Case Report
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Year 2019, , 105 - 107, 01.10.2019
https://doi.org/10.33706/jemcr.517021

Abstract

References

  • Catherine Ulbricht et al. An Evidence-Based Systematic Review of Goji (Lycium spp.) by the Natural Standard Research Collaboration, Journal of Dietary Supplements (2015),12:2, 184-240.
  • Amagase H, Nance DM. Lycium barbarum increases caloric expenditure and decreases waist circumference in healthy overweight men and women: pilot study. J Am Coll Nutr. 2011;30(5):304–309.
  • Yu MS, Ho YS, So KF, Yuen WH, Chang RC. Cytoprotective effects ofLycium barbarum against reducing stress on endoplasmic reticulum. Int J Mol Med. 2006;17(6):1157–1161.
  • Larramendi, C.H., García-Abujeta, J.L., Vicario, S. et al, Goji berries (Lycium barbarum): risk of allergic reactions in individuals with food allergy. J Investig Allergol Clin Immunol. 2012;22:345–350.
  • Daniela Zauli, Maria Grazia Mirarchi. Anaphylaxis induced by Goji berries. Ann Allergy Asthma Immunol. 2015;114: 535-536.
  • S Monzón Ballarín, MA López-Matas, D Sáenz Abad, N Pérez-Cinto, J Carnés. Anaphylaxis Associated With the Ingestion of Goji Berries (Lycium barbarum). J Investig Allergol Clin Immunol 2011; Vol. 21(7): 567-570
  • Potterat O. Goji (Lycium barbarum and L. chinense): phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity. Planta Med. 2010;76(1):7–19.
  • Rivera CA, Ferro CL, Bursua AJ, Gerber BS. Probable interaction between Lycium barbarum (goji) and warfarin. Pharmacotherapy. 2012;32(3):e50–e53.
  • Lam AY, Elmer GW, Mohutsky MA. Possible interaction between warfarin and Lycium barbarum L. Ann Pharmacother. 2001;35(10):1199–1201.
  • Franco M, Monmany J, Domingo P, Turbau M. Autoimmune hepatitis triggered by consumption of goji berries. Med Clin (Barc.) 2012;139(7):320–321.
  • Arroyo-Martinez Q, Saenz MJ, Arguelles Arias F, Acosta MS. Lycium barbarum: a new hepatotoxic “natural” agent? Dig Liver Dis. 2011;43(9):749.
  • Kim HP, Lee EJ, Kim YC, Kim J, Kim HK, Park JH, Kim SY, Kim YC. Zeaxanthin dipalmitate from Lycium chinense fruit reduces experimentally induced hepatic fibrosis in rats. Biol Pharm Bull. 2002;25(3):390–392.
  • Lycium barbarum extract provides effective protection against paracetamol-induced acute hepatotoxicity in rats. Int J Clin Exp Med 2015;8(5):7898-7905. Ercan Gündüz, Recep Dursun, Yılmaz Zengin, Mustafa İçer, Hasan Mansur Durgun, Ayşe Kanıcı, İbrahim Kaplan, Ulaş Alabalık, Hüseyin Gürbüz, Cahfer Güloğlu.

A New Hepatotoxic Agent : Goji Berry

Year 2019, , 105 - 107, 01.10.2019
https://doi.org/10.33706/jemcr.517021

Abstract

ABSTRACT



INTRODUCTION: Goji berry has long been used as a
healthy aliment for healthy vision, strengthening the immune system, protecting
the liver, improving circulation, remedy for diabetes, enhancing sexual
performance and general health. But there are not enough study on its
constituents, pharmacology and safety.



CASE REPORT: This case report describes a 24-year-old female patient
was admitted  to emergency service due to
complaints of nausea, vomiting and abdominal pain. Ictherus at sclera and
sensivitiy on the right upper quadrant of abdomen were found on the physical
examination.
Blood tests revealed high liver function tests. The causes of jaundice and impaired liver
function were all excluded and toxic hepatitis
due to goji berry consumption was
considered in patient.



CONCLUSION: Goji berry is a traditional
nutrient that is increasingly used for its various effects.
To date, there are some articles declared
allergic reactions as toxic effect. To our knowledge this case is the first
publication that goji berries can be toxic to the liver. Although larger
studies are required, it should be kept in mind that liver toxicity may occur
during intensive use.

