A Rare Case Report of Amlodipine-Induced Gingival Hyperplasia
Year 2020,
Volume: 20 Issue: 1, 33 - 35, 10.07.2020
Ayşe Pınar Göksu Çetinkaya
Leyla Asgarova
Abstract
Calcium channel blockers are the most commonly used drugs in the treatment of hypertension in childhood. Gingival hyperplasia is one of the rare side effects of calcium channel blocker use. Among calcium channel blockers, it is most commonly seen due to nephidipine. Gingival hyperplasia is less frequently observed with the use of amlodipine. In our case, gingival hyperplasia developed as a rare side effect during low dose amlodipine treatment. This case has been reported to emphasize that the development of gingival hyperplasia in patients with hypertension may be a side effect of amlodipine use.
References
- 1. Tungare S, Paranjpe AG. Drug Induced Gingival Overgrowth. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020.
https://www.ncbi.nlm.nih.gov/books/NBK538518/
- 2. Amlodipine. Drug information. https://www.uptodate.com/contents/ amlodipine-drug-information.
- 3. Ellis JS, Seymour RA, Thomason JM, Monkman SC, Idle JR. Gingival sequestration of amlodipine induced gingival overgrowth. Lancet 1993;341:1102-3.
- 4. Jorgensen MG. Prevalence of amlodipine-related gingival hyperplasia. J Periodontol 1997;68(7):676-8.
- 5. Ellis JS, Seymour RA, Steele JG, Robertson P, Butler TJ, Thomason JM. Prevalence of gingival overgrowth induced by calcium channel blockers: a community-based study. J Periodontol 1999;70(1):63-7.
- 6. Ono M, Tanaka S, Takeuchi R, Matsumoto H, Okada H, Yamamoto H, et al. Prevelance of amlodipine-induced gingival overgrowth. Int J Oral-Med Sci 2010;9(2):96-100.
- 7. Tripathi AK, Mukherjee S, Saimbi CS, Kumar V. Low dose amlodipine-induced gingival enlargement: A clinical case series. Contemp Clin Dent 2015;6(1):107-9.
- 8. Keels MA. Soft tissue lesions of the oral cavity in children. 2019 Jun: https://www.uptodate.com/contents/soft-tissue-lesions-ofthe-oral-cavity-in-children.
- 9. Lauritano D, Lucchese A, Stasio DD, Vella FD, Cura F, Palmieri A, et al. Molecular aspects of drug-induced gingival overgrowth: an in vitro study on amlodipine and gingival fibroblasts. Int J Mol Sci 2019;20(8):2047.
- 10. Gaur S, Agnihotri R. Is dental plaque the only etiological factor in amlodipine induced gingival overgrowth? A systematic review of evidence. J Clin Exp Dent 2018;10(6):610-9.
Nadir Bir Yan Etki Olarak Amlodipine Bağlı Dişeti Hiperplazisi
Year 2020,
Volume: 20 Issue: 1, 33 - 35, 10.07.2020
Ayşe Pınar Göksu Çetinkaya
Leyla Asgarova
Abstract
Çocukluk çağında hipertansiyon tedavisinde kalsiyum kanal blokerleri en sık kullanılan ilaçlardandır. Dişeti hiperplazisi kalsiyum kanal blokeri kullanımının nadir yan etkilerindendir. Kalsiyum kanal blokerlerinden en sık nefidipine bağlı olarak görülmektedir. Daha az sıklıkla amlodipin kullanımıyla gözlenmektedir. Vakamızda düşük doz amlodipin tedavisi sırasında nadir bir yan etki olarak dişeti hiperplazisi gelişmişti. Bu olgu hipertansiyon nedeniyle tedavi alan hastalarda dişeti hiperplazisi gelişiminin amlodipin kullanımının yan etkisi sonucunda oluşabileceğini vurgulamak amacıyla bildirilmiştir.
References
- 1. Tungare S, Paranjpe AG. Drug Induced Gingival Overgrowth. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020.
https://www.ncbi.nlm.nih.gov/books/NBK538518/
- 2. Amlodipine. Drug information. https://www.uptodate.com/contents/ amlodipine-drug-information.
- 3. Ellis JS, Seymour RA, Thomason JM, Monkman SC, Idle JR. Gingival sequestration of amlodipine induced gingival overgrowth. Lancet 1993;341:1102-3.
- 4. Jorgensen MG. Prevalence of amlodipine-related gingival hyperplasia. J Periodontol 1997;68(7):676-8.
- 5. Ellis JS, Seymour RA, Steele JG, Robertson P, Butler TJ, Thomason JM. Prevalence of gingival overgrowth induced by calcium channel blockers: a community-based study. J Periodontol 1999;70(1):63-7.
- 6. Ono M, Tanaka S, Takeuchi R, Matsumoto H, Okada H, Yamamoto H, et al. Prevelance of amlodipine-induced gingival overgrowth. Int J Oral-Med Sci 2010;9(2):96-100.
- 7. Tripathi AK, Mukherjee S, Saimbi CS, Kumar V. Low dose amlodipine-induced gingival enlargement: A clinical case series. Contemp Clin Dent 2015;6(1):107-9.
- 8. Keels MA. Soft tissue lesions of the oral cavity in children. 2019 Jun: https://www.uptodate.com/contents/soft-tissue-lesions-ofthe-oral-cavity-in-children.
- 9. Lauritano D, Lucchese A, Stasio DD, Vella FD, Cura F, Palmieri A, et al. Molecular aspects of drug-induced gingival overgrowth: an in vitro study on amlodipine and gingival fibroblasts. Int J Mol Sci 2019;20(8):2047.
- 10. Gaur S, Agnihotri R. Is dental plaque the only etiological factor in amlodipine induced gingival overgrowth? A systematic review of evidence. J Clin Exp Dent 2018;10(6):610-9.