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Sulfonamide Antibiotics and Their Environmental Effects

Year 2022, Volume: 4 Issue: 1, 81 - 88, 20.04.2022
https://doi.org/10.53472/jenas.1060427

Abstract

Antibiotics have been used as medicinal drugs for over 50 years and have recently emerged as new pollutants in the environment. Worldwide, antibiotic use exceeds 100,000 tons per year. Sulfonamide antibiotics (SA's) are widely used in human and veterinary medicine. Pollution caused by antibiotics has emerged as a worldwide environmental problem in recent years and also affects natural food webs. This review covers the environmental effects of sulfonamide derived antibiotics. Transfer cycles from humans and animals, including their metabolic transformations, are discussed in the review. The results showed that; antibiotic metabolites are significantly persistent and localized to groundwater and drinking water. The information gathered can help scientists conduct further research into the status and transformation of antibiotics in the environment.

References

  • Aarestrup F. 2012. Get pigs off antibiotics. Nature, 486 (7404): 465.
  • Akgün H., vd. 2016. Farmasötik Kimya 2. Hacettepe Yayınları.
  • Blackwell, P.A., Kay, P., Ashauer, R., Boxall, A.B., 2009. Effects of agricultural conditions on the leaching behaviour of veterinary antibiotics in soils. Chemosphere 75, 13-19.
  • Boran H, Terzi E, Altinok I, Capkin E., Bascinar N. 2013. Bacterial Diseases of Cultured Mediterranean Horse Mackerel (Trachurus mediterraneus) in Sea Cages, Aquaculture, 8, 396-399.
  • Botelho, R.G.; Monteiro, S.H.; Tornisielo, V.L. 2015. Veterinary Antibiotics in the Environment. Chapter 5. Emerg. Pollut. Environ. Curr. Furth. Implic.
  • Boxall, A.B.A., Fogg, L.A., Baird, D.J., Lewis, C., Telfer, T.C., Kolpin, D., Gravell, A., 2005. Targeted monitoring study for veterinary medicines in the UK environment. Final Report to the UK Environmental Agency.
  • Boy-Roura, M., Mas-Pla, J., Petrovic, M., Gros, M., Soler, D., Brusi, D., Mencio, A., 2018. Towards the understanding of antibiotic occurrence and transport in groundwater:findings from the Baix Fluvia alluvial aquifer (NE Catalonia, Spain). Sci. Total Environ. 612, 1387-1406.
  • Cheong, M. S., Seo, K. H., Chohra, H., Yoon, Y. E., Choe, H., Kantharaj, V., Lee, Y. B. 2020. Influence of sulfonamide contamination derived from veterinary antibiotics on plant growth and development. Antibiotics, 9(8), 456. Demirer, B. ve Özdemir M. 2021. "Gıdalardaki Antibiyotik Kalıntıları." Academic Platform Journal of Halal Lifestyle 3.1: 17-25.
  • García-Galan, M.J., Garrido, T., Fraile, J., Ginebreda, A., Díaz-Cruz, M.S., Barcelo, D., 2010. Simultaneous occurrence of nitrates and sulfonamide antibiotics in two ground water bodies of Catalonia (Spain). J. Hydrol. 383, 93-101.
  • García-Galan, M.J., Díaz-Cruz, M.S., Barcelo, D., 2012. Removal of sulfonamide antibiotics upon conventional activated sludge and advanced membrane bioreactor treatment. Anal. Bioanal. Chem. 404, 1505-1515.
  • Graves AK, Liwimbi L, Israel DW, van Heugten E, Robinson B, Cahoon CW, Lubbers JF. 2011. Distribution of ten antibiotic resistance genes in E. coli isolates from swine manure, lagoon effluent and soil collected from a lagoon waste application field. Folia Microbiologica 56, 131–137.
  • Güngördü, A. 2018. Atıksulardan ileri arıtım yöntemleri ile antibiyotik giderimi. Diss. Anadolu Üniversitesi (Türkiye). Hamscher G., Pawelzick H. T., Hoper H., Nau H. 2005. Different behaviour of tetracyclines and sulfonamides in sandy soils after repeated fertilisation with liquid manure, Environ. Toxicol. Chem, 24, 861–868.
  • Hanson, A.D. ve Gregory, J.F. 2011. Folate Biosynthesis, Turnover, and Transport in Plants. Annu. Rev. Plant Biol, 62, 105–125.
  • Höper, H., Kues, J., Nau, H., Hamscher, G., 2002. Eintrag und Verbleib von Tierarzneimittelwirkstoffen in Böden. Bodenschutz 4, 141–148.
  • Hruska, K. ve Milan F. 2012. "Sulfonamides in the environment: a review and a case report." Vet Med 57.1, 1-35. Jorgensen S.E. ve Halling-Sørensen B. 2000. Drugs in the environment. Chemosphere 40, 691–699.
  • Kaya S., Pirinçci İ., Bilgili A., 1997. Veteriner Uygulamalı Farmakoloji (Cilt 2). Medisan Yayınevi, 1. Baskı, Ankara, Türkiye, 790 pp.
  • Kayaalp O., 1984. Rasyonel Tedavi Yönünden Tıbbi Farmakoloji. Ulucan Matbaası, Ankara, Türkiye, 995 pp.
  • Kemper N. 2008. Veterinary antibiotics in the aquatic and terrestrial environment, Ecological Indicators, 8, 1-13.
