Lamotrijin İlişkili Dress Sendromu: Bir Vaka Sunumu

Year 2009, Volume: 9 Issue: 3, 142 - 146, 01.07.2009

Ebru Arık Yılmaz Serap Özmen Nilden Tuygun Tayfun Giniş Gönül Tanır

Abstract

Dress sendromu drug rash with eosinophilia and systemic symptoms ateş, cilt döküntüsü, iç organ tutulumuyla karakterize yaşamı tehdit edebilen ender, akut başlangıçlı, şiddetli bir ilaç reaksiyonudur. En sık nedenleri aromatik antikonvülzanlar ve sülfonamidlerdir. Yeni bir antikonvül- zan olan lamotrijin de ender olarak Dress sendromuna yol açabilir. Valproat ile birlikte kullanıldığında lamotrijin ile ilişkili cilt döküntülerinin sıklığı artış gösterebilmektedir. Burada epilepsi tanısıyla valproat kullanırken, lamotrijin tedavisi eklendikten 12 gün sonra ateş, karın ağrısı, cilt döküntüsü yakınmaları ile başvurup, Dress sendromu tanı- sı konulan ve sistemik kortikosteroid ve intravenöz immung- lobulin IVIG ile başarılı bir şekilde tedavi edilen sekiz yaşında bir kız vaka sunulmaktadır

Keywords

Dress sendromu, lamotrijin, valproat, çocuk

Lamotrigine Associated Dress Syndrome: A Case Report

Abstract

Dress syndrome drug rash with eosinophilia and systemic symptoms is a rare, acute, severe, life-threatening drug reaction; characterized by fever, rash, internal organ involvement. Aromatic anticonvulsants and sulphonamides are most frequent causes. Lamotrigine, a new anticonvul- sant, is also known to be a rare cause. Skin rashes associ- ated with lamotrigine is more common when combined with valproate. Here we represent a case of an eight-years- old girl diagnosed as Dress syndrome who suffered from fever, rash, stomachache after 12 days of adding lamotri- gine to her valproate treatment which was administered for her epilepsy. She was successfuly treated with systemic corticosteroid and intravenous immunoglobulin IVIG

Keywords

Dress syndrome, lamotrigine, valproat, children

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