Akut Gastroenteritli Çocuklarda Norovirüs, Rotavirüs ve Adenovirüs Sıklığı

Abstract

Amaç: Acil çocuk polikliniğine başvuran akut ishalli çocuklarda rotavirüs, nörovirüs ve adenovirüs sıklığı araştırıldı.Gereç ve Yöntem: Ekim 2012-Ocak 2013 döneminde, Çocuk Acil Polikliniğine ishalle başvuran, 164 hastadan dışkı örneği alınabilen 126 hasta çalışma grubunu oluşturdu. ELISA yöntemiyle üç virüs tipinin belirlenmesi çalışıldı. Hastaların ishal sayısı ve süresi, kusma sayısı ve süresi ateş düzeyi, ishal etkenlerinin düzeyi ve yaş ile klinik ağırlık arasındaki ilişki değerlendirildi.Bulgular: Hastaların 23’ünde %18,2 rotavirüs, 13’ünde %10,3 adenovirüs, 11’inde %8,7 ise norovirüs pozitif saptandı. Üç ishal etkeninin de en çok görüldüğü yaş dilimi 1-5’ti. Norovirüs daha küçük yaş grubunda tespit edildi. Rotavirüs enfeksiyonu ocak ayında en fazla görülürken adenovirüs ve norovirüs hem aralık hem de ocak ayında saptandı. Üç ishal etkeninin de klinik ağırlık skorlamasında istatistiksel olarak anlamlı farklılık saptanmadı. Buna karşın adenovirüsün klinik skorlaması daha yüksekti.Sonuç: Ülkemizde rotavirüs, adenovirüs antijen taramaları kolaylıkla yapılırken norovirüs için hızlı güvenilir tanı tekniklerinin yaygınlaşması gerekmektedir. Rotavirüs aşısının uygulanabilirliğini artırmaya ve aşısının etkinliğine yönelik çalışmalar yapılmalıdır

Keywords

• Akut viral gastroenterit,norovirüs,rotavirüs ve adenovirüs

The Incidence of Norovirus, Rotavirus and Adenovirus in Children with Acute Gastroenteritis

Abstract

Objective: To investigate the incidence of norovirus, rotavirus and adenovirus in children who presented to the pediatric emergency service with acute diarrhea.Material and Method: One hundred and twenty-six children among 164 patients who presented to our pediatric emergency department with diarrhea, and gave stool samples between October 2012 and February 2013 were enrolled in the study. Stool samples were analysed for norovirus, rotavirus and adenovirus. The association among frequency, duration of diarrhea, and vomiting, body temperature, age, causative factors of diarrhea, and clinical severity of the disease was evaluated.Results: Rotavirus, adenovirus, and norovirus were identified in 18.2% n=23 , 103 n=13 , and 8.7 % n=11 of the patients, respectively. These three causative agent of diarrhea were most frequently seen in children between 1-5 years of age. Norovirus was more frequent in younger children. Rotavirus infection was more common in January, whereas adenovirus and norovirus were detected in December and January. Any statistically significant difference was not found among three agents of diarrhea in terms of disease severity. However, patients with adenovirus related diarrhea had a higher clinical disease severity score. Conclusion: In our country rotavirus, adenovirus antijen screening tests are easily performed, however rapid and reliable diagnostic tests for norovirus should be used prevalently. Studies aiming at applicability, and effectiveness of rotavirus vaccination should be conducted

Keywords

• Acute viral gastroenteritis,norovirus,rotavirus and adenovirus

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