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Antipsikotik İlaçların Ciddi Bir Yan Etkisi: Nöroleptik Malign Sendrom

Year 2012, Volume: 3 Issue: 3, 83 - 85, 01.07.2012

Mehmet Ergin Başar Cander Sadık Girişgin Sedat Koçak Tarık Acar Mehmet Gül

Abstract

Nöroleptik Malign Sendrom (NMS) dopamin reseptör antagonistleri ile tedavinin nadir, idiosenkratik, potansiyel olarak hayatı
tehdit edici bir komplikasyonudur. NMS ateş, ciddi kas rijiditesi
ve otonomik ve mental durum değişiklikleri karakterizedir. Bu yazıda Ocak 2010 ve Nisan 2011 tarihleri arasında acil servisimize
başvurmuş ve NMS tanısı almış 3 olgu sunulmaktadır. NMS akut
başlangıç, hipertermi, belirgin mental değişiklik, artmış motor
aktivite ve otonomik semptomlar ile ortaya çıkar. Agresif ve zamanında yapılan girişimler fatal sonuç potansiyeli açısından çok
önemlidir. Kullanılan ajanın hemen kesilmesini takiben destekleyici tedavi çoğu olguda tercih edilen tedavi seçeneğidir. Destek
tedavi, intravenöz sıvılar ile hidrasyonun sağlanması ve irritasyon
için benzodiazepinlerin kullanımını içerir.

Keywords

Antipsikotikler yan etki nöroleptik malign sendrom

References

  • Strawn JR, Keck PE, Caroff SN. Neuroleptic malignant syndrome. Am J Psychiatry 2007; 164: 870-6. [CrossRef]
  • Cvjetkovic-Bosnjak M, Sodatovic-Stajic B. Side effects of antipschycotic agents- neuroleptic malignant syndrome. Med Pregl 2010; 63: 705-8. [CrossRef]
  • Steele D, Keltner NL, McGuiness TM. Are neuroleptic malignant syndro- me and serotonin syndrome the same syndrome? Perspect Psychiatr Care 2010; 47: 58-62. [CrossRef]
  • Sato Y, Asoh T, Metoki N, Satoh K. Efficiancy of methylprednisolone pul- se therapy on neuroleptic malignant syndrome in Parkinson’s disease. J Neurol Neurosurg Psychiatry 2003; 74: 574-6. [CrossRef]
  • Man SP. An uncommon adverse efect of levodopa withdrawal in a patient taking antipsychotic medication: neuroleptic malignant-like syndrome. Hong Kong Med J 2011; 17: 74-6.
  • Pereira YD, Srivastava A, Cuncoliencar BS, Naik N. Resolution of symptoms in neuroleptic malignant syndrome. Indian J Psychiatry 2010; 52: 264-6. [CrossRef]
  • Levenson J. Neuroleptic malign syndrome. Am J Pscyhiatry 1985; 142: 1137-45.
  • American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th ed, text revision. Washington DC, American Psychiatric Association, 2000, pp. 795-8.

A Serious Side Effect of Antipsychotic Therapy: Neuroleptic Malign Syndrome

Year 2012, Volume: 3 Issue: 3, 83 - 85, 01.07.2012

Mehmet Ergin Başar Cander Sadık Girişgin Sedat Koçak Tarık Acar Mehmet Gül

Abstract

Neuroleptic malign syndrome (NMS) is a rare, idiosyncratic, potentially life-threatening complication of treatment with dopamine receptor antagonists. NMS is characterized by fever, severe muscle rigidity and autonomic and mental status changes. Here, we present three NMS cases admitted to our emergency service between January 2010 and April 2011. NMS has the characteristics of acute onset, hyperthermia, profound mental changes, heightened motor activity and autonomic symptoms. Aggressive and timely intervention is crucial due to the potential for fatal outcomes. Immediate withdrawal of the offending agent followed by supportive care is the treatment of choice for most patients. Supportive care includes the infusion of intravenous fluids for hydration and treatment with benzodiazepines to manage irritation

