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Deli Bal Zehirlenmesi; Olgu Sunumu

Year 2010, Volume: 1 Issue: 2, 33 - 36, 01.04.2010

Abstract

İçerisinde grayanotoksin bulunduran Rhododendron familyası bitkilerinden
beslenen arıların ürettiği bal, ülkemizde halk arasında deli bal, tutar bal veya
acı bal olarak bilinir. Bu balın yenilmesi sonrasında doza bağımlı olarak
insanlarda hafif sindirim sistemi irritasyon bulgularından, yaşamı tehdit
edebilen bradiaritmiler, hipotansiyon ve santral sinir sistemi etkilenimine
kadar birçok semptoma sebep olabilir. Biz bu yazıda acil servise baş dönmesi
ve halsizlik şikayetiyle baş vuran hastanın çekilen elektrokardiyografisinde
Mobitz tip 1 blok saptadıktan sonra öykünün derinleştirilmesiyle bu
semptomlar oluşmadan yaklaşık 1 saat önce bal yediği öğrenilen bir olguyu
tartıştık.

References

  • Milne RI, Abbott RJ. Origin and evolution of invasive naturalized material of Rhododendron ponticum L. in the British isles. Mol Ecol. 2000;9:541-56.
  • Başgül A. Deli bal zehirlenmesi. Yoğun Bakım Dergisi 2003;3:33-6
  • Yilmaz O, Eser M, Sahiner A, Altintop L, Yesildag O. Hypotension, bradycardia and syncope caused by honey poisoning. Resuscitation 2006;68:405-8.
  • Brown BS, Akera T, Brody TM. Mechanism of grayanotoxin III-induced after potentials in feline cardiac purkinje fibers. Eur J Pharmacol. 1981;754:271-81.
  • Leach DG. Ancient curse of the rhododendron. Am Horticulturist. 1972;51:20-29.
  • Koçak S, Uçar K, Gül M. Deli bal zehirlenmesi. Genel Tıp Dergisi 2008;18:137-8.
  • Kurtoğlu S. Zehirlenmeler, Teşhis ve Tedavi. Kayseri: Erciyes Ünv. Yayınları, No:30, 1992:569-70.
  • Seyamal I, Yamaoka K, Yakehiro M, Yoshioka Y, Morihara K. Is the site of action of grayanotoxin the sodium channel gating of squid axon? Jpn J Physiol 1985; 35: 401-10.
  • Viccellio P. Systemic poisonous plant intoxication. Handbook of Medical Toxicology. Washington: Library of Congress Cataloging, 1993:p.718.
  • Sutlupinar N, Mat A, Satganoglu Y. Poisoning by toxic honey in Turkey. Arch Toxicol. 1993;67:148-50.
  • Von Malottki K, Wiechmann HW. Acute lifethreatening bradycardia: Food poisoning by Turkish wild honey. Dtsch Med Wochenschr. 1996;121:936-8.
  • Onat FY, Yegen BC, Lawrence R, Oktay A, Oktay S. Mad honey poisoning in man and rat. Rev Environ Health. 1991;9:3-9.
  • Biberoğlu S, Biberoğlu K, Komsuoğlu B. Mad honey. JAMA 1988;259:1943.
  • Gündüz A, Tatlı O, Turedi S. Mad honey poisoning from the past to the present Turk J Emerg Med. 2008;8:46-49.
  • Aşçıoğlu M, Özesmi Ç, Doğan P, Özturk F. Effects of acute Grayanotoxin-I administration on nepatic and renal functions in rats. Turk J Med Sci. 2000;30:23-7.
  • Cetin N.G, Marcıl E, Kıldıran M, Ogüt S. Hepatotoxicity with mad honey Turk J Emerg Med. 2009;9:84-86.
  • Dökmeci İ. Gıda Zehirlenmeleri. Toksikoloji/ Zehirlenmelerde Tanı ve Tedavi. İstanbul: Nobel Tıp Kitabevi, 2001:563.
  • Akpir K, Dilmener M. İlaç, Besin ve Gaz Zehirlenmesi. İTF Yayını, 1984.
  • Köseoğlu Z, Kösenli O. Güney Bölgesinde Kuzeyli Bir Toksin: Deli Bal Zehirlenmesi. Akademik Acil Tıp Dergisi 2009;8(1)57-59.
  • Kebler LF. Poisonous honey. Am Pharm Assoc Proc 1896;44:167-74.

Mad Honey Poisoning; A Case Report

Year 2010, Volume: 1 Issue: 2, 33 - 36, 01.04.2010

Abstract

The honey which is produced by the bees, which feed whith the rhododendron
family plants that include grayanotoksin is known as mad honey, wad honey
or bitter honey in our country. Eating this honey dose dependently can cause
a wide spectrum of symptoms, from non specific gastrointestinal symptoms
to life threatening bradyarrhythmias, hypotension and central nervous
system effects. In this case we discussed a patient who admitted emergency
service with dizziness and had Mobitz type 1 block in electrocardiography
after more detailed anamnesis and we discovered that our patient had eaten
mad honey just one hour before the beginning of the symptoms.

