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Nötropeniye Yaklaşım

Year 2015, Volume: 15 Issue: 1, 3 - 9, 01.01.2015

Selime Aydoğdu Ahsen Çelik Zeynep Karakaş

https://doi.org/10.5222/j.child.2015.003

Abstract

Mutlak nötrofil sayısının 15000/mm3’ün altına düşmesi olarak tanımlanan nötropeni çocukluk çağında sık rastla- nan ve etiyopatogenezinde birçok mekanizmanın rol aldı- ğı bir tablodur. Konjenital ve akkiz nedenlerle ortaya çıkabilir. Klinik yelpazesi oldukça geniştir. Çok ağır ölümcül olabilen enfeksiyonlarla seyredebildiği gibi, semptom vermeden yalnızca laboratuvar tanısı almış vakalar da mevcuttur. Nedene bağlı olarak değişen klinik bulgular nedeniyle klinisyenler tanı koyma ve tedavi yak- laşımında bazen güçlükler yaşayabilmektedir. Nötropenik bir hastada değerlendirme yaparken ateşin öncelikle var- lığı dikkate alınmalıdır. Ateş varsa ayırıcı tanı için değer- lendirme yapmadan hızlı bir şekilde hastanın tedavisine başlamak sonrasında, detaylı değerlendirmeleri yapmak uygun yaklaşımdır. Bu yazıda nötropenik hastanın tanısı ve tedavi yaklaşımları üzerine derleme yapılmıştır

Keywords

Nötropeni çocuk tanı tedavi

References

  • Bonilla MA. Disorders of white blood cells. Manual of Pediatric Hematology and Oncology, Lanzkowsky, 5th edition, Amsterdam, Elsevier, 2011, PPP:272-320.
  • Clay Me, Schuller rM, Bachowski GJ, et al. Granulocyte serology: current concepts and clinical significance. Immunohematology 2010;26:11-21.
  • Newburger Pe, dale dC. Evaluation and manage- ment of patients with isolated neutropenia. Semin Hematol 2013;50:198-206. http://dx.doi.org/10.1053/j.seminhematol.2013.06.010
  • Boxer lA. How to approach neutropenia. Hematology Am Soc Hematol Educ Program 2012;174-82.
  • dinauer MC Newburger Pe. Quantitative granulocyte and mononuclear phagocyte disorders. In Nathan and Oski’s Hematology of Infancy and Childhood, Orkin SH, Nathan DG, Ginsburg D, Look AT, Fisher DE, Lux SE eds, 7 thedition, Philedelphia, Saunders Elsevier, 2009;1137-1152.
  • dale dC, Bolyard AA, Schwinzer BG, et al. The severe chronic neutropenia international registry: 10-year follow-up report. Support Cancer Ther 2006; 3:220-31. http://dx.doi.org/10.3816/SCT.2006.n.020
  • Marton keszei, lisa S. Westerberg. Congenital defects in neutrophil dynamics. Department of microbiology Tumor and Cell Biology. Karoinska Instituted. Received 29 May 2014, Accepted 2 July 2014: Published 5 August 2014.
  • donadieu J, Beaupain B, Mahlaoui N, et al. Epidemiology of congenital neutropenia. Hematol Oncol Clin N Am 2013;27:1-17. http://dx.doi.org/10.1016/j.hoc.2012.11.003
  • Vandenberghe P, Beel C. Severe congenital neutrope- nia, a genetically heterogeneous disease group with an increased risk of AML/MDS. Pediatr Rep 2011;3(Suppl 2):e9. PMid:22053285 PMCid:3206537 http://dx.doi.org/10.4081/pr.2011.s2.e9
  • Husain eH, Mullah-Ali A, Al-Sharidah S, et al. Infectious etiologies of transient neutropenia in previo- usly healthy children. Pediatr Infect Dis J 2012; 31:575-7. http://dx.doi.org/10.1097/INF.0b013e318250084a
  • Andre’s e, et al. Current opinion in hematology 15.15.2008. http://dx.doi.org/10.1097/MOH.0b013e3282f15fb9
  • Bux J, Behre G, Jaeger G, et al. Diagnosis and clini- cal course of autoimmune neutropenia in infancy: analysis of 240 cases. Blood 1998;91:181-6.
  • Bruin M, dassen A, Pajkrt d, et al. Primary autoim- mune neutropenia in children: a study of neutrophil antibodies and clinical course. VoxSang 2005;88:52-9. http://dx.doi.org/10.1111/j.1423-0410.2005.00585.x
  • Berliner N, Horwitz M, loughran TP. Congenital and acquired neutropenia. Hematoogy Am Soc Educ Program 2004. pp:63-79. PMid:15561677
  • Janka Ge, lehmberg k. Hemophagocytic lymhohis- tiocytosis: pathogenesis and treatment. Hematology Am Soc Hematol Educ Program 2013;2013:605-11.

