Severe Theophylline Intoxication, Rhabdomyolysis, Disseminated Intravascular Coagulopathy And Death

Abstract

Background: Severe intoxication which is induced by theophylline which is used in the treatments of broncospastic pulmonary diseases is quite rare. In literature, there is limited number of rhabdomyolysis cases induced by theophylline toxicity. The statement of disseminated intravascular coagulopathy which develops after theophylline intoxication has not been detected in the literature.Case report: We present the case which has resulted with rhabdomyolysis, disseminated intravascular coagulopathy and death after overdose theophylline intake of a female patient at the age of seventeen.Conclusion: The overdose theophylline intake can cause quite mortal toxicity as a result of negative effects it causes on cardiovascular, neurological and metabolic systems. It should not be forgotten that in severe intoxications, rhabdomyolysis and disseminated intravascular coagulopathy can be developed, although the patient’s condition is good, she/he should be monitored with close monitorization under intensive care conditions

Keywords

• Emergency department
• Disseminated intravascular coagulopathy
• Theophylline

Şiddetli Teofilin Zehirlenmesi, Rabdomiyoliz,Dissemine İntravasküler Koagülopati ve Ölüm

Abstract

Giriş: Bronkospastik akciğer hastalıklarının tedavisinde kullanılan teofiline bağlı şiddetli zehirlenme oldukça nadirdir. Literatürde teofilin toksisitesine bağlı sınırlı sayıda rabdomiyoliz olgusu mevcuttur. Teofilin zehirlenmesi sonrası gelişen dissemine intravasküler koagülopati tablosu literatürde saptanmamıştır. Olgu: On yedi yaşında bayan hastada yüksek doz teofilin alımı sonrası, rabdomiyoliz, dissemine intravasküler koagülopati ve ölümle sonuçlanan olguyu sunuyoruz. Sonuç: Yüksek doz teofilin alımı, kardiyovasküler, nörolojik ve metabolik sistemler üzerinde meydana getirdiği olumsuz etkiler sonucu oldukça ölümcül seyreden toksisiteye neden olabilmektedir. Şiddetli zehirlenmelerde rabdomiyoliz ve dissemine intravasküler koagülopati gelişebileceği unutulmamalı, hastanın durumu iyi olsa bile yoğun bakım şartlarında yakın monitorizasyonla takip edilmelidir

Keywords

• Acil servis
• Dissemine intravasküler koagülopati
• Teofilin

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