  • Kim S. ve Aga DS. 2007. Potential ecological and human health impacts of antibiotics and antibiotic-resistant bacteria from wastewater treatment plants. J. Toxicol Environ Health B Crit Rev, 10, 559-73.
  • Kim, K.R.; Owens, G.; Kwon, S.I.; So, K.H.; Lee, D.B.; Ok, Y.S. 2011. Occurrence and environmental fate of veterinary antibiotics in the terrestrial environment. Water. Air. Soil Pollut. 214, 163–174.
  • Klotz, I.M. 1944. The Mode of Action of Sulfonamides. J. Am. Chem. Soc., 66, 459–464.
  • Kümmerer K. 2001. Pharmaceuticals in the environment: Springer Berlin Heidelberg.
  • Kümmerer K. 2009. Antibiotics in the aquatic environment-a review-part I-II. Chemosphere, 75, 417-41.
  • Qin, L.-T., Pang, X.-R., Zeng, H.-H., Liang, Y.-P., Mo, L.-Y., Wang, D.-Q., Dai, J.-F., 2020. Ecological and human health risk of sulfonamides in surface water and groundwater of Huixian karst wetland in Guilin, China. Sci. Total Environ. 708, 134552.
  • Li, J., Cheng, W., Xu, L., Strong, P.J., Chen, H., 2015. Antibiotic-resistant genes and antibiotic-resistant bacteria in the effluent of urban residential areas, hospitals, and a municipal wastewater treatment plant system. Environ. Sci. Pollut. Control Ser. 22, 4587-4596.
  • Li, Yan-Wen, et al. 2011. "Investigation of sulfonamide, tetracycline, and quinolone antibiotics in vegetable farmland soil in the Pearl River Delta area, southern China." Journal of agricultural and food chemistry, 59.13, 7268-7276.
  • L. Zhao, Y.H. Dong. 2010. Residues of veterinary antibiotics in manures from feedlot livestock in eight provinces of China, Science of the Total Environment, 408: 1069-1075.
  • Özgüven, A. 2020. Veteriner İlaçlarının Çevrede Bulunuşu ve Etkileri. Bitlis Eren Üniversitesi Fen Bilimleri Dergisi, 9(1), 487-499.
  • Phuong Hoa PT, Nonaka L, Hung Viet P., Suzuki S. 2008. Detection of the Sul1, Sul2, and Sul3 Genes in Sulfonamide- Resistant Bacteria from Wastewater and Shrimp Ponds of North Vietnam, Science of the Total Environment, 405, 377-384.
  • Premasis, S. ve Spiteller, M. 2006. "Sulfonamides in the environment as veterinary drugs." Reviews of environmental contamination and toxicology, 187, 67-101.
  • Sarmah, A.K.; Meyer, M.T.; Boxall, A.B.A. 2006. A global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment. Chemosphere, 65, 725–759.
  • Schüller S. 1998. Anwendung antibiotisch wirksamer Substanzen beim tier und Beurteilung der Umweltsicherheit entsprechender Produkte. 3. Statuskolloquium okotoxikologischer Forschungen in der Euregio Bodensee, December 3–4, 1998.
  • Sköld O. 2001. Resistance to Trimethoprim and Sulfonamides, Veterinary Research, 32, 261-273.
  • Strauss, C., Harter, T., Radke, M., 2011. Effects of pH and manure on transport of sulfonamide antibiotics in soil. J. Environ. Qual. 40, 1652-1660.
  • Sukul P. ve Spiteller M. 2007. Fluoroquinolone antibiotics in the environment. Rev Environ Contam Toxicol , 191, 131-62.
  • Szekeres, E., Chiriac, C.M., Baricz, A., Szoke-Nagy, T., Lung, I., Soran, M.-L., Rudi, K., Dragos, N., Coman, C., 2018. Investigating antibiotics, antibiotic resistance genes, and microbial contaminants in groundwater in relation to the proximity of urban areas. Environ. Pollut. 236, 734-744.
  • Şahan, S., Battal, D., Şahin, N. 2012. "Çevre ve insan sağlığı yönünden ilaç atıklarının önemi." Marmara Pharmaceutical Journal 16.2, 82-90.
  • Thiele-Bruhn, S. 2003. Pharmaceutical antibiotic compounds in soils - A review. J. Plant Nutr. Soil Sci. 166, 145–167.
  • Tong, X.N.; Wang, X.Z.; He, X.J.; Wang, Z.; Li, W.X. 2020. Effects of antibiotics on microbial community structure and microbial functions in constructed wetlands treated with artificial root exudates. Environ. Sci. Process. Impacts, 22, 217–226.
  • Topal, M., Uslu. G., Öbek E. 2012. "Antibiyotiklerin kaynakları ve çevresel etkileri." Bitlis Eren Üniversitesi Fen Bilimleri Dergisi 1.2, 137-152.
  • Ware, George Whitaker, et al., (eds). 2006. Reviews of environmental contamination and toxicology. Springer.
  • Winckler C. ve Grafe A. 2000. Stoffeintrag durch Tierarzneimittel und pharmakologisch wirksame Futterzusatzstoffe unter besonderer Beru¨ cksichtigung von Tetrazyklinen, UBA-Texte 44/0, Berlin.
  • Yalap, K. S., Ak, I., Balcıoğlu, M., 2008, Oksitetrasiklinin ileri oksidasyon ile arıtımına su bileşenlerinin etkisi, İTÜ Dergisi Su Kirlenme Kontrolü, 18, 2-3, 51-60.
  • Yonar, M. Enis, ve Sağlam N. 2013. "Sülfonamidler ve Balıklarda Kullanımı." Menba Kastamonu Üniversitesi Su Ürünleri Fakültesi Dergisi 1.1, 37-42.

