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Vinkristine Bağlı Parsiyel İntestinal Obstrüksiyon Tedavisinde Pridostigmin ve Pridoksin Kullanımı: Vaka Sunumu

Year 2012, Volume: 12 Issue: 1, 47 - 49, 01.01.2012

Kezban Karabağ Mustafa Büyükavcı Zuhal Keskin Yıldırım

https://doi.org/10.5222/j.child.2012.047

Abstract

Bir vinka alkaloidi olan vinkristin VCR , çocukluk çağı kanserlerinin tedavisinde yaygın olarak kullanılan bir kemoteropatiktir. Vinkristinin nörotoksik etkileri kullanı- mını sınırlayıcı bir faktördür. Bu nörotoksik etkiler, peri- feral nöropati, otonomik nöropati, kranial sinir felçleri ve ensefalopati olmak üzere dört gruba ayrılmaktadır. Nöropatinin ciddiyeti tedavinin süresi ve toplam doz ile ilişkilidir. Semptomların çoğu ilacın kesilmesi ile düzel- mektedir. Biz burada, daha önce bilinen kalıtsal bir nöro- patisi olmadığı halde VCR tedavisini takiben parsiyel intestinal obstrüksiyon gelişen, pridoksin ve pridostigmin ile tedavi ettiğimiz sekiz yaşında bir erkek vakayı sun- duk

Keywords

Vinkristin nörotoksisite parsiyel intestinal obstrüksiyon pridoksin pridostigmin

References

  • Lanzkowsky PMB. Non-Hodgkin Lymphoma In: Manual of Pediatric Hematology and Oncology, ed. 4. Elsevier Academic Press; 2005:491-511. http://dx.doi.org/10.1016/B978-012088524-4/50020-0
  • Balıs FM, Holcenberg JS, Blaney SM. General Principles of Chemotherapy In: Principles and Practice of Pediatric Oncology, ed. 4. Philadelphia: Lippincott Williams & Wilkins; 2002:237-308.
  • Wang MS, Wu Y, Culver DG, Glass JD. Pathogenesis of axonal degeneration: parallels between Wallerian degenerati- on and vincristine neuropathy. J Neuropathol Exp Neurol 2000;59(7):599-606. PMid:10901231
  • Ravula SK, Wang MS, McClain MA, Asress SA, Frazier B, Glass JD. Spatiotemporal localization of injury potentials in DRG neurons during vincristine-induced axonal degeneration. Neurosci Lett 2007;19;415(1):34-9. Epub 2007 Jan 10. Erratum in: Neurosci Lett 2007;417(2):217. http://dx.doi.org/10.1016/j.neulet.2007.01.009 PMid:17267126 PMCid:2665290
  • Silva A, Wang Q, Wang M, et al. Evidence for direct axonal toxicity in vincristine neuropathy. J Peripher Nerv Syst 2006;11:211-6. http://dx.doi.org/10.1111/j.1529-8027.2006.0090.x PMid:16930282
  • Quasthoff S, Hartung HP. Chemotherapy-induced peripheral neuropathy. J Neurol 2002;249:9-17. http://dx.doi.org/10.1007/PL00007853 PMid:11954874
  • Bay A, Yılmaz C, Yılmaz N, Öner AF. Vincristine induced cranial polyneuropathy. Indian J Pediatr 2006;73:531-3. http://dx.doi.org/10.1007/BF02759902
  • Özyürek H, Türker H, Akbalık M, Bayrak AO, Ince H, Duru F. Pyridoxine and pyridostigmine treatment in vincristine-induced neuropathy. Pediatr Hematol Oncol 2007;24(6):447-52. http://dx.doi.org/10.1080/08880010701451327 PMid:17710662
  • Ikehara O. Vincristine-induced paralytic ileus: role of fibe- roptic colonoscopy and prostaglandin F2 alpha. Am J Gastroenterol 1992;87:207-10. PMid:1734699
  • Garewal HS, Dalton WS. Metoclopramide in vincristine- induced ileus. Cancer Treat Rep 1985;69:1309-11. PMid:3867404
  • Muller L, Kramm CM, Tenenbaum T, Wessalowski R, Gobel U. Treatment of vincristine-induced bilateral ptosis with pyridoxine and pyridostigmine. Pediatr Blood Cancer 2004;42:287-8. http://dx.doi.org/10.1002/pbc.10301

