Akut Lenfoblastik Löseminin Ender İlk Başvuru Bulgusu: Bilateral Nefromegali

Enes Çelik; Nurdan Yıldız; Serçin Güven; Emel Şenay; İbrahim Gökçe

doi:10.5222/j.child.2017.036

Akut Lenfoblastik Löseminin Ender İlk Başvuru Bulgusu: Bilateral Nefromegali

Year 2017, Volume: 17 Issue: 1, 36 - 38, 01.01.2017

Enes Çelik Nurdan Yıldız Serçin Güven Emel Şenay İbrahim Gökçe

https://doi.org/10.5222/j.child.2017.036

Abstract

Akut lenfoblastik lösemi ALL çocukluk çağının en sık görülen kanseridir. Hastaların %8-16’sında klinik bulgu vermeyen böbrek tutulumu görülebilir, bunların çoğunda hasta lösemi tanısı aldıktan sonra böbrek tutulumu sapta- nır. Bu makalede karında şişkinlik nedeniyle başvuran, bilateral nefromegalisi olan ve tetkiklerin sonucunda pre B hücreli ALL tanısı alan 18 aylık vaka sunularak nefromega- linin ayırıcı tanısında lösemik infiltrasyonun önemi vurgu- landı

Keywords

Nefromegali, akut lenfoblastik lösemi, böbrek tutulumu, lösemik infiltrasyon

References

Erdem E, kayıran p, ozcelik G, ozel A, Yildiz Yildirmak z. Rare presentation of pediatric acute lymphoblastic leuke- mia: nephromegaly at time of diagnosis. Indian J Hematol Blood Transfus 2011;27:43-5. https://doi.org/10.1007/s12288-010-0052-0
Lanzkowsky p. Manual of Pediatric Hematology and Oncology. 5th ed. New York: Elsevier, 2011; 518-66. https://doi.org/10.1016/B978-0-12-375154-6.00017-3
olgar S, Cetin M, Gürgey A, Tuncer M, Gümrük F, oner AF, et al. Akut lenfoblastik lösemili hastalarda hücre morfo- lojisi ve böbrek etkilenmesi. 29. Ulusal Hematoloji Kongresi 25-28 Kasım, Kemer/Antalya, 2002;19:1.
Hann ıM, Lees pd, palmer Mk, Gupta S, Morris-Jones pH. Renal size as a prognostic factor in childhood acute lymphoblastic leukemia. Cancer 1981;48:207-9. https://doi.org/10.1002/1097-0142(19810701)48: 13.0.CO;2-0
doğan M, Bay A, Bora A, Açıkgöz M, öner AF. Massively enlarged kidneys due to leukemic infiltration in a child. European Journal of General Medicine 2010; 114-7.
pradeep R, Madhumathi dS, Lakshmidevi v, premalata CS, Appaji L, patil SA, Swapnil B. Bilateral nephromegaly simula- ting wilms tumor: a rare initial manifestation of acute lymphob- lastic leukemia. J Pediatr Hematol Oncol 2008;30:471-3. https://doi.org/10.1097/MPH.0b013e318168e7b3
Saha A, dandekar S, Milla S, Roman E, Bhatla T. Bilateral parotid gland enlargement and palpable nephromegaly in infant acute lymphoblastic leukemia: case report and review of the literature. J Pediatr Hematol Oncol 2014;36:246-8. https://doi.org/10.1097/MPH.0000000000000076
Aksu Uzunhan T, karakaş z. Çocukluk çağı akut Lenfoblastik Lösemisi. Çocuk Dergisi 2012;12:6-15. https://doi.org/10.5222/j.child.2012.006
Boueva A, Bouvier R. Precursor B-cell lymphoblastic leuke- mia as a cause of a bilateral nephromegaly. Pediatr Nephrol 2005;20:679-82. https://doi.org/10.1007/s00467-004-1740-5
Hilmes MA, dillman JR, Mody RJ, Strouse pJ. Pediatric renal leukemia: spectrum of CT imaging findings. Pediatr Radiol 2008;38:424-30. https://doi.org/10.1007/s00247-007-0741-5
Aguayo p, Fraser Jd, St peter Sd, Spilde T, Gatti JM, Snyder CL, ostlie dJ. Massive bilateral nephromegaly in acute lymphoblastic leukemia: a case report. Eur J Pediatr Surg 2009;19:332-4. https://doi.org/10.1055/s-2008-1039191
Araki T. Leukemic Involvement of the Kidney in Children: CT Features. J Comput Assist Tomogr 1982;6:781-4. https://doi.org/10.1097/00004728-198208000-00022
Spiegel A, kollet o, peled A, Abel L, Nagler A, Bielorai B, et al. Unique SDF-1-induced activation of human precursor-B ALL cells as a result of altered CXCR4 expression and signa- ling. Blood 2004;103: 2900-7. https://doi.org/10.1182/blood-2003-06-1891
Stefanidakis M, karjalainen k, Jaalouk dE, Gahmberg CG, o’Brien S, pasqualini R, et al. Role of leukemia cell inva- dosome in extramedullary infiltration. Blood 2009;114:3008-17. https://doi.org/10.1182/blood-2008-04-148643

