Severe Thrombocytopenia Associated with Low dose of Intracoronary Tirofiban

Abstract

Tirofiban is a glycoprotein IIb/IIIa inhibitor and is an adjunct in the treatment of patients with acute coronary syndrome. Its main side effects are bleeding and thrombocytopenia. Severe thrombocytopenia is a rare but serious complication of tirofiban therapy, including when administered at low intracoronary doses in interventional cardiac procedures. The pathogenesis is largely immune-mediated and can result in abrupt and profound platelet count declines. Early and frequent platelet monitoring, prompt discontinuation of the drug, and supportive care remain critical to managing this adverse effect. In this case report, we present a case of severe thrombocytopenia that occurred in a 74-year-old male patient with non-ST segment elevation myocardial infarction following administration of a very low dose of tirofiban.

Keywords

• case report
• platelets
• thrombocytopenia
• tirofiban

Düşük doz İntrakoroner Tirofiban Tedavisi Sonrası Gelişen Şiddetli Trombositopeni

Abstract

Tirofiban, glikoprotein IIb/IIIa inhibitörüdür. Akut koroner sendromlu hastaların tedavisinde yardımcı bir ilaçtır. Başlıca yan etkileri kanama ve trombositopenidir. Şiddetli trombositopeni, tirofiban tedavisinin nadir ancak ciddi bir komplikasyonudur. Bu durum girişimsel kardiyak işlemlerde düşük intrakoroner dozlarda uygulandığında bile ortaya çıkabilir. Patogenezi büyük ölçüde immün aracılıdır. Trombosit sayısında ani ve şiddetli düşüşlere neden olabilir. Bu yan etkinin yönetimi için erken ve sık trombosit takibi, ilacın derhal kesilmesi ve destekleyici bakım kritik önem taşımaktadır. Bu vaka raporunda, ST segment yükselmesiz miyokard enfarktüsü olan 74 yaşında bir erkek hastada çok düşük dozda tirofiban uygulamasının ardından ortaya çıkan şiddetli trombositopeni vakasını sunuyoruz.

Keywords

• olgu sunumu
• platelet
• trombositopeni
• tirofiban

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