Year 2024,
Volume: 15 Issue: 4, 96 - 99, 25.12.2024
Behnaz Niroomand
,
Ibrahim Mohammadzadeh
,
Mitra Rahimi
,
Mohsen Bijandi
References
- 1. Uter W, Stropp G, Schnuch A, Lessmann H. Aniline—A
‘Historical’Contact Allergen? Current Data from the IVDK
and Review of the Literature. The Annals of Occupational
Hygiene. 2007;51(2):219-26.
- 2. Wang Y, Gao H, Na X-L, Dong S-Y, Dong H-W, Yu J, et al. Aniline
induces oxidative stress and apoptosis of primary cultured
hepatocytes. International Journal of Environmental
Research and Public Health. 2016;13(12):1188.
- 3. Acute Exposure Guideline Levels for Selected Airborne
Chemicals: Volume 1. 2000 Available from: https://www.ncbi.
nlm.nih.gov/books/NBK222410/.
- 4. Di Girolamo F, Campanella L, Samperi R, Bachi A. Mass
spectrometric identification of hemoglobin modifications
induced by nitrosobenzene. Ecotoxicology and
Environmental Safety. 2009;72(5):1601-8.
- 5. Harrison J, Jollow D. Contribution of aniline metabolites
to aniline-induced methemoglobinemia. Molecular
pharmacology. 1987;32(3):423-31.
- 6. Fan X, Wang J, Soman KV, Ansari G, Khan MF. Aniline-induced
nitrosative stress in rat spleen: proteomic identification of
nitrated proteins. Toxicology and applied pharmacology.
2011;255(1):103-12.
- 7. Genkin S, Raschewskaja A. The Diagnosis of Chronic
Anilin Poisoning. Zentralblatt fur Gewerbehygiene und
Unfallverhutung. 1933;20:29-36.
- 8. LUBASH GD, PHILLIPS RE, SHIELDS JD, III, BONSNES RW. Acute
Aniline Poisoning Treated By Hemodialysis: Report of a Case.
Archives of Internal Medicine. 1964;114(4):530-2.
- 9. Cannata G, Abate L, Scarabello C, Rubini M, Giacometti A,
Principi N, et al. The Dose Makes the Poison: A Case Report
of Acquired Methemoglobinemia. International Journal of
Environmental Research and Public Health. 2020;17(6):1845.
- 10. Messmer AS, Nickel CH, Bareiss D. <i>P</i>-Chloroaniline
Poisoning Causing Methemoglobinemia: A Case Report
and Review of the Literature. Case Reports in Emergency
Medicine. 2015;2015:208732.
- 11. Wright RO, Lewander WJ, Woolf AD. Methemoglobinemia:
etiology, pharmacology, and clinical management. Ann
Emerg Med. 1999;34(5):646-56.
- 12. Hall AH, Kulig KW, Rumack BH. Drug- and chemical-induced
methaemoglobinaemia. Clinical features and management.
Med Toxicol. 1986;1(4):253-60.
- 13. Bradberry SM, Aw T-C, Williams NR, Vale JA. OCCUPATIONAL
METHAEMOGLOBINAEMIA. Occupational and Environmental
Medicine. 2001;58(9):611-.
- 14. Harvey JW, Keitt AS. Studies of the efficacy and potential
hazards of methylene blue therapy in aniline-induced
methaemoglobinaemia. Br J Haematol. 1983;54(1):29-41.
- 15. Kumar YR, Kumar P, Prasad M, Radhika A, Edara AC.
Occupational inhalation of aniline fumes induced
methemoglobinemea and hemolytic anemia precipitated
days later. Indian Journal of Occupational and Environmental
Medicine. 2014;18(2):95-6.
- 16. Mier M.D RJ. Treatment of Aniline Poisoning with Exchange
Transfusion. Journal of Toxicology: Clinical Toxicology.
1988;26(5-6):357-64.
- 17. Lee CH, Kim SH, Kwon DH, Jang KH, Chung YH, Moon JD.
Two Cases of Methemoglobinemia Induced by the Exposure
to Nitrobenzene and Aniline. Annals of Occupational and
Environmental Medicine. 2013;25(1):31.
A Rare Case of Occupational Aniline Poisoning: Management in a Limited-Facility Setting
Year 2024,
Volume: 15 Issue: 4, 96 - 99, 25.12.2024
Behnaz Niroomand
,
Ibrahim Mohammadzadeh
,
Mitra Rahimi
,
Mohsen Bijandi
Abstract
Introduction
Cyanosis along with altered mental should bring all the possible ethiologies into her mind in a minimum of time, based on the trauma, medical, environmental, and occupational history of the patient. Poisoning with methemoglobinemia inducing agents is one of the most important differentials especially when a history of occupational exposure to these agents is present.