References

  • Milne RI, Abbott RJ. Origin and evolution of invasive naturalized material of Rhododendron ponticum L. in the British isles. Mol Ecol. 2000;9:541-56.
  • Başgül A. Deli bal zehirlenmesi. Yoğun Bakım Dergisi 2003;3:33-6
  • Yilmaz O, Eser M, Sahiner A, Altintop L, Yesildag O. Hypotension, bradycardia and syncope caused by honey poisoning. Resuscitation 2006;68:405-8.
  • Brown BS, Akera T, Brody TM. Mechanism of grayanotoxin III-induced after potentials in feline cardiac purkinje fibers. Eur J Pharmacol. 1981;754:271-81.
  • Leach DG. Ancient curse of the rhododendron. Am Horticulturist. 1972;51:20-29.
  • Koçak S, Uçar K, Gül M. Deli bal zehirlenmesi. Genel Tıp Dergisi 2008;18:137-8.
  • Kurtoğlu S. Zehirlenmeler, Teşhis ve Tedavi. Kayseri: Erciyes Ünv. Yayınları, No:30, 1992:569-70.
  • Seyamal I, Yamaoka K, Yakehiro M, Yoshioka Y, Morihara K. Is the site of action of grayanotoxin the sodium channel gating of squid axon? Jpn J Physiol 1985; 35: 401-10.
  • Viccellio P. Systemic poisonous plant intoxication. Handbook of Medical Toxicology. Washington: Library of Congress Cataloging, 1993:p.718.
  • Sutlupinar N, Mat A, Satganoglu Y. Poisoning by toxic honey in Turkey. Arch Toxicol. 1993;67:148-50.
  • Von Malottki K, Wiechmann HW. Acute lifethreatening bradycardia: Food poisoning by Turkish wild honey. Dtsch Med Wochenschr. 1996;121:936-8.
  • Onat FY, Yegen BC, Lawrence R, Oktay A, Oktay S. Mad honey poisoning in man and rat. Rev Environ Health. 1991;9:3-9.
  • Biberoğlu S, Biberoğlu K, Komsuoğlu B. Mad honey. JAMA 1988;259:1943.
  • Gündüz A, Tatlı O, Turedi S. Mad honey poisoning from the past to the present Turk J Emerg Med. 2008;8:46-49.
  • Aşçıoğlu M, Özesmi Ç, Doğan P, Özturk F. Effects of acute Grayanotoxin-I administration on nepatic and renal functions in rats. Turk J Med Sci. 2000;30:23-7.
  • Cetin N.G, Marcıl E, Kıldıran M, Ogüt S. Hepatotoxicity with mad honey Turk J Emerg Med. 2009;9:84-86.
  • Dökmeci İ. Gıda Zehirlenmeleri. Toksikoloji/ Zehirlenmelerde Tanı ve Tedavi. İstanbul: Nobel Tıp Kitabevi, 2001:563.
  • Akpir K, Dilmener M. İlaç, Besin ve Gaz Zehirlenmesi. İTF Yayını, 1984.
  • Köseoğlu Z, Kösenli O. Güney Bölgesinde Kuzeyli Bir Toksin: Deli Bal Zehirlenmesi. Akademik Acil Tıp Dergisi 2009;8(1)57-59.
  • Kebler LF. Poisonous honey. Am Pharm Assoc Proc 1896;44:167-74.
There are 20 citations in total.

Details

Other ID JA85TH82JF
Journal Section Research Article
Authors

Ferhat İçme

Yunsur Çevik This is me

Publication Date April 1, 2010
Submission Date April 1, 2010
Published in Issue Year 2010 Volume: 1 Issue: 2

Cite

APA İçme, F., & Çevik, Y. (2010). Mad Honey Poisoning; A Case Report. Journal of Emergency Medicine Case Reports, 1(2), 33-36.
AMA İçme F, Çevik Y. Mad Honey Poisoning; A Case Report. Journal of Emergency Medicine Case Reports. April 2010;1(2):33-36.
Chicago İçme, Ferhat, and Yunsur Çevik. “Mad Honey Poisoning; A Case Report”. Journal of Emergency Medicine Case Reports 1, no. 2 (April 2010): 33-36.
EndNote İçme F, Çevik Y (April 1, 2010) Mad Honey Poisoning; A Case Report. Journal of Emergency Medicine Case Reports 1 2 33–36.
IEEE F. İçme and Y. Çevik, “Mad Honey Poisoning; A Case Report”, Journal of Emergency Medicine Case Reports, vol. 1, no. 2, pp. 33–36, 2010.
ISNAD İçme, Ferhat - Çevik, Yunsur. “Mad Honey Poisoning; A Case Report”. Journal of Emergency Medicine Case Reports 1/2 (April 2010), 33-36.
JAMA İçme F, Çevik Y. Mad Honey Poisoning; A Case Report. Journal of Emergency Medicine Case Reports. 2010;1:33–36.
MLA İçme, Ferhat and Yunsur Çevik. “Mad Honey Poisoning; A Case Report”. Journal of Emergency Medicine Case Reports, vol. 1, no. 2, 2010, pp. 33-36.
Vancouver İçme F, Çevik Y. Mad Honey Poisoning; A Case Report. Journal of Emergency Medicine Case Reports. 2010;1(2):33-6.