Case Report
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Year 2023, Volume: 14 Issue: 2, 44 - 45, 07.07.2023
https://doi.org/10.33706/jemcr.1294738

Abstract

References

  • Çakmak F. Demographic Characteristics of Patients Applied to The Emergency Service with Drug Intoxications. Eurasian Journal of Toxicology. 2020; 2(3): 68-70.
  • Balkan, B. , Demir, G. , Balkan, F. , Çetingök, H. &Atiç, E. (2020). Metformin İlişkili Laktik Asidoz; Bir Olgu Nedeni İle Literatürün Gözden Geçirilmesi. Tıp Fakültesi Klinikleri Dergisi. 3 (1) , 49-53 .
  • Çağla Patır, D. , Köseli, İ. , Engin, B. & Akar, H. (2019). Metformin intoksikasyonuna bağlı gelişen nadir bir birliktelik şiddetli laktik asidoz ve akut pankreatit: Olgu sunumu . İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi , 4 (4) , 197-199 .
  • Aydar, H. , Tezcan, N. & Mutluay, R. (2022). Metformin intoksikasyonuna sekonder gelişen akut böbrek hasarı ve laktik asidoz . Pamukkale Medical Journal , 15 (2) , 379-382 . DOI: 10.31362/patd.900939
  • Eren, E. , Türe, M. , Almaz, V. , Bilgiç, T. , Yıldırım, İ. & Gider, T. (2012). Bir ergende metformin zehirlenmesi . Türk Pediatri Arşivi , 47 (4) , 313-314 . DOI: 10.4274/tpa.1004
  • Çelebi K., Ahmet Ö. Acute Renal Failure Due to Metformin Intoxication: Case Report. J Turk Soc Intensive Care. 2018; 16: 76-78
  • Gedik M. S. , Hakkoymaz H. , Kilci A. İ. , Küçük Ö. F. General Approach to Cases of Drug Intoxication. Eurasian Journal of Critical Care. 2023; 5(1): 17-21.
  • Sener K, Arslan B, Ozselcuk S, Guven R. Resistant Lactic Acidemia Due to Accidental Cheese Starter Culture Ingestion. American Journal of Emergency Medicine. 2022;60: 228.e1-228.e2
  • Wills BK., Bryant SM., Buckley P., Seo B. Can acute over dose of metformin lead to lactic acidosis? Am J EmergMed. 2010; 28: 857-861.
  • Li Cavoli G.,Tortorici C., Bono L., Giammarresi C., Ferrantelli A., Zagarrigo C., et al. Acute kidney injury associated with metformin. Am J EmergMed. 2011; 29: 568-569.
  • Mustafa E., Lai L., Lien YH. Rapid recovery from acute kidney injury in a patient with metformin-associated lactic acidosis and hypothermia. Am J Med. 2012; 125: 1-2.
  • Acquistapace G., Rossi M., Garbi M., Cosci P., Canetta C., Manelli A., et al. Acute metformin intoxication: 2012 experience of Emergency Departement of Lodi, Italy. Clin Chem Lab Med. 2014; 52: 1489-97.

A Case Report of Metformin Related Lactic Acidosis

Year 2023, Volume: 14 Issue: 2, 44 - 45, 07.07.2023
https://doi.org/10.33706/jemcr.1294738

Abstract

Metformin is an oral antidiabetic drug of the biguanide classused in type 2 diabetic patients with normal renal function. The mortality rate is high in cases of lactic acidos is developing in metformin intoxication. In the emergency department, metformin intoxication should be considered in the differential diagnosis of patients whouse metformin and have high anion gap metabolic acidosis (lactic acidosis). The most important and effective treatment with early diagnosis is correction of metabolic acidosis with hemodialysis or hemofiltration methods, bicarbonate treatment, adjustment of blood glucose level. Cardiovascular system support therapy significantly reduces morbidity/mortality. In this case report, we present the early diagnosis and successful treatment of a patient with lactic acidosis due to metformin intoxication.