Case Report
The patient, a 41-year-old healthy woman and engineer, experienced symptoms after exposure to aniline leading to dizziness and weakness, prompting a visit to the emergency department with cyanosis and low oxygen saturation. Initial vital signs showed decreased oxygen levels and elevated respiratory rate with normal ABG values despite ongoing cyanosis. Patient required intubation, mechanical ventilation, and was diagnosed with ARDS based on chest X-ray findings. Management included IV diuretics, 100% oxygen, and antioxidant treatment in the ICU. Despite treatment, oxygen saturation remained at 88% on the first day.
Conclusion
This case is a reminder of the importance of taking occupational history and management of aniline toxicity in a setting where methylene blue, the drug of choice for aniline toxicity, is not available in the drug stock.
Ethical Statement
Ethical approval is not required since our patient's treatment was based on approved options, and it was not found to be controversial, according to the Ethics Committee of our institution (Iran National Committee for Ethics in Biomedical Research).
Supporting Institution
Not applicable.
References
- 1. Uter W, Stropp G, Schnuch A, Lessmann H. Aniline—A
‘Historical’Contact Allergen? Current Data from the IVDK
and Review of the Literature. The Annals of Occupational
Hygiene. 2007;51(2):219-26.
- 2. Wang Y, Gao H, Na X-L, Dong S-Y, Dong H-W, Yu J, et al. Aniline
induces oxidative stress and apoptosis of primary cultured
hepatocytes. International Journal of Environmental
Research and Public Health. 2016;13(12):1188.
- 3. Acute Exposure Guideline Levels for Selected Airborne
Chemicals: Volume 1. 2000 Available from: https://www.ncbi.
nlm.nih.gov/books/NBK222410/.
- 4. Di Girolamo F, Campanella L, Samperi R, Bachi A. Mass
spectrometric identification of hemoglobin modifications
induced by nitrosobenzene. Ecotoxicology and
Environmental Safety. 2009;72(5):1601-8.
- 5. Harrison J, Jollow D. Contribution of aniline metabolites
to aniline-induced methemoglobinemia. Molecular
pharmacology. 1987;32(3):423-31.
- 6. Fan X, Wang J, Soman KV, Ansari G, Khan MF. Aniline-induced
nitrosative stress in rat spleen: proteomic identification of
nitrated proteins. Toxicology and applied pharmacology.
2011;255(1):103-12.
- 7. Genkin S, Raschewskaja A. The Diagnosis of Chronic
Anilin Poisoning. Zentralblatt fur Gewerbehygiene und
Unfallverhutung. 1933;20:29-36.
- 8. LUBASH GD, PHILLIPS RE, SHIELDS JD, III, BONSNES RW. Acute
Aniline Poisoning Treated By Hemodialysis: Report of a Case.
Archives of Internal Medicine. 1964;114(4):530-2.
- 9. Cannata G, Abate L, Scarabello C, Rubini M, Giacometti A,
Principi N, et al. The Dose Makes the Poison: A Case Report
of Acquired Methemoglobinemia. International Journal of
Environmental Research and Public Health. 2020;17(6):1845.
- 10. Messmer AS, Nickel CH, Bareiss D. <i>P</i>-Chloroaniline
Poisoning Causing Methemoglobinemia: A Case Report
and Review of the Literature. Case Reports in Emergency
Medicine. 2015;2015:208732.
- 11. Wright RO, Lewander WJ, Woolf AD. Methemoglobinemia:
etiology, pharmacology, and clinical management. Ann
Emerg Med. 1999;34(5):646-56.
- 12. Hall AH, Kulig KW, Rumack BH. Drug- and chemical-induced
methaemoglobinaemia. Clinical features and management.
Med Toxicol. 1986;1(4):253-60.
- 13. Bradberry SM, Aw T-C, Williams NR, Vale JA. OCCUPATIONAL
METHAEMOGLOBINAEMIA. Occupational and Environmental
Medicine. 2001;58(9):611-.
- 14. Harvey JW, Keitt AS. Studies of the efficacy and potential
hazards of methylene blue therapy in aniline-induced
methaemoglobinaemia. Br J Haematol. 1983;54(1):29-41.
- 15. Kumar YR, Kumar P, Prasad M, Radhika A, Edara AC.
Occupational inhalation of aniline fumes induced
methemoglobinemea and hemolytic anemia precipitated
days later. Indian Journal of Occupational and Environmental
Medicine. 2014;18(2):95-6.
- 16. Mier M.D RJ. Treatment of Aniline Poisoning with Exchange
Transfusion. Journal of Toxicology: Clinical Toxicology.
1988;26(5-6):357-64.
- 17. Lee CH, Kim SH, Kwon DH, Jang KH, Chung YH, Moon JD.
Two Cases of Methemoglobinemia Induced by the Exposure
to Nitrobenzene and Aniline. Annals of Occupational and
Environmental Medicine. 2013;25(1):31.