Sülfonamit Antibiyotikler ve Çevresel Etkileri

Year 2022, Volume: 4 Issue: 1, 81 - 88, 20.04.2022
https://doi.org/10.53472/jenas.1060427

Abstract

Antibiyotikler 50 yılı aşkın bir süredir tıbbi ilaçlar olarak kullanılmaktadır ve son zamanlarda çevrede yeni kirleticiler olarak ortaya çıkmıştır. Sülfonamit antibiyotikler (SA' lar), tıp ve veterinerlikte geniş çapta kullanılmaktadır. Antibiyotiklerin neden olduğu kirlilik, son yıllarda dünya çapında bir çevre sorunu olarak ortaya çıkmakta ve doğal gıda ağlarını da etkilemektedir. Bu derleme, sülfonamit türevi antibiyotiklerin çevredeki etkilerini kapsamaktadır. Derleme içeriğinde metabolik dönüşümleri de dahil olmak üzere insanlardan ve hayvanlardan transfer döngüsü ele alınmıştır. Sonuçlar göstermiştir ki; antibiyotik metabolitleri önemli ölçüde kalıcı olup, yeraltı sularına ve içme suyuna lokalize olmaktadır. Derlenen bilgiler, bilim adamlarının antibiyotiklerin durumu ve dönüşümü hakkında daha fazla araştırma yapmasına yardımcı olabilir.