Keywords

Antipsychotics adverse effect neuroleptic malign syndrome

References

  • Strawn JR, Keck PE, Caroff SN. Neuroleptic malignant syndrome. Am J Psychiatry 2007; 164: 870-6. [CrossRef]
  • Cvjetkovic-Bosnjak M, Sodatovic-Stajic B. Side effects of antipschycotic agents- neuroleptic malignant syndrome. Med Pregl 2010; 63: 705-8. [CrossRef]
  • Steele D, Keltner NL, McGuiness TM. Are neuroleptic malignant syndro- me and serotonin syndrome the same syndrome? Perspect Psychiatr Care 2010; 47: 58-62. [CrossRef]
  • Sato Y, Asoh T, Metoki N, Satoh K. Efficiancy of methylprednisolone pul- se therapy on neuroleptic malignant syndrome in Parkinson’s disease. J Neurol Neurosurg Psychiatry 2003; 74: 574-6. [CrossRef]
  • Man SP. An uncommon adverse efect of levodopa withdrawal in a patient taking antipsychotic medication: neuroleptic malignant-like syndrome. Hong Kong Med J 2011; 17: 74-6.
  • Pereira YD, Srivastava A, Cuncoliencar BS, Naik N. Resolution of symptoms in neuroleptic malignant syndrome. Indian J Psychiatry 2010; 52: 264-6. [CrossRef]
  • Levenson J. Neuroleptic malign syndrome. Am J Pscyhiatry 1985; 142: 1137-45.
  • American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th ed, text revision. Washington DC, American Psychiatric Association, 2000, pp. 795-8.
There are 8 citations in total.

Details

Other ID JA58UJ82AM
Journal Section Case Report
Authors

Mehmet Ergin This is me

Başar Cander This is me

Sadık Girişgin This is me

Sedat Koçak This is me

Tarık Acar This is me

Mehmet Gül This is me

Publication Date July 1, 2012
Submission Date July 1, 2012
Published in Issue Year 2012 Volume: 3 Issue: 3

Cite

APA Ergin, M., Cander, B., Girişgin, S., Koçak, S., et al. (2012). A Serious Side Effect of Antipsychotic Therapy: Neuroleptic Malign Syndrome. Journal of Emergency Medicine Case Reports, 3(3), 83-85.
AMA Ergin M, Cander B, Girişgin S, Koçak S, Acar T, Gül M. A Serious Side Effect of Antipsychotic Therapy: Neuroleptic Malign Syndrome. Journal of Emergency Medicine Case Reports. July 2012;3(3):83-85.
Chicago Ergin, Mehmet, Başar Cander, Sadık Girişgin, Sedat Koçak, Tarık Acar, and Mehmet Gül. “A Serious Side Effect of Antipsychotic Therapy: Neuroleptic Malign Syndrome”. Journal of Emergency Medicine Case Reports 3, no. 3 (July 2012): 83-85.
EndNote Ergin M, Cander B, Girişgin S, Koçak S, Acar T, Gül M (July 1, 2012) A Serious Side Effect of Antipsychotic Therapy: Neuroleptic Malign Syndrome. Journal of Emergency Medicine Case Reports 3 3 83–85.
IEEE M. Ergin, B. Cander, S. Girişgin, S. Koçak, T. Acar, and M. Gül, “A Serious Side Effect of Antipsychotic Therapy: Neuroleptic Malign Syndrome”, Journal of Emergency Medicine Case Reports, vol. 3, no. 3, pp. 83–85, 2012.
ISNAD Ergin, Mehmet et al. “A Serious Side Effect of Antipsychotic Therapy: Neuroleptic Malign Syndrome”. Journal of Emergency Medicine Case Reports 3/3 (July 2012), 83-85.
JAMA Ergin M, Cander B, Girişgin S, Koçak S, Acar T, Gül M. A Serious Side Effect of Antipsychotic Therapy: Neuroleptic Malign Syndrome. Journal of Emergency Medicine Case Reports. 2012;3:83–85.
MLA Ergin, Mehmet et al. “A Serious Side Effect of Antipsychotic Therapy: Neuroleptic Malign Syndrome”. Journal of Emergency Medicine Case Reports, vol. 3, no. 3, 2012, pp. 83-85.
Vancouver Ergin M, Cander B, Girişgin S, Koçak S, Acar T, Gül M. A Serious Side Effect of Antipsychotic Therapy: Neuroleptic Malign Syndrome. Journal of Emergency Medicine Case Reports. 2012;3(3):83-5.