References

  • Çakmak F. Demographic Characteristics of Patients Applied to The Emergency Service with Drug Intoxications. Eurasian Journal of Toxicology. 2020; 2(3): 68-70.
  • Balkan, B. , Demir, G. , Balkan, F. , Çetingök, H. &Atiç, E. (2020). Metformin İlişkili Laktik Asidoz; Bir Olgu Nedeni İle Literatürün Gözden Geçirilmesi. Tıp Fakültesi Klinikleri Dergisi. 3 (1) , 49-53 .
  • Çağla Patır, D. , Köseli, İ. , Engin, B. & Akar, H. (2019). Metformin intoksikasyonuna bağlı gelişen nadir bir birliktelik şiddetli laktik asidoz ve akut pankreatit: Olgu sunumu . İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi , 4 (4) , 197-199 .
  • Aydar, H. , Tezcan, N. & Mutluay, R. (2022). Metformin intoksikasyonuna sekonder gelişen akut böbrek hasarı ve laktik asidoz . Pamukkale Medical Journal , 15 (2) , 379-382 . DOI: 10.31362/patd.900939
  • Eren, E. , Türe, M. , Almaz, V. , Bilgiç, T. , Yıldırım, İ. & Gider, T. (2012). Bir ergende metformin zehirlenmesi . Türk Pediatri Arşivi , 47 (4) , 313-314 . DOI: 10.4274/tpa.1004
  • Çelebi K., Ahmet Ö. Acute Renal Failure Due to Metformin Intoxication: Case Report. J Turk Soc Intensive Care. 2018; 16: 76-78
  • Gedik M. S. , Hakkoymaz H. , Kilci A. İ. , Küçük Ö. F. General Approach to Cases of Drug Intoxication. Eurasian Journal of Critical Care. 2023; 5(1): 17-21.
  • Sener K, Arslan B, Ozselcuk S, Guven R. Resistant Lactic Acidemia Due to Accidental Cheese Starter Culture Ingestion. American Journal of Emergency Medicine. 2022;60: 228.e1-228.e2
  • Wills BK., Bryant SM., Buckley P., Seo B. Can acute over dose of metformin lead to lactic acidosis? Am J EmergMed. 2010; 28: 857-861.
  • Li Cavoli G.,Tortorici C., Bono L., Giammarresi C., Ferrantelli A., Zagarrigo C., et al. Acute kidney injury associated with metformin. Am J EmergMed. 2011; 29: 568-569.
  • Mustafa E., Lai L., Lien YH. Rapid recovery from acute kidney injury in a patient with metformin-associated lactic acidosis and hypothermia. Am J Med. 2012; 125: 1-2.
  • Acquistapace G., Rossi M., Garbi M., Cosci P., Canetta C., Manelli A., et al. Acute metformin intoxication: 2012 experience of Emergency Departement of Lodi, Italy. Clin Chem Lab Med. 2014; 52: 1489-97.
There are 12 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Case Report
Authors

İlker Akbaş 0000-0001-6676-6517

Caner Akufuk 0000-0003-4624-0803

Muhammet Mustafa Yılmaz 0000-0002-8952-6329

Atilla Eren Kurt 0009-0009-3853-6699

Fatih Coşkun 0000-0003-0541-5910

Publication Date July 7, 2023
Submission Date May 9, 2023
Published in Issue Year 2023 Volume: 14 Issue: 2

Cite

APA Akbaş, İ., Akufuk, C., Yılmaz, M. M., Kurt, A. E., et al. (2023). A Case Report of Metformin Related Lactic Acidosis. Journal of Emergency Medicine Case Reports, 14(2), 44-45. https://doi.org/10.33706/jemcr.1294738
AMA Akbaş İ, Akufuk C, Yılmaz MM, Kurt AE, Coşkun F. A Case Report of Metformin Related Lactic Acidosis. Journal of Emergency Medicine Case Reports. July 2023;14(2):44-45. doi:10.33706/jemcr.1294738
Chicago Akbaş, İlker, Caner Akufuk, Muhammet Mustafa Yılmaz, Atilla Eren Kurt, and Fatih Coşkun. “A Case Report of Metformin Related Lactic Acidosis”. Journal of Emergency Medicine Case Reports 14, no. 2 (July 2023): 44-45. https://doi.org/10.33706/jemcr.1294738.
EndNote Akbaş İ, Akufuk C, Yılmaz MM, Kurt AE, Coşkun F (July 1, 2023) A Case Report of Metformin Related Lactic Acidosis. Journal of Emergency Medicine Case Reports 14 2 44–45.
IEEE İ. Akbaş, C. Akufuk, M. M. Yılmaz, A. E. Kurt, and F. Coşkun, “A Case Report of Metformin Related Lactic Acidosis”, Journal of Emergency Medicine Case Reports, vol. 14, no. 2, pp. 44–45, 2023, doi: 10.33706/jemcr.1294738.
ISNAD Akbaş, İlker et al. “A Case Report of Metformin Related Lactic Acidosis”. Journal of Emergency Medicine Case Reports 14/2 (July 2023), 44-45. https://doi.org/10.33706/jemcr.1294738.
JAMA Akbaş İ, Akufuk C, Yılmaz MM, Kurt AE, Coşkun F. A Case Report of Metformin Related Lactic Acidosis. Journal of Emergency Medicine Case Reports. 2023;14:44–45.
MLA Akbaş, İlker et al. “A Case Report of Metformin Related Lactic Acidosis”. Journal of Emergency Medicine Case Reports, vol. 14, no. 2, 2023, pp. 44-45, doi:10.33706/jemcr.1294738.
Vancouver Akbaş İ, Akufuk C, Yılmaz MM, Kurt AE, Coşkun F. A Case Report of Metformin Related Lactic Acidosis. Journal of Emergency Medicine Case Reports. 2023;14(2):44-5.