Amantadin İnfüzyonu Sonrası Nörolojik İyileşme

Abstract

Amantadin, N-methyl-D-aspartate antagonist özelliği ile dopaminerjik etki gösteren bir ajandır. Dopaminerjik ajanlar; psikiyatrik hastalıkların tamamlayıcı, Parkinson Hastalığı ve bilinç bozuklukları tedavisinde ve influenza profilaksisinde başarıyla kullanılmaktadır. Bu olgu sunumunda nedeni tam olarak belirlenemeyen GKS 7 olan komadaki bir hastada izleminin 10. gününde amantadin infüzyonu başlandı. Amantadin infüzyonunun 2. gününden itibaren dramatik düzelme görülen hasta izleminin 21. günü GKS 15 olarak taburcu edildi. Amantadin tedavisi, koma hastalarında iyileşmeyi hızlandırdığı ve arttırdığı için standart tedaviye ilave olarak kullanılabilir.

Keywords

• Dopaminerjik ajan, amantadin, bilinç bozukluğu

The Neurological Improvement of a Patient after Amantadine Infusion

Abstract

Amantadine is a dopaminergic agent with possible N-methylD-aspartate antagonist effects. Dopaminergic agents have been succesfully used for many purposes, including prophylaxis for influenza, adjunctive therapy for psychiatric diseases, treatment for Parkinson Disease, and treatment for disorders of consciousness. In this case report, amantadine infusion was started in a patient whose unconciousness could not be identified for ten days. A dramatic recovery was detected on the second day following amantadine infusion. The patient was discharged on the twenty-first treatment day with a 15 GCS score. Conclusion: Amantadine may be added to the standard therapy in comatose patients as it accelerates neurological functional recovery

Keywords

• Dopaminergic agents, amantadine, consciousness

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