A Rare Complication Due to Methanol Poisoning: MINOCA

Year 2025, Volume: 16 Issue: 2, 62 - 65, 29.06.2025

Erdem Aksay , Ahmet Burak Urfalioglu , Ayca Balta , Ali Isa Aslan , Yeliz Simsek , Hayri Çınar , Akkan Avci

Abstract

Introduction: Myocardial infarction with non-obstructive coronary arteries (MINOCA) is a relatively novel clinical puzzle characterized by limited research.
Case Report: In this case, we aimed to present the co-occurrence of methanol poisoning and MINOCA syndrome. This case demonstrates the importance of monitoring cardiac function with electrocardiography and cardiac biomarkers in patients within a high anion gap metabolic acidosis environment.
Conclusion: This case report is showing co-occurrences of MINOCA syndrome with methanol poisoning. This report is the first case of myocardial infarction in non-obstructive coronary arteries associated with methanol poisoning accompanied by high anion gap metabolic acidosis in the literature.

Keywords

MINOCA, metabolic asidosis, poisoning, emergency

Metanol Zehirlenmesinin Nadir Komplikasyonu:MINOCA

Abstract

Giriş: Tıkayıcı koroner arter hastalığı olmaksızın gelişen miyokart enfarktüsü (MINOCA), sınırlı bilgiler ile karakterize yeni bir klinik bulmacadır.
Olgu: Bu olguda, metanol zehirlenmesi ve MINOCA sendromunun birlikteliğini sunmayı amaçladık. Bu olgu, yüksek anyon açıklı metabolik asidozu olan hastalarda kardiyak fonksiyonunun elektrokardiyografi ve kardiyak biyobelirteçler ile izlenmesinin önemini vurgulamaktadır.
Sonuç: Bu vaka raporu, MINOCA sendromunun metanol zehirlenmesiyle birlikteliğini göstermektedir. Olgu, yüksek anyon açıklı metabolik asidozla birlikte görülen metanol zehirlenmesiyle ilişkili ilk MINOCA vakasıdır.

Keywords

MINOCA, zehirlenme, metabolik asidoz, acil

References

• 1. Takahashi J, Onuma S, Hao K, Godo S, Shiroto T, Yasuda S. Pathophysiology and diagnostic pathway of myocardial infarction with non-obstructive coronary arteries. J Cardiol 2024;83(1):17-24.
• 2. Bainey KR, Welsh RC, Alemayehu W, Westerhout CM, Traboulsi D, Anderson T, et al. Population-level incidence and outcomes of myocardial infarction with non-obstructive coronary arteries (MINOCA): Insights from the Alberta contemporary acute coronary syndrome patients invasive treatment strategies (COAPT) study. Int J Cardiol 2018;264:12-7.
• 3. Abdu FA, Mohammed AQ, Liu L, Xu Y, Che W. Myocardial Infarction with Nonobstructive Coronary Arteries (MINOCA): A Review of the Current Position. Cardiology 2020;145(9):543-52.
• 4. Cheema AN, Yanagawa B, Verma S, Bagai A, Liu S. Myocardial infarction with nonobstructive coronary artery disease (MINOCA): a review of pathophysiology and management. Curr Opin Cardiol 2021;36(5):589-96.
• 5. Agewall S, Beltrame JF, Reynolds HR, Niessner A, Rosano G, Caforio AL, et al. ESC working group position paper on myocardial infarction with non-obstructive coronary arteries. Eur Heart J 2017;38(3):143-153.
• 6. Magdalan J, Zawadzki M, Maksymowicz K. Fatal methanol poisoning complicated with acute coronary syndrome--a case report. Przegl Lek 2010; 67; 8: 610-2.
• 7. Boyaci F, Akcay M, Sahin MK, Erzincan M, Ucar M. Causation or coincidence? A case of methanol intoxication presenting with acute myocardial infarction and visual impairment. J Exp Clin Med 2024; 41(2): 436-439
• 8. Nikoo MH, Arjangzadeh A, Pakfetrat M, Boogar SS, Mohammadkarimi V, Ostovan VR, et al. Electrocardiographic findings of methanol toxicity: a cross-sectional study of 356 cases in Iran. BMC Cardiovasc Disord 2020; 20; 1: 415.