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Olanzapin Kullanımına Bağlı Derin Ven Trombozu

Year 2011, Volume: 2 Issue: 4, 30 - 32, 01.10.2011

Sinan Genç Cuma Yıldırım Pınar Yarbil Hasan Kılıç Behçet Al

Abstract

Atipik antipsikotik ilaçlar ekstrapramidal yan etki oluşturma
riskleri düşük olduğu için başta şizofreni ve manide giderek artan
oranlarda kullanılmaktadır. Atipik antipsikotik ilaç kullanımında
başta obezite ve dislipidemi gibi birçok metabolik yan etki
oluşabilmektedir. Atipik antipsikotik ilaç kullanımı ve venöz
tromboemboli gelişimi arasında ilişki olabileceğini gösteren
çalışmaların sayısı giderek artmaktadır. Acil servisimize bacakta
ağrı ve şişlik sebebiyle başvuran ve bipolar bozukluk nedeniyle
olanzapin kulllanan 33 yaşında erkek hastada derin ven trombozu
saptadık. Biz bu olgu sunumunda venöz tromboemboli gelişimi
için risk faktörlerinin olmadığı hastada olanzapine kullanımının
derin ven trombozuna yol açabileceğini tartıştık.

Keywords

Olanzapin derin ven trombozu

References

  • Tomassen R, Vandenbroucke JP, Rosendal FR. Antipsychotic Medication and Venous Thrombosis. British Journal of Psychiatry. 2001;179:63-66.
  • Jonsson A, Horvath-Puho E, Hagg S, Pedersen L, Sorensen HT. Antipsychotics and Risk of Venous Thromboembolism: A population- Based Case- Control Study. Clinical Epidemiology 2009;1:19-26.
  • Goldhaber SZ, Visani L, De Rosa M. Acute pulmonary embolism: Clinical Outcomes in the International Cooperative Pulmonary Em- bolism Registry (ICOPER). Lancet 1999;353 (9162):1386-1389.
  • Anderson FA Jr, Spencer FA. Risk Factors for Venous Thrombo- embolism. Circulation. 2003;107: 9-16.
  • Van Neste E, Verbruggen W, Leysen M. Deep Venous Thrombosis and Pulmonary Embolism in Psychiatric Settings. European Jour- nal of Psychiatry. 2009;23(1):19-30.
  • Yeh J, Lee A. Clozapine-Induced Pulmonary Embolism: A Case Re- port and Literature Review. Hospital Pharmacy. 2009;44(1):36-40.
  • Hagg S, Bate A, Stahl M, Spigset O. Associations Between Ve- nous Thromboembolism and Antipsychotics. Drug Safety. 2008;31(8):685-694.
  • Maempel JFZ, Darmanin G, Naeem K, Patel M. Olanzapine and Pulmonary Embolism, A Rare Association: A Case Report. Cases Journal 2010;3:36.
  • Kannan R, Molina DK. Olanzapine: A New Risk Factor for Pul- monary Embolus?. American Journal of Forensic Medicine and Pathology. 2008;29(4):368-370.
  • Liperoti R, Pedone C, Lapane KL, Mor V. Venous Thromboem- bolism Among Elderly Patients Treated with Atypical and Con- ventional Antipsychotic Agents. Archives of Internal Medicine. 2005;165:2677-2682.

Olanzapine Induced Deep Venous Thrombosis

Year 2011, Volume: 2 Issue: 4, 30 - 32, 01.10.2011

Sinan Genç Cuma Yıldırım Pınar Yarbil Hasan Kılıç Behçet Al

Abstract

Cause of a lower risk of extrapyramidal side effects atypical antipsychotic drugs are primarily being used more frequently in schizophrenia and mania. Many metabolic side effects particularly such as obesity and dyslipidemia may occur in the use of atypical antipsychotic drugs. Numbers of studies that show a relationship between atypical antipsychotic use and the development of venous thromboembolism have been increasing. We discovered deep venous thrombosis in 33year- old male patient, who had been using olanzapine due to bipolar disorder, admitted to our emergency service with leg pain and swelling. In this case report we discussed that in a patient without risk factors for developing venous thromboembolism, the use of olanzapine may lead to deep venous thrombosis