An Approach to Neutrophenia

Year 2015, Volume: 15 Issue: 1, 3 - 9, 01.01.2015

Selime Aydoğdu Ahsen Çelik Zeynep Karakaş

https://doi.org/10.5222/j.child.2015.003

Abstract

Neutropenia is defined as an absolute neutrophil count below 15000/mm3 . It is frequently encountered in pediatric age and many mechanisms can be involved in its etiopathogenesis. It can manifest as a congenital or an acquired entity. The clinical presentation can range from potentially fatal infections to asymptomatic laboratory findings. Because of varying symptoms dependent on etiologies, clinicians often have difficulty in diagnosis and management. The presence of fever priorly requires attention when evaluating neutropenia. When fever is present, commencing immediate treatment of the patient without making assessments for differential diagnosis and performing detailed evaluations is an appropriate approach This manuscript reviews the diagnostic, therapeutic approaches to neutropenia

Keywords

Neutrophenia child diagnosis treatment

References

  • Bonilla MA. Disorders of white blood cells. Manual of Pediatric Hematology and Oncology, Lanzkowsky, 5th edition, Amsterdam, Elsevier, 2011, PPP:272-320.
  • Clay Me, Schuller rM, Bachowski GJ, et al. Granulocyte serology: current concepts and clinical significance. Immunohematology 2010;26:11-21.
  • Newburger Pe, dale dC. Evaluation and manage- ment of patients with isolated neutropenia. Semin Hematol 2013;50:198-206. http://dx.doi.org/10.1053/j.seminhematol.2013.06.010
  • Boxer lA. How to approach neutropenia. Hematology Am Soc Hematol Educ Program 2012;174-82.
  • dinauer MC Newburger Pe. Quantitative granulocyte and mononuclear phagocyte disorders. In Nathan and Oski’s Hematology of Infancy and Childhood, Orkin SH, Nathan DG, Ginsburg D, Look AT, Fisher DE, Lux SE eds, 7 thedition, Philedelphia, Saunders Elsevier, 2009;1137-1152.
  • dale dC, Bolyard AA, Schwinzer BG, et al. The severe chronic neutropenia international registry: 10-year follow-up report. Support Cancer Ther 2006; 3:220-31. http://dx.doi.org/10.3816/SCT.2006.n.020
  • Marton keszei, lisa S. Westerberg. Congenital defects in neutrophil dynamics. Department of microbiology Tumor and Cell Biology. Karoinska Instituted. Received 29 May 2014, Accepted 2 July 2014: Published 5 August 2014.
  • donadieu J, Beaupain B, Mahlaoui N, et al. Epidemiology of congenital neutropenia. Hematol Oncol Clin N Am 2013;27:1-17. http://dx.doi.org/10.1016/j.hoc.2012.11.003
  • Vandenberghe P, Beel C. Severe congenital neutrope- nia, a genetically heterogeneous disease group with an increased risk of AML/MDS. Pediatr Rep 2011;3(Suppl 2):e9. PMid:22053285 PMCid:3206537 http://dx.doi.org/10.4081/pr.2011.s2.e9
  • Husain eH, Mullah-Ali A, Al-Sharidah S, et al. Infectious etiologies of transient neutropenia in previo- usly healthy children. Pediatr Infect Dis J 2012; 31:575-7. http://dx.doi.org/10.1097/INF.0b013e318250084a
  • Andre’s e, et al. Current opinion in hematology 15.15.2008. http://dx.doi.org/10.1097/MOH.0b013e3282f15fb9
  • Bux J, Behre G, Jaeger G, et al. Diagnosis and clini- cal course of autoimmune neutropenia in infancy: analysis of 240 cases. Blood 1998;91:181-6.
  • Bruin M, dassen A, Pajkrt d, et al. Primary autoim- mune neutropenia in children: a study of neutrophil antibodies and clinical course. VoxSang 2005;88:52-9. http://dx.doi.org/10.1111/j.1423-0410.2005.00585.x
  • Berliner N, Horwitz M, loughran TP. Congenital and acquired neutropenia. Hematoogy Am Soc Educ Program 2004. pp:63-79. PMid:15561677
  • Janka Ge, lehmberg k. Hemophagocytic lymhohis- tiocytosis: pathogenesis and treatment. Hematology Am Soc Hematol Educ Program 2013;2013:605-11.
There are 15 citations in total.

Details

Primary Language Turkish
Journal Section Research Articles
Authors

Selime Aydoğdu This is me

Ahsen Çelik This is me

Zeynep Karakaş This is me

Publication Date January 1, 2015
Published in Issue Year 2015 Volume: 15 Issue: 1

Cite

APA Aydoğdu, S., Çelik, A., & Karakaş, Z. (2015). Nötropeniye Yaklaşım. Journal of Child, 15(1), 3-9. https://doi.org/10.5222/j.child.2015.003
AMA Aydoğdu S, Çelik A, Karakaş Z. Nötropeniye Yaklaşım. Journal of Child. January 2015;15(1):3-9. doi:10.5222/j.child.2015.003
Chicago Aydoğdu, Selime, Ahsen Çelik, and Zeynep Karakaş. “Nötropeniye Yaklaşım”. Journal of Child 15, no. 1 (January 2015): 3-9. https://doi.org/10.5222/j.child.2015.003.
EndNote Aydoğdu S, Çelik A, Karakaş Z (January 1, 2015) Nötropeniye Yaklaşım. Journal of Child 15 1 3–9.
IEEE S. Aydoğdu, A. Çelik, and Z. Karakaş, “Nötropeniye Yaklaşım”, Journal of Child, vol. 15, no. 1, pp. 3–9, 2015, doi: 10.5222/j.child.2015.003.
ISNAD Aydoğdu, Selime et al. “Nötropeniye Yaklaşım”. Journal of Child 15/1 (January 2015), 3-9. https://doi.org/10.5222/j.child.2015.003.
JAMA Aydoğdu S, Çelik A, Karakaş Z. Nötropeniye Yaklaşım. Journal of Child. 2015;15:3–9.
MLA Aydoğdu, Selime et al. “Nötropeniye Yaklaşım”. Journal of Child, vol. 15, no. 1, 2015, pp. 3-9, doi:10.5222/j.child.2015.003.
Vancouver Aydoğdu S, Çelik A, Karakaş Z. Nötropeniye Yaklaşım. Journal of Child. 2015;15(1):3-9.