References

  • Aarestrup F. 2012. Get pigs off antibiotics. Nature, 486 (7404): 465.
  • Akgün H., vd. 2016. Farmasötik Kimya 2. Hacettepe Yayınları.
  • Blackwell, P.A., Kay, P., Ashauer, R., Boxall, A.B., 2009. Effects of agricultural conditions on the leaching behaviour of veterinary antibiotics in soils. Chemosphere 75, 13-19.
  • Boran H, Terzi E, Altinok I, Capkin E., Bascinar N. 2013. Bacterial Diseases of Cultured Mediterranean Horse Mackerel (Trachurus mediterraneus) in Sea Cages, Aquaculture, 8, 396-399.
  • Botelho, R.G.; Monteiro, S.H.; Tornisielo, V.L. 2015. Veterinary Antibiotics in the Environment. Chapter 5. Emerg. Pollut. Environ. Curr. Furth. Implic.
  • Boxall, A.B.A., Fogg, L.A., Baird, D.J., Lewis, C., Telfer, T.C., Kolpin, D., Gravell, A., 2005. Targeted monitoring study for veterinary medicines in the UK environment. Final Report to the UK Environmental Agency.
  • Boy-Roura, M., Mas-Pla, J., Petrovic, M., Gros, M., Soler, D., Brusi, D., Mencio, A., 2018. Towards the understanding of antibiotic occurrence and transport in groundwater:findings from the Baix Fluvia alluvial aquifer (NE Catalonia, Spain). Sci. Total Environ. 612, 1387-1406.
  • Cheong, M. S., Seo, K. H., Chohra, H., Yoon, Y. E., Choe, H., Kantharaj, V., Lee, Y. B. 2020. Influence of sulfonamide contamination derived from veterinary antibiotics on plant growth and development. Antibiotics, 9(8), 456. Demirer, B. ve Özdemir M. 2021. "Gıdalardaki Antibiyotik Kalıntıları." Academic Platform Journal of Halal Lifestyle 3.1: 17-25.
  • García-Galan, M.J., Garrido, T., Fraile, J., Ginebreda, A., Díaz-Cruz, M.S., Barcelo, D., 2010. Simultaneous occurrence of nitrates and sulfonamide antibiotics in two ground water bodies of Catalonia (Spain). J. Hydrol. 383, 93-101.
  • García-Galan, M.J., Díaz-Cruz, M.S., Barcelo, D., 2012. Removal of sulfonamide antibiotics upon conventional activated sludge and advanced membrane bioreactor treatment. Anal. Bioanal. Chem. 404, 1505-1515.
  • Graves AK, Liwimbi L, Israel DW, van Heugten E, Robinson B, Cahoon CW, Lubbers JF. 2011. Distribution of ten antibiotic resistance genes in E. coli isolates from swine manure, lagoon effluent and soil collected from a lagoon waste application field. Folia Microbiologica 56, 131–137.
  • Güngördü, A. 2018. Atıksulardan ileri arıtım yöntemleri ile antibiyotik giderimi. Diss. Anadolu Üniversitesi (Türkiye). Hamscher G., Pawelzick H. T., Hoper H., Nau H. 2005. Different behaviour of tetracyclines and sulfonamides in sandy soils after repeated fertilisation with liquid manure, Environ. Toxicol. Chem, 24, 861–868.
  • Hanson, A.D. ve Gregory, J.F. 2011. Folate Biosynthesis, Turnover, and Transport in Plants. Annu. Rev. Plant Biol, 62, 105–125.
  • Höper, H., Kues, J., Nau, H., Hamscher, G., 2002. Eintrag und Verbleib von Tierarzneimittelwirkstoffen in Böden. Bodenschutz 4, 141–148.
  • Hruska, K. ve Milan F. 2012. "Sulfonamides in the environment: a review and a case report." Vet Med 57.1, 1-35. Jorgensen S.E. ve Halling-Sørensen B. 2000. Drugs in the environment. Chemosphere 40, 691–699.
  • Kaya S., Pirinçci İ., Bilgili A., 1997. Veteriner Uygulamalı Farmakoloji (Cilt 2). Medisan Yayınevi, 1. Baskı, Ankara, Türkiye, 790 pp.
  • Kayaalp O., 1984. Rasyonel Tedavi Yönünden Tıbbi Farmakoloji. Ulucan Matbaası, Ankara, Türkiye, 995 pp.
  • Kemper N. 2008. Veterinary antibiotics in the aquatic and terrestrial environment, Ecological Indicators, 8, 1-13.
  • Kim S. ve Aga DS. 2007. Potential ecological and human health impacts of antibiotics and antibiotic-resistant bacteria from wastewater treatment plants. J. Toxicol Environ Health B Crit Rev, 10, 559-73.
  • Kim, K.R.; Owens, G.; Kwon, S.I.; So, K.H.; Lee, D.B.; Ok, Y.S. 2011. Occurrence and environmental fate of veterinary antibiotics in the terrestrial environment. Water. Air. Soil Pollut. 214, 163–174.
  • Klotz, I.M. 1944. The Mode of Action of Sulfonamides. J. Am. Chem. Soc., 66, 459–464.
  • Kümmerer K. 2001. Pharmaceuticals in the environment: Springer Berlin Heidelberg.
