Hipotiroidiye Bağlı Gelişen Rabdomiyoliz: İki Olgu Sunumu

Abstract

Giriş: Rabdomiyoliz iskelet kasının travmatik veya non-travmatik pek çok hastalık sonucunda görülen klinik ve biyokimyasal bir sendromudur. Rabdomiyolizin etiyolojisinde; herediter kas enzim eksiklikleri, kolşisin, statinler ve lityum gibi ilaçlar, konvülziyonlar, travma, viral enfeksiyonlar, aşırı egzersiz gibi nedenler bulunmaktadır. Hipotiroidi; tiroid hormonlarının yetersiz salgılanması sonucunda gelişen bir klinik tablodur. Olgu Sunumu: Bu yazımızda hipotiroidisi olan ve tedavi almamış iki hastada hipotiroidiye bağlı gelişen rabdomiyoliz olgusu sunulmaktadır. Hastalarımızda hormon replasman tedavisi ile kliniğin hızla düzeldiği ve kas enzimlerinin normale gerilediği görülmektedir. Sonuç: Hipotiroidi gelişen ve tedavi almayan hastalarda solunum merkezinin depresyonu, kardiyomegali, perikardial tamponad, angina pektoris, konjestif kalp yetersizliği, rabdomiyoliz gelişebileceği unutulmamalıdır.

Keywords

• Hipotiroidi, rabdomiyoliz

Rhabdomyolysis Developed Due to Hypothyroidism: Two Case Reports

Abstract

Introduction: Rhabdomyolysis is a clinical and biochemical syndrome, resulting from the exposure of the skeletal muscle to toxic substances or from diseases. The etiology of the rhabdomyolysis consists of the hereditary deficiency of muscle enzymes; drugs like colchicine, statins, and lithium; convulsion; trauma; viral infections; excessive exercise; and so on. Hypothyroidism is a clinical setting in which thyroid hormones are produced and secreted ineffectively.Case Report: In our article, two cases of rhabdomyolysis due to hypothyroidism are presented who got the diagnosis of hypothyroidism but had not gotten any treatment. It was seen that the clinical signs and symptoms of the patients recovered quickly with the beginning of hormone replacement, and muscle enzymes decreased back to normal levels.Conclusion: It should be remembered that depression of the respiratory system, cardiomegaly, pericardial tamponade, angina pectoris, congestive heart failure, and rhabdomyolysis can develop in those patients who are diagnosed with hypothyroidism and yet not treated properly

Keywords

• Hypothyroidism, rhabdomyolysis

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