org/10.5222/j.child.2016.067
AMA Aydoğdu S, Karaman S, Karakaş Z. Çocuklarda Trombositopeniye Yaklaşım. Çocuk Dergisi. July 2016;16(2):67-73. doi:10.5222/j.child.2016.067
Chicago Aydoğdu, Selime, Serap Karaman, and Zeynep Karakaş. “Çocuklarda Trombositopeniye Yaklaşım”. Çocuk Dergisi 16, no. 2 (July 2016): 67-73. https://doi.org/10.5222/j.child.2016.067.
EndNote Aydoğdu S, Karaman S, Karakaş Z (July 1, 2016) Çocuklarda Trombositopeniye Yaklaşım. Çocuk Dergisi 16 2 67–73.
IEEE S. Aydoğdu, S. Karaman, and Z. Karakaş, “Çocuklarda Trombositopeniye Yaklaşım”, Çocuk Dergisi, vol. 16, no. 2, pp. 67–73, 2016, doi: 10.5222/j.child.2016.067.
ISNAD Aydoğdu, Selime et al. “Çocuklarda Trombositopeniye Yaklaşım”. Çocuk Dergisi 16/2 (July 2016), 67-73. https://doi.org/10.5222/j.child.2016.067.
JAMA Aydoğdu S, Karaman S, Karakaş Z. Çocuklarda Trombositopeniye Yaklaşım. Çocuk Dergisi. 2016;16:67–73.
MLA Aydoğdu, Selime et al. “Çocuklarda Trombositopeniye Yaklaşım”. Çocuk Dergisi, vol. 16, no. 2, 2016, pp. 67-73, doi:10.5222/j.child.2016.067.
Vancouver Aydoğdu S, Karaman S, Karakaş Z. Çocuklarda Trombositopeniye Yaklaşım. Çocuk Dergisi. 2016;16(2):67-73.