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Hiperalbüminemi ve Birlikteliğindeki Hiperkalsemi Klinisyeni Nasıl Yönlendirmeli? Olgu Sunumu ve Derleme

Year 2014, Volume: 5 Issue: 5, 148 - 150, 01.05.2014

Abstract

Giriş: Hiperalbuminemi ve birlikteliğindeki hiperkalsemi oldukça
nadir karşılaşılan bir klinik durumdur. En sık laboratuar hatası olarak
karşımıza çıkmasına rağmen literatürde dehidratasyona bağlı
albümin/globülin oranı değişmeden, rölatif hiperproteinemi ile
beraber görülebildiği bildirilmiştir.
Olgu Sunumu: Biz bu yazıda; 1 haftadır giderek artan halsizlik ve
bulantı şikâyetleri ile acil servise başvuran ve hiperalbuminemisi,
hiperkalsemisi tespit edilen 20 yaşında erkek hastayı sunduk,
literatürü inceledik.
Sonuç: Bulantı ve halsizlik gibi spesifik olmayan şikayetler
ile acil servise başvuran hastalarda, herhangi bir sebep
gösterilemediğinde albümin yüksekliği ve hiperkalsemi varlığı
açısından da araştırılması gerekmektedir.

References

  • Farrugia A. Albumin usage in clinical medicine: tradition or therapeutic? Transfus Med Rev 2010; 24: 53-3. [CrossRef]
  • Feldman M, Soni N, Dickson B. Influence of hypoalbuminemia or hyperalbuminemia on the serum anion gap. J Lab Clin Med 2005; 146: 317-20. [CrossRef]
  • Sugio S, Kashima A, Mochizuki S, Noda M, Kobayashi K. Crystal structure of human serum albumin at 2.5 A resolution. Protein Eng 1999; 12: 439-46. [CrossRef]
  • Cooper ES, Wellman ML, Carsillo ME. Hyperalbuminemia associated with hepatocellular carcinoma in a dog. Vet Clin Pathol 2009; 38: 516-20. [CrossRef]
  • Koltun M, Comper WD. Retention of albumin in the circulation is governed by saturable renal cell-mediated processes. Microcirculation 2004; 11: 351-60. [CrossRef]
  • Rossing TH, Maffeo N, Fencl V. Acid-base effects of altering plasma protein concentration in human blood in vitro. J Appl Physiol (1985). 1986; 61: 2260-5.
  • Hatherill M, Waggie Z, Purves L, Reynolds L, Argent A. Correction of the anion gap for albumin in order to detect occult tissue anions in shock. Arch Dis Child 2002; 87: 526-9. [CrossRef]
  • Carvounis CP, Feinfeld DA. A simple estimate of the effect of the serum albumin level on the anion Gap. Am J Nephrol 2000; 20: 369-72. [CrossRef]
  • Mutlu EA, Keshavarzian A, Mutlu GM. Hyperalbuminemia and elevated transaminases associated with high-protein diet. Scand J Gastroenterol 2006; 41: 759-60. [CrossRef]
  • Häussinger D, Gerok W, Roth E, Lang F. Cellular hydration state: an important determinant of protein catabolism in health and disease. The Lancet 1993; 22; 341: 1330-2. [CrossRef]
  • JAEMCR 2014; 5: 148-50
  • Coşkun et al. Hyperalbuminemia and Associated Hypercalcemia

How Does the Clinician Lay Out Hyperalbuminemia and Associated Hypercalcemia? Case Report and Review

Year 2014, Volume: 5 Issue: 5, 148 - 150, 01.05.2014

Abstract

Introduction: Hyperalbuminemia and associated hypercalcemia is an extremely rare clinical condition. Although it is most commonly encountered as a laboratory error, in the literature, it has been reported to be due to dehydration, depending on relative hyperproteinemia with unchanged albumin/globulin ratio.Case Report: In this manuscript, we reported a 20-year-old male who was admitted to the emergency department with the complaints of progressive fatigue and nausea for 1 week due to hyperalbuminemia and hypercalcemia and reviewed the literature.Conclusion: In the patients who are admitted to emergency departments with nonspecific complaints, like fatigue and nausea, if the cause of the complaints cannot be shown, hyperalbuminemia and hypercalcemia should be investigated