Keywords

Olanzapine deep venous thrombosis

References

  • Tomassen R, Vandenbroucke JP, Rosendal FR. Antipsychotic Medication and Venous Thrombosis. British Journal of Psychiatry. 2001;179:63-66.
  • Jonsson A, Horvath-Puho E, Hagg S, Pedersen L, Sorensen HT. Antipsychotics and Risk of Venous Thromboembolism: A population- Based Case- Control Study. Clinical Epidemiology 2009;1:19-26.
  • Goldhaber SZ, Visani L, De Rosa M. Acute pulmonary embolism: Clinical Outcomes in the International Cooperative Pulmonary Em- bolism Registry (ICOPER). Lancet 1999;353 (9162):1386-1389.
  • Anderson FA Jr, Spencer FA. Risk Factors for Venous Thrombo- embolism. Circulation. 2003;107: 9-16.
  • Van Neste E, Verbruggen W, Leysen M. Deep Venous Thrombosis and Pulmonary Embolism in Psychiatric Settings. European Jour- nal of Psychiatry. 2009;23(1):19-30.
  • Yeh J, Lee A. Clozapine-Induced Pulmonary Embolism: A Case Re- port and Literature Review. Hospital Pharmacy. 2009;44(1):36-40.
  • Hagg S, Bate A, Stahl M, Spigset O. Associations Between Ve- nous Thromboembolism and Antipsychotics. Drug Safety. 2008;31(8):685-694.
  • Maempel JFZ, Darmanin G, Naeem K, Patel M. Olanzapine and Pulmonary Embolism, A Rare Association: A Case Report. Cases Journal 2010;3:36.
  • Kannan R, Molina DK. Olanzapine: A New Risk Factor for Pul- monary Embolus?. American Journal of Forensic Medicine and Pathology. 2008;29(4):368-370.
  • Liperoti R, Pedone C, Lapane KL, Mor V. Venous Thromboem- bolism Among Elderly Patients Treated with Atypical and Con- ventional Antipsychotic Agents. Archives of Internal Medicine. 2005;165:2677-2682.
There are 10 citations in total.

Details

Other ID JA83ND83AY
Journal Section Research Article
Authors

Sinan Genç

Cuma Yıldırım This is me

Pınar Yarbil This is me

Hasan Kılıç This is me

Behçet Al This is me

Publication Date October 1, 2011
Submission Date October 1, 2011
Published in Issue Year 2011 Volume: 2 Issue: 4

Cite

APA Genç, S., Yıldırım, C., Yarbil, P., Kılıç, H., et al. (2011). Olanzapine Induced Deep Venous Thrombosis. Journal of Emergency Medicine Case Reports, 2(4), 30-32.
AMA Genç S, Yıldırım C, Yarbil P, Kılıç H, Al B. Olanzapine Induced Deep Venous Thrombosis. Journal of Emergency Medicine Case Reports. October 2011;2(4):30-32.
Chicago Genç, Sinan, Cuma Yıldırım, Pınar Yarbil, Hasan Kılıç, and Behçet Al. “Olanzapine Induced Deep Venous Thrombosis”. Journal of Emergency Medicine Case Reports 2, no. 4 (October 2011): 30-32.
EndNote Genç S, Yıldırım C, Yarbil P, Kılıç H, Al B (October 1, 2011) Olanzapine Induced Deep Venous Thrombosis. Journal of Emergency Medicine Case Reports 2 4 30–32.
IEEE S. Genç, C. Yıldırım, P. Yarbil, H. Kılıç, and B. Al, “Olanzapine Induced Deep Venous Thrombosis”, Journal of Emergency Medicine Case Reports, vol. 2, no. 4, pp. 30–32, 2011.
ISNAD Genç, Sinan et al. “Olanzapine Induced Deep Venous Thrombosis”. Journal of Emergency Medicine Case Reports 2/4 (October 2011), 30-32.
JAMA Genç S, Yıldırım C, Yarbil P, Kılıç H, Al B. Olanzapine Induced Deep Venous Thrombosis. Journal of Emergency Medicine Case Reports. 2011;2:30–32.
MLA Genç, Sinan et al. “Olanzapine Induced Deep Venous Thrombosis”. Journal of Emergency Medicine Case Reports, vol. 2, no. 4, 2011, pp. 30-32.
Vancouver Genç S, Yıldırım C, Yarbil P, Kılıç H, Al B. Olanzapine Induced Deep Venous Thrombosis. Journal of Emergency Medicine Case Reports. 2011;2(4):30-2.