An Unusual Cause of Bilateral Nephromegaly as the Rarely Seen First Presenting Finding of Acute Lymphoblastic Leukemia

Year 2017, Volume: 17 Issue: 1, 36 - 38, 01.01.2017

Enes Çelik Nurdan Yıldız Serçin Güven Emel Şenay İbrahim Gökçe

https://doi.org/10.5222/j.child.2017.036

Abstract

Acute lymphoblastic leukemia ALL is the most common type of cancer in childhood. Renal involvement may occur in 8-16% of patients without clinical manifestation and is detected in the majority of these cases renal involvement is detected after the patient received diagnosis of leukemia.. In this article, we presented a 18 month-old girl presented with abdominal distension and bilateral nephromegaly who was diagnosed with pre-B cell B-cell precursor acute lymphob- lastic leukemia, and emphasized that lymphoblastic infiltra- tion should be considered in the differential diagnosis of a patient presenting with unexplained nephromegaly

Keywords

Nephromegaly, acute lymphoblastic leukemia, renal involvement, lymphoblastic infiltration

References

Erdem E, kayıran p, ozcelik G, ozel A, Yildiz Yildirmak z. Rare presentation of pediatric acute lymphoblastic leuke- mia: nephromegaly at time of diagnosis. Indian J Hematol Blood Transfus 2011;27:43-5. https://doi.org/10.1007/s12288-010-0052-0
Lanzkowsky p. Manual of Pediatric Hematology and Oncology. 5th ed. New York: Elsevier, 2011; 518-66. https://doi.org/10.1016/B978-0-12-375154-6.00017-3
olgar S, Cetin M, Gürgey A, Tuncer M, Gümrük F, oner AF, et al. Akut lenfoblastik lösemili hastalarda hücre morfo- lojisi ve böbrek etkilenmesi. 29. Ulusal Hematoloji Kongresi 25-28 Kasım, Kemer/Antalya, 2002;19:1.
Hann ıM, Lees pd, palmer Mk, Gupta S, Morris-Jones pH. Renal size as a prognostic factor in childhood acute lymphoblastic leukemia. Cancer 1981;48:207-9. https://doi.org/10.1002/1097-0142(19810701)48: 13.0.CO;2-0
doğan M, Bay A, Bora A, Açıkgöz M, öner AF. Massively enlarged kidneys due to leukemic infiltration in a child. European Journal of General Medicine 2010; 114-7.
pradeep R, Madhumathi dS, Lakshmidevi v, premalata CS, Appaji L, patil SA, Swapnil B. Bilateral nephromegaly simula- ting wilms tumor: a rare initial manifestation of acute lymphob- lastic leukemia. J Pediatr Hematol Oncol 2008;30:471-3. https://doi.org/10.1097/MPH.0b013e318168e7b3
Saha A, dandekar S, Milla S, Roman E, Bhatla T. Bilateral parotid gland enlargement and palpable nephromegaly in infant acute lymphoblastic leukemia: case report and review of the literature. J Pediatr Hematol Oncol 2014;36:246-8. https://doi.org/10.1097/MPH.0000000000000076
Aksu Uzunhan T, karakaş z. Çocukluk çağı akut Lenfoblastik Lösemisi. Çocuk Dergisi 2012;12:6-15. https://doi.org/10.5222/j.child.2012.006
Boueva A, Bouvier R. Precursor B-cell lymphoblastic leuke- mia as a cause of a bilateral nephromegaly. Pediatr Nephrol 2005;20:679-82. https://doi.org/10.1007/s00467-004-1740-5
Hilmes MA, dillman JR, Mody RJ, Strouse pJ. Pediatric renal leukemia: spectrum of CT imaging findings. Pediatr Radiol 2008;38:424-30. https://doi.org/10.1007/s00247-007-0741-5
Aguayo p, Fraser Jd, St peter Sd, Spilde T, Gatti JM, Snyder CL, ostlie dJ. Massive bilateral nephromegaly in acute lymphoblastic leukemia: a case report. Eur J Pediatr Surg 2009;19:332-4. https://doi.org/10.1055/s-2008-1039191
Araki T. Leukemic Involvement of the Kidney in Children: CT Features. J Comput Assist Tomogr 1982;6:781-4. https://doi.org/10.1097/00004728-198208000-00022
Spiegel A, kollet o, peled A, Abel L, Nagler A, Bielorai B, et al. Unique SDF-1-induced activation of human precursor-B ALL cells as a result of altered CXCR4 expression and signa- ling. Blood 2004;103: 2900-7. https://doi.org/10.1182/blood-2003-06-1891
Stefanidakis M, karjalainen k, Jaalouk dE, Gahmberg CG, o’Brien S, pasqualini R, et al. Role of leukemia cell inva- dosome in extramedullary infiltration. Blood 2009;114:3008-17. https://doi.org/10.1182/blood-2008-04-148643

