Renal Hiperkalsiürili Çocuklarda Osteoporoz Sıklığı

Year 2010, Volume: 10 Issue: 1, 33 - 37, 01.01.2010

Dicle Şener Şeyma Ekmekçi Ahmet Nayır Sema Cantez

https://doi.org/10.5222/j.child.2010.033

Abstract

Amaç : Renal hiperkalsiürili çocuklarda sessiz olarak seyreden, fazla önemsenmeyen osteoporoz sıklığını araştırmak amacıyla İTF Çocuk Nefroloji BD’de renal hiperkalsiüri tanısıyla takipli, 3-10 yaş arası 20 çocuk çalışmaya kabul edildi. Yöntemler: Kemik mineral yoğunlukları DEXA cihazı ile ölçüldü. Vakaların böbrek fonksiyon testleri, serum elektrolitleri, serum alkalen fosfataz, kalsiyum, fosfor, parathormon, osteokalsin, kalsitriol düzeyleri, idrar kalsiyum/ kreatinin, 24 saatlik idrar kalsiyum atılımları incelendi. Bulgular: Çocukların 5’i % 25 osteoporotik, 4’ü % 20 osteopenik bulundu. Kemik mineral yoğunlukları ile 24 saatlik idrar kalsiyum atılımları, spot idrar kalsiyum/kreatinin oranları arasında negatif yönde güçlü ilişki saptandı r= -0.587, p= 0.007 , r= -0.629, p= 0.03 . Sonuç: Sonuçlar şimdiye kadar yapılan benzer çalışmalarla karşılaştırıldı.Sonuçlarımız renal hiperkalsiürili hastalarda osteoporozun önemli bir sorun olduğunu göstermektedir.

Keywords

Hiperkalsiüri, osteoporoz, kalsiyum, fosfor, sodyum, urolithiazis

The Prevalence of Osteoporosis in Renal Hypercalciuric Children

Abstract

Objective: To determine the prevalence of silent osteoporosis which is considered to be unimportant in renal hypercalciuric children, 20 children between 3-10 years of age who were followed by ITF Department of Pediatric Nephrology with the diagnosis of renal hypercalciuria included in the study. Methods: Bone mineral densities measured by DEXA scanner. Renal function tests; serum electrolit, alkaline phosphatase, calcium, phophorus, parathormone, calcitriol levels; urinary calcium to creatinin Ca/Cr ratios, daily urinary calcium excretions investigated. Results: Twenty-five percent of children were osteoporotic, and % 20 of them were osteopenic. Lumbar spine bone mineral density measurments were inversely correlated with urine Ca/Cr ratios r= -0.587, p=0.007 ; and daily urinary calcium levels r= -0.629, p=0.03 . Conclusion: Our results support the importance of osteoporosis in renal hypercalciuric children.

Keywords

Hypercalciuria, osteoporosis, calcium, phosphorus, sodium, renal calculi

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