Hipotiroidiye Bağlı Gelişen Rabdomiyoliz: İki Olgu Sunumu

Year 2014, Volume: 5 Issue: 2, 63 - 65, 01.02.2014

Abdullah Sakin , Kenan Çelik Ayşegül Sakin Savaş Öztürk

https://izlik.org/JA25MC48ED

Abstract

Giriş: Rabdomiyoliz iskelet kasının travmatik veya non-travmatik
pek çok hastalık sonucunda görülen klinik ve biyokimyasal bir
sendromudur. Rabdomiyolizin etiyolojisinde; herediter kas enzim
eksiklikleri, kolşisin, statinler ve lityum gibi ilaçlar, konvülziyonlar,
travma, viral enfeksiyonlar, aşırı egzersiz gibi nedenler bulunmaktadır.
Hipotiroidi; tiroid hormonlarının yetersiz salgılanması sonucunda
gelişen bir klinik tablodur.
Olgu Sunumu: Bu yazımızda hipotiroidisi olan ve tedavi almamış
iki hastada hipotiroidiye bağlı gelişen rabdomiyoliz olgusu sunulmaktadır.
Hastalarımızda hormon replasman tedavisi ile kliniğin
hızla düzeldiği ve kas enzimlerinin normale gerilediği görülmektedir.
Sonuç: Hipotiroidi gelişen ve tedavi almayan hastalarda solunum
merkezinin depresyonu, kardiyomegali, perikardial tamponad,
angina pektoris, konjestif kalp yetersizliği, rabdomiyoliz gelişebileceği
unutulmamalıdır.

Keywords

Hipotiroidi , rabdomiyoliz

Rhabdomyolysis Developed Due to Hypothyroidism: Two Case Reports

https://izlik.org/JA25MC48ED

Abstract

Introduction: Rhabdomyolysis is a clinical and biochemical syndrome, resulting from the exposure of the skeletal muscle to toxic substances or from diseases. The etiology of the rhabdomyolysis consists of the hereditary deficiency of muscle enzymes; drugs like colchicine, statins, and lithium; convulsion; trauma; viral infections; excessive exercise; and so on. Hypothyroidism is a clinical setting in which thyroid hormones are produced and secreted ineffectively.Case Report: In our article, two cases of rhabdomyolysis due to hypothyroidism are presented who got the diagnosis of hypothyroidism but had not gotten any treatment. It was seen that the clinical signs and symptoms of the patients recovered quickly with the beginning of hormone replacement, and muscle enzymes decreased back to normal levels.Conclusion: It should be remembered that depression of the respiratory system, cardiomegaly, pericardial tamponade, angina pectoris, congestive heart failure, and rhabdomyolysis can develop in those patients who are diagnosed with hypothyroidism and yet not treated properly

Keywords

Hypothyroidism , rhabdomyolysis

References

• Melli G, Chaudhry V, Cornblath DR. Rhabdomyolysis: an evaluation of 475 hospitalized patients. Medicine (Baltimore) 2005; 84: 377-85. [CrossRef]
• Demester N. Diseases of the thyroid. Clinician Reviews 2001; 11: 58-64.
• Goldman J, Matz R, Mortimer R, Freeman R. High elevations of creatine phosphokinaze in hypothyroidism. JAMA1977; 325-6. [CrossRef]
• Yarman S, Cikim A, Kurtulmus N. Hipotiroidik Hastalarda Kreatin Fosfokinaz yüksekliği. İst Tıp Fak. Mecmuası 2002; 65: 4.
• Giampietro O, Clerico A, Buzzigoli G, Del Chicca MG, Boni C, Carpi A. Detection of hypothyroid myopathy by measurement of Vvarious serum muscle markers - myoglobin, creatine kinase, lactate dehydrogenase and their isoenzymes. Correlations with thyroid hormone levels (free and total) and clinical usefulness. Horm Res 1984; 19: 232-42. [CrossRef]
• Beyer IW, Karmali R, Demeester-Mirkine N, Cogan E, Fuss MJ. Serum creatine kinase levels in overt and subclinical hypothyroidism. Thyroid1998; 8: 1029-31. [CrossRef]
• Unal A, Sipahioglu MH, Tokgoz B, Akcakaya M, Coskun R, Oymak O, Utas C. Antihiperlipidemik Tedavi Sonrası Gelişen Rabdomiyoliz: Üç Olgu Sunumu. Erciyes Tıp Dergisi (Erciyes Medical Journal) 2009; 1: 1-4.
• Rosenson RS. Current overview of statin induced myopathy. Am J Med 2004; 116: 408-16. [CrossRef]