References

  • Farrugia A. Albumin usage in clinical medicine: tradition or therapeutic? Transfus Med Rev 2010; 24: 53-3. [CrossRef]
  • Feldman M, Soni N, Dickson B. Influence of hypoalbuminemia or hyperalbuminemia on the serum anion gap. J Lab Clin Med 2005; 146: 317-20. [CrossRef]
  • Sugio S, Kashima A, Mochizuki S, Noda M, Kobayashi K. Crystal structure of human serum albumin at 2.5 A resolution. Protein Eng 1999; 12: 439-46. [CrossRef]
  • Cooper ES, Wellman ML, Carsillo ME. Hyperalbuminemia associated with hepatocellular carcinoma in a dog. Vet Clin Pathol 2009; 38: 516-20. [CrossRef]
  • Koltun M, Comper WD. Retention of albumin in the circulation is governed by saturable renal cell-mediated processes. Microcirculation 2004; 11: 351-60. [CrossRef]
  • Rossing TH, Maffeo N, Fencl V. Acid-base effects of altering plasma protein concentration in human blood in vitro. J Appl Physiol (1985). 1986; 61: 2260-5.
  • Hatherill M, Waggie Z, Purves L, Reynolds L, Argent A. Correction of the anion gap for albumin in order to detect occult tissue anions in shock. Arch Dis Child 2002; 87: 526-9. [CrossRef]
  • Carvounis CP, Feinfeld DA. A simple estimate of the effect of the serum albumin level on the anion Gap. Am J Nephrol 2000; 20: 369-72. [CrossRef]
  • Mutlu EA, Keshavarzian A, Mutlu GM. Hyperalbuminemia and elevated transaminases associated with high-protein diet. Scand J Gastroenterol 2006; 41: 759-60. [CrossRef]
  • Häussinger D, Gerok W, Roth E, Lang F. Cellular hydration state: an important determinant of protein catabolism in health and disease. The Lancet 1993; 22; 341: 1330-2. [CrossRef]
  • JAEMCR 2014; 5: 148-50
  • Coşkun et al. Hyperalbuminemia and Associated Hypercalcemia
There are 12 citations in total.

Details

Other ID JA36FV57ED
Journal Section Case Report
Authors

Selçuk Coşkun

Yücel Yüzbaşıoğlu This is me

Havva Şahin Kavaklı This is me

Alp Sener This is me

Ferhat Icme This is me

Erkut Erol This is me

Publication Date May 1, 2014
Submission Date May 1, 2014
Published in Issue Year 2014 Volume: 5 Issue: 5

Cite

APA Coşkun, S., Yüzbaşıoğlu, Y., Kavaklı, H. Ş., Sener, A., et al. (2014). How Does the Clinician Lay Out Hyperalbuminemia and Associated Hypercalcemia? Case Report and Review. Journal of Emergency Medicine Case Reports, 5(5), 148-150.
AMA Coşkun S, Yüzbaşıoğlu Y, Kavaklı HŞ, Sener A, Icme F, Erol E. How Does the Clinician Lay Out Hyperalbuminemia and Associated Hypercalcemia? Case Report and Review. Journal of Emergency Medicine Case Reports. May 2014;5(5):148-150.
Chicago Coşkun, Selçuk, Yücel Yüzbaşıoğlu, Havva Şahin Kavaklı, Alp Sener, Ferhat Icme, and Erkut Erol. “How Does the Clinician Lay Out Hyperalbuminemia and Associated Hypercalcemia? Case Report and Review”. Journal of Emergency Medicine Case Reports 5, no. 5 (May 2014): 148-50.
EndNote Coşkun S, Yüzbaşıoğlu Y, Kavaklı HŞ, Sener A, Icme F, Erol E (May 1, 2014) How Does the Clinician Lay Out Hyperalbuminemia and Associated Hypercalcemia? Case Report and Review. Journal of Emergency Medicine Case Reports 5 5 148–150.
IEEE S. Coşkun, Y. Yüzbaşıoğlu, H. Ş. Kavaklı, A. Sener, F. Icme, and E. Erol, “How Does the Clinician Lay Out Hyperalbuminemia and Associated Hypercalcemia? Case Report and Review”, Journal of Emergency Medicine Case Reports, vol. 5, no. 5, pp. 148–150, 2014.
ISNAD Coşkun, Selçuk et al. “How Does the Clinician Lay Out Hyperalbuminemia and Associated Hypercalcemia? Case Report and Review”. Journal of Emergency Medicine Case Reports 5/5 (May 2014), 148-150.
JAMA Coşkun S, Yüzbaşıoğlu Y, Kavaklı HŞ, Sener A, Icme F, Erol E. How Does the Clinician Lay Out Hyperalbuminemia and Associated Hypercalcemia? Case Report and Review. Journal of Emergency Medicine Case Reports. 2014;5:148–150.
MLA Coşkun, Selçuk et al. “How Does the Clinician Lay Out Hyperalbuminemia and Associated Hypercalcemia? Case Report and Review”. Journal of Emergency Medicine Case Reports, vol. 5, no. 5, 2014, pp. 148-50.
Vancouver Coşkun S, Yüzbaşıoğlu Y, Kavaklı HŞ, Sener A, Icme F, Erol E. How Does the Clinician Lay Out Hyperalbuminemia and Associated Hypercalcemia? Case Report and Review. Journal of Emergency Medicine Case Reports. 2014;5(5):148-50.