References

  • Catherine Ulbricht et al. An Evidence-Based Systematic Review of Goji (Lycium spp.) by the Natural Standard Research Collaboration, Journal of Dietary Supplements (2015),12:2, 184-240.
  • Amagase H, Nance DM. Lycium barbarum increases caloric expenditure and decreases waist circumference in healthy overweight men and women: pilot study. J Am Coll Nutr. 2011;30(5):304–309.
  • Yu MS, Ho YS, So KF, Yuen WH, Chang RC. Cytoprotective effects ofLycium barbarum against reducing stress on endoplasmic reticulum. Int J Mol Med. 2006;17(6):1157–1161.
  • Larramendi, C.H., García-Abujeta, J.L., Vicario, S. et al, Goji berries (Lycium barbarum): risk of allergic reactions in individuals with food allergy. J Investig Allergol Clin Immunol. 2012;22:345–350.
  • Daniela Zauli, Maria Grazia Mirarchi. Anaphylaxis induced by Goji berries. Ann Allergy Asthma Immunol. 2015;114: 535-536.
  • S Monzón Ballarín, MA López-Matas, D Sáenz Abad, N Pérez-Cinto, J Carnés. Anaphylaxis Associated With the Ingestion of Goji Berries (Lycium barbarum). J Investig Allergol Clin Immunol 2011; Vol. 21(7): 567-570
  • Potterat O. Goji (Lycium barbarum and L. chinense): phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity. Planta Med. 2010;76(1):7–19.
  • Rivera CA, Ferro CL, Bursua AJ, Gerber BS. Probable interaction between Lycium barbarum (goji) and warfarin. Pharmacotherapy. 2012;32(3):e50–e53.
  • Lam AY, Elmer GW, Mohutsky MA. Possible interaction between warfarin and Lycium barbarum L. Ann Pharmacother. 2001;35(10):1199–1201.
  • Franco M, Monmany J, Domingo P, Turbau M. Autoimmune hepatitis triggered by consumption of goji berries. Med Clin (Barc.) 2012;139(7):320–321.
  • Arroyo-Martinez Q, Saenz MJ, Arguelles Arias F, Acosta MS. Lycium barbarum: a new hepatotoxic “natural” agent? Dig Liver Dis. 2011;43(9):749.
  • Kim HP, Lee EJ, Kim YC, Kim J, Kim HK, Park JH, Kim SY, Kim YC. Zeaxanthin dipalmitate from Lycium chinense fruit reduces experimentally induced hepatic fibrosis in rats. Biol Pharm Bull. 2002;25(3):390–392.
  • Lycium barbarum extract provides effective protection against paracetamol-induced acute hepatotoxicity in rats. Int J Clin Exp Med 2015;8(5):7898-7905. Ercan Gündüz, Recep Dursun, Yılmaz Zengin, Mustafa İçer, Hasan Mansur Durgun, Ayşe Kanıcı, İbrahim Kaplan, Ulaş Alabalık, Hüseyin Gürbüz, Cahfer Güloğlu.
There are 13 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Case Report
Authors

Derya Yalçın Yılmaz 0000-0002-5553-155X

Kıvanç Karaman 0000-0002-4105-2785

Yunus Emre Özlüer 0000-0001-8297-7525

Selçuk Eren Çanakçı 0000-0002-2795-0714

Ahmet Tunç Deniz 0000-0003-2240-1270

Publication Date October 1, 2019
Submission Date January 24, 2019
Published in Issue Year 2019

Cite

APA Yalçın Yılmaz, D., Karaman, K., Özlüer, Y. E., Çanakçı, S. E., et al. (2019). A New Hepatotoxic Agent : Goji Berry. Journal of Emergency Medicine Case Reports, 10(4), 105-107. https://doi.org/10.33706/jemcr.517021
AMA Yalçın Yılmaz D, Karaman K, Özlüer YE, Çanakçı SE, Deniz AT. A New Hepatotoxic Agent : Goji Berry. Journal of Emergency Medicine Case Reports. October 2019;10(4):105-107. doi:10.33706/jemcr.517021
Chicago Yalçın Yılmaz, Derya, Kıvanç Karaman, Yunus Emre Özlüer, Selçuk Eren Çanakçı, and Ahmet Tunç Deniz. “A New Hepatotoxic Agent : Goji Berry”. Journal of Emergency Medicine Case Reports 10, no. 4 (October 2019): 105-7. https://doi.org/10.33706/jemcr.517021.
EndNote Yalçın Yılmaz D, Karaman K, Özlüer YE, Çanakçı SE, Deniz AT (October 1, 2019) A New Hepatotoxic Agent : Goji Berry. Journal of Emergency Medicine Case Reports 10 4 105–107.
IEEE D. Yalçın Yılmaz, K. Karaman, Y. E. Özlüer, S. E. Çanakçı, and A. T. Deniz, “A New Hepatotoxic Agent : Goji Berry”, Journal of Emergency Medicine Case Reports, vol. 10, no. 4, pp. 105–107, 2019, doi: 10.33706/jemcr.517021.
ISNAD Yalçın Yılmaz, Derya et al. “A New Hepatotoxic Agent : Goji Berry”. Journal of Emergency Medicine Case Reports 10/4 (October 2019), 105-107. https://doi.org/10.33706/jemcr.517021.
JAMA Yalçın Yılmaz D, Karaman K, Özlüer YE, Çanakçı SE, Deniz AT. A New Hepatotoxic Agent : Goji Berry. Journal of Emergency Medicine Case Reports. 2019;10:105–107.
MLA Yalçın Yılmaz, Derya et al. “A New Hepatotoxic Agent : Goji Berry”. Journal of Emergency Medicine Case Reports, vol. 10, no. 4, 2019, pp. 105-7, doi:10.33706/jemcr.517021.
Vancouver Yalçın Yılmaz D, Karaman K, Özlüer YE, Çanakçı SE, Deniz AT. A New Hepatotoxic Agent : Goji Berry. Journal of Emergency Medicine Case Reports. 2019;10(4):105-7.