Akut Miyeloid Lösemi AML

Year 2012, Volume: 12 Issue: 4, 153 - 158, 01.10.2012

Sema Anak Ezgi Uysalol

https://doi.org/10.5222/j.child.2012.153

Abstract

Akut miyeloid lösemi AML çocuklarda ikinci en sık lösemi türüdür. AML tanısı için kemik iliğinde % 30’un üstünde blast varlığı gereklidir. Destekleyici bakımdaki iyileşmeler- le birlikte yoğunlaştırılmış konvansiyonel kemoterapi çocukluk çağı AML prognozunu iyileştirmiştir. AML olan çocukların tedavisinde gelişmeler, lökomogenezin ve ilaç direncinin altında yatan genetik anormallikler dikkate alı- narak hastalığın biyolojisinin daha iyi anlaşılmasını gerek- tirir. Bu yazımızda AML genetik ve biyolojisine yeni bir bakış açısı sağlayan son çalışmaları, hastalık için risk sınıflaması ve tedavi tartışmalarını ve halen araştırılmakta olan terapötik ajanları özetledik

Keywords

Akut miyeloid lösemi, AML, çocukluk çağı lösemisi

Acute Myelogenous Leukemia AML

Abstract

Acute myelogenous leukemia AML is the second most com- mon leukemia in children. The diagnosis of AML requires the presence of blasts >30% in the bone marrow in most cases. The intensification of conventional chemotherapy along with improvements in supportive care has improved the prognosis in childhood AML. Instead, advances in the treatment of child- ren with AML will require a greater understanding of the biology of the disease, with particular attention to the genetic abnormalities underlying leukemogenesis and drug resistan- ce. In this review, we summarize recent studies that provide new insight into the genetics and biology of AML, discuss risk stratification and therapy for this disease, and profile some of the therapeutic agents currently under investigation

Keywords

Acute myeloid leukaemia, AML, childhood leukaemia

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