There are 14 citations in total.

Details

Primary Language	Turkish
Journal Section	Research Articles
Authors	Enes Çelik This is me Nurdan Yıldız This is me Serçin Güven This is me Emel Şenay This is me İbrahim Gökçe This is me
Publication Date	January 1, 2017
Published in Issue	Year 2017 Volume: 17 Issue: 1

Cite

APA	Çelik, E., Yıldız, N., Güven, S., Şenay, E., et al. (2017). Akut Lenfoblastik Löseminin Ender İlk Başvuru Bulgusu: Bilateral Nefromegali. Journal of Child, 17(1), 36-38. https://doi.org/10.5222/j.child.2017.036
AMA	Çelik E, Yıldız N, Güven S, Şenay E, Gökçe İ. Akut Lenfoblastik Löseminin Ender İlk Başvuru Bulgusu: Bilateral Nefromegali. Journal of Child. January 2017;17(1):36-38. doi:10.5222/j.child.2017.036
Chicago	Çelik, Enes, Nurdan Yıldız, Serçin Güven, Emel Şenay, and İbrahim Gökçe. “Akut Lenfoblastik Löseminin Ender İlk Başvuru Bulgusu: Bilateral Nefromegali”. Journal of Child 17, no. 1 (January 2017): 36-38. https://doi.org/10.5222/j.child.2017.036.
EndNote	Çelik E, Yıldız N, Güven S, Şenay E, Gökçe İ (January 1, 2017) Akut Lenfoblastik Löseminin Ender İlk Başvuru Bulgusu: Bilateral Nefromegali. Journal of Child 17 1 36–38.
IEEE	E. Çelik, N. Yıldız, S. Güven, E. Şenay, and İ. Gökçe, “Akut Lenfoblastik Löseminin Ender İlk Başvuru Bulgusu: Bilateral Nefromegali”, Journal of Child, vol. 17, no. 1, pp. 36–38, 2017, doi: 10.5222/j.child.2017.036.
ISNAD	Çelik, Enes et al. “Akut Lenfoblastik Löseminin Ender İlk Başvuru Bulgusu: Bilateral Nefromegali”. Journal of Child 17/1 (January 2017), 36-38. https://doi.org/10.5222/j.child.2017.036.
JAMA	Çelik E, Yıldız N, Güven S, Şenay E, Gökçe İ. Akut Lenfoblastik Löseminin Ender İlk Başvuru Bulgusu: Bilateral Nefromegali. Journal of Child. 2017;17:36–38.
MLA	Çelik, Enes et al. “Akut Lenfoblastik Löseminin Ender İlk Başvuru Bulgusu: Bilateral Nefromegali”. Journal of Child, vol. 17, no. 1, 2017, pp. 36-38, doi:10.5222/j.child.2017.036.
Vancouver	Çelik E, Yıldız N, Güven S, Şenay E, Gökçe İ. Akut Lenfoblastik Löseminin Ender İlk Başvuru Bulgusu: Bilateral Nefromegali. Journal of Child. 2017;17(1):36-8.