Meningokok Aşıları

Year 2019, Volume: 19 Issue: 2, 51 - 59, 01.07.2019

Manolya Kara Ayper Somer

https://doi.org/10.5222/j.child.2019.40427

Abstract

Neisseria meningitidis, asemptomatik taşıyıcılıktan yaşamı tehdit eden invazif meningokok hastalığına kadar geniş bir yelpazede karşımıza çıkmaktadır. Hastalığa karşı,dünyada yaygın olarak kullanımda olan iki çeşit polisakkarit ve konjüge meningokok aşısı mevcuttur. Polisakkarit meningokok aşıları 2 yaşından sonra, özellikle invazif meningokok hastalık riskinin arttığı adolesan ve genç erişkinlerde, konjüge aşıların bulunmadığı ülkelerde tercih edilmektedir. Konjüge meningokok aşılarından MenACWYCRM, 2 aylıktan itibaren kullanılabilmesi nedeniyle önem taşımaktadır. Yapılan çalışmalar sonucu MenACWY-CRM aşısı sütçocuğu, çocuk, adolesan ve erişkinlerde etkin ve düşük yan etki profiline sahip bulunmuştur

Keywords

İnvaziv meningokok hastalığı, meningokok aşıları, MenACWY-CRM aşısı

Meningococcal Vaccines

Abstract

Neisseria meningitidis confronts us in a wide spectrum of diseases ranging from asymptomatic carriership to life-threatening invasive meningococcal disease. Worldwide, two types of meningococcal vaccines polysaccharide and conjugated are in clinical use against the disease. Polysaccharide meningococcal vaccines are preferred in countries where there is no access of conjugate vaccine in adolescents and young adults after the age of 2, who are particularly at risk for invasive meningococcal disease. As one of the conjugated meningococcal vaccines MenACWY-CRM is important since it can be used from 2 months of age. The results of the studies have shown that the MenACWY-CRM vaccine is effective and has a low side-effect profile in infants, children, adolescents and adults.

Keywords

Invasive meningococcal disease, meningococcal vaccines, MenACWY-CRM vaccine

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