Yaşamı Tehdit Eden Sistemik Lupus Eritematozus Vakasında Rituksimab Tedavisi

Abstract

Sistemik Lupus Eritematozus, heterojen otoinflamatuar bir hastalıktır. Patofizyolojisinde genetik nedenlerin yanında çevresel multifaktöryel etkenler suçlanmıştır. B hücrelerinin aşırı aktivasyonunun lupus patofizyolojisin- de önemli rol oynadığı gösterilmiştir. Çocuklarda tedavi- sinde steroidler ve immunsupresif ajanlar kullanılmakta- dır. Rituksimab, B lenfositlerin CD20 antijenlerine karşı geliştirilen bir biyolojik ajandır. B hücrelerine bağlı oto- inflamatuvar hastalıklarda etkin olduğu gösterilmiştir. Bu makalede, ciddi komplikasyonları olan ve diğer immun- supresif tedavilere yanıt vermeyen sistemik lupus eritema- tozus tanılı çocuk vakasında rituksimab tedavisi deneyimi paylaşılacaktır

Keywords

• Sistemik Lupus Eritematozus,rituksimab,immunsupresif ajanlar

Rituximab Treatment of A Case with Life-Threatening Systemic Lupus Erythematosus

Abstract

Systemic Lupus Erythematosus SLE is a heterogeneous autoinflammatory disease. Genetic and environmental multi- factorial agents have been implicated in its pathophysiology. Hyperactivation of B cells has been demonstrated to play a central role in SLE pathophysiology. Steroids and immuno- suppressive agents are administered in the treatment of child- ren. Rituximab is a biologic agent developed against CD20 antigens of B cells. It has been shown that rituximab is effec- tive in B cell-dependent autoinflammatory diseases. In this paper, we will share our experience about rituximab treatment of a pediatric case with the diagnosis of lupus erythematosus with severe complications and unresponsive to other immuno- suppressive therapies

Keywords

• Systemic Lupus Erythematosus SLE,rituximab,immunosuppressive agents

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