Pyridoxine and Pyridostigmine Use in Vincristine-Induced Partial Intestinal Obstruction: Case Report

Year 2012, Volume: 12 Issue: 1, 47 - 49, 01.01.2012

Kezban Karabağ Mustafa Büyükavcı Zuhal Keskin Yıldırım

https://doi.org/10.5222/j.child.2012.047

Abstract

The vinca alkoloid, vincristine VCR is a commonly used chemotherapeutic agent in the treatment of pediatric malignancies. Its neurotoxic effects are the limiting fac- tors for the use of the drug. Neurotoxic effects may be divided into four groups as peripheral neuropathy, auto- nomic neuropathy, cranial nerve neuropathy and encep- halopathy. The severity of neuropathy is related to the total dose and duration of the therapy. Most of the symptoms improves after withdrawal of the drug. We pre- sented an 8 year-old boy without hereditary neuropathy, who suffered from partial intestinal obstruction following vincristine therapy and treated by using pyridoxine and pyridostigmine

Keywords

Vincristine neurotoxicity partial intestinal obstruction pyridoxine pyridostigmine

References

  • Lanzkowsky PMB. Non-Hodgkin Lymphoma In: Manual of Pediatric Hematology and Oncology, ed. 4. Elsevier Academic Press; 2005:491-511. http://dx.doi.org/10.1016/B978-012088524-4/50020-0
  • Balıs FM, Holcenberg JS, Blaney SM. General Principles of Chemotherapy In: Principles and Practice of Pediatric Oncology, ed. 4. Philadelphia: Lippincott Williams & Wilkins; 2002:237-308.
  • Wang MS, Wu Y, Culver DG, Glass JD. Pathogenesis of axonal degeneration: parallels between Wallerian degenerati- on and vincristine neuropathy. J Neuropathol Exp Neurol 2000;59(7):599-606. PMid:10901231
  • Ravula SK, Wang MS, McClain MA, Asress SA, Frazier B, Glass JD. Spatiotemporal localization of injury potentials in DRG neurons during vincristine-induced axonal degeneration. Neurosci Lett 2007;19;415(1):34-9. Epub 2007 Jan 10. Erratum in: Neurosci Lett 2007;417(2):217. http://dx.doi.org/10.1016/j.neulet.2007.01.009 PMid:17267126 PMCid:2665290
  • Silva A, Wang Q, Wang M, et al. Evidence for direct axonal toxicity in vincristine neuropathy. J Peripher Nerv Syst 2006;11:211-6. http://dx.doi.org/10.1111/j.1529-8027.2006.0090.x PMid:16930282
  • Quasthoff S, Hartung HP. Chemotherapy-induced peripheral neuropathy. J Neurol 2002;249:9-17. http://dx.doi.org/10.1007/PL00007853 PMid:11954874
  • Bay A, Yılmaz C, Yılmaz N, Öner AF. Vincristine induced cranial polyneuropathy. Indian J Pediatr 2006;73:531-3. http://dx.doi.org/10.1007/BF02759902
  • Özyürek H, Türker H, Akbalık M, Bayrak AO, Ince H, Duru F. Pyridoxine and pyridostigmine treatment in vincristine-induced neuropathy. Pediatr Hematol Oncol 2007;24(6):447-52. http://dx.doi.org/10.1080/08880010701451327 PMid:17710662
  • Ikehara O. Vincristine-induced paralytic ileus: role of fibe- roptic colonoscopy and prostaglandin F2 alpha. Am J Gastroenterol 1992;87:207-10. PMid:1734699
  • Garewal HS, Dalton WS. Metoclopramide in vincristine- induced ileus. Cancer Treat Rep 1985;69:1309-11. PMid:3867404
  • Muller L, Kramm CM, Tenenbaum T, Wessalowski R, Gobel U. Treatment of vincristine-induced bilateral ptosis with pyridoxine and pyridostigmine. Pediatr Blood Cancer 2004;42:287-8. http://dx.doi.org/10.1002/pbc.10301
There are 11 citations in total.

