Hepatitis B antibody Response in Patients with Celiac and Inflammatory Bowel Diseases

Year 2023, Volume: 23 Issue: 1, 79 - 83, 27.03.2023

Didem Gülcü Taşkın

https://doi.org/10.26650/jchild.2023.1178024

Abstract

Objective: In some patient groups, special vaccination protocols need to be followed for vaccine preventable diseases like Hepatitis B (HB). We aimed to evaluate the antibody response against the HB vaccine in Inflammatory Bowel Disease (IBD) and Celiac Disease (CD) patients, emphasizing the efficiency of the routine vaccine protocol for these patient groups. Material and Methods: We included 219 patients (CD and IBD) and 125 in the healthy control group (HCG). The patients who had received only 3 doses of HB vaccine were included. The design of the study is retrospective in manner. Results: The patients age with positive antibody (anti-HBs titers) were lower than in patients with negative anti-HBs titers. In patients having positive anti-HBs titers, both the serum glutamic-oxaloacetic transaminase (SGOT) and serum glutamic-pyruvic transaminase (SGPT) values were found to be significantly higher. Result: Following periodic control measures and administering an additional dose of the HB vaccine is required because the antibody protection decreases as the illness continues to progress with the increasing age of the patients.

Keywords

Celiac disease (CD), Hepatitis B (HB) vaccine, antibody (AntiHBs titers), inflammatory bowel disease (IBD), pediatric

Supporting Institution

No one

Çölyak Hastaları ve İnflamatuvar Bağırsak Hastalarında Hepatit B Antikor Yanıtı

Abstract

Amaç: Bazı hasta gruplarında özellikle Hepatit B virüs enfeksiyonu gibi, aşı ile önlenebilen hastalıklar açısından özel aşılama protokollerine ihtiyaç vardır. Biz çalışmamızda İnflammatuvar Bağırsak Hastalığı (İBH) ve Çölyak Hastalığında (ÇH) Hepatit B aşı cevabını değerlendirerek bu hasta gruplarında kullanılan aşı protokolünün hastaları korumadaki etkinliğini araştırmak istedik. Gereç ve Yöntem: Çalışmaya toplam 219 kronik hastalığı olan çocuk (ÇH ve İBH) ve 125 sağlıklı (kontrol grubu) çocuk dahil edildi. Tüm gruplarda sadece 3 doz Hepatit B aşısı yapılmış olan hastalar çalışmaya dahil edilerek ek doz yapılmış ya da eksik doz uygulanmış hastalar çalışma dışında bırakıldı. Çalışma retrospektif olarak tasarlanmıştır. Bulgular: Çalışmaya dahil edilen hastaların anti HBs titreleri değerlendirildiğinde tüm gruplarda Anti HBs titresi pozitif olan hastaların yaş ortalamaları Anti HBs titresi negatif olan hastalara kıyasla daha düşük idi. Hastaların Anti HBs titresi pozitif olanlar değerlendirildiğinde Aspartat aminotransferaz (AST) ve Alanin aminotransferaz (ALT) değerleri daha yüksek bulundu. Sonuç: Hastalarda antikor koruyuculuğunun zamanla azaldığı gösterilmiştir. Özellikle infeksiyon açısından risk taşıyan, immunsüpresif ilaç kullanmak zorunda olan, ÇH ve İBH, gibi hasta gruplarında aşı titresi hastalık seyri sırasında belirli aralıklar ile takip edilmeli ve gerekirse ek doz aşılama düşünülmelidir.

Keywords

Çölyak Hastalığı (ÇH), Hepatit B virüs aşısı, Anti HBs antikor titresi, İnflammatuvar bağırsak hastalığı (İBH), çocuk

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