Details

Primary Language Turkish
Journal Section Research Articles
Authors

Kezban Karabağ This is me

Mustafa Büyükavcı This is me

Zuhal Keskin Yıldırım This is me

Publication Date January 1, 2012
Published in Issue Year 2012 Volume: 12 Issue: 1

Cite

APA Karabağ, K., Büyükavcı, M., & Keskin Yıldırım, Z. (2012). Vinkristine Bağlı Parsiyel İntestinal Obstrüksiyon Tedavisinde Pridostigmin ve Pridoksin Kullanımı: Vaka Sunumu. Journal of Child, 12(1), 47-49. https://doi.org/10.5222/j.child.2012.047
AMA Karabağ K, Büyükavcı M, Keskin Yıldırım Z. Vinkristine Bağlı Parsiyel İntestinal Obstrüksiyon Tedavisinde Pridostigmin ve Pridoksin Kullanımı: Vaka Sunumu. Journal of Child. January 2012;12(1):47-49. doi:10.5222/j.child.2012.047
Chicago Karabağ, Kezban, Mustafa Büyükavcı, and Zuhal Keskin Yıldırım. “Vinkristine Bağlı Parsiyel İntestinal Obstrüksiyon Tedavisinde Pridostigmin Ve Pridoksin Kullanımı: Vaka Sunumu”. Journal of Child 12, no. 1 (January 2012): 47-49. https://doi.org/10.5222/j.child.2012.047.
EndNote Karabağ K, Büyükavcı M, Keskin Yıldırım Z (January 1, 2012) Vinkristine Bağlı Parsiyel İntestinal Obstrüksiyon Tedavisinde Pridostigmin ve Pridoksin Kullanımı: Vaka Sunumu. Journal of Child 12 1 47–49.
IEEE K. Karabağ, M. Büyükavcı, and Z. Keskin Yıldırım, “Vinkristine Bağlı Parsiyel İntestinal Obstrüksiyon Tedavisinde Pridostigmin ve Pridoksin Kullanımı: Vaka Sunumu”, Journal of Child, vol. 12, no. 1, pp. 47–49, 2012, doi: 10.5222/j.child.2012.047.
ISNAD Karabağ, Kezban et al. “Vinkristine Bağlı Parsiyel İntestinal Obstrüksiyon Tedavisinde Pridostigmin Ve Pridoksin Kullanımı: Vaka Sunumu”. Journal of Child 12/1 (January 2012), 47-49. https://doi.org/10.5222/j.child.2012.047.
JAMA Karabağ K, Büyükavcı M, Keskin Yıldırım Z. Vinkristine Bağlı Parsiyel İntestinal Obstrüksiyon Tedavisinde Pridostigmin ve Pridoksin Kullanımı: Vaka Sunumu. Journal of Child. 2012;12:47–49.
MLA Karabağ, Kezban et al. “Vinkristine Bağlı Parsiyel İntestinal Obstrüksiyon Tedavisinde Pridostigmin Ve Pridoksin Kullanımı: Vaka Sunumu”. Journal of Child, vol. 12, no. 1, 2012, pp. 47-49, doi:10.5222/j.child.2012.047.
Vancouver Karabağ K, Büyükavcı M, Keskin Yıldırım Z. Vinkristine Bağlı Parsiyel İntestinal Obstrüksiyon Tedavisinde Pridostigmin ve Pridoksin Kullanımı: Vaka Sunumu. Journal of Child. 2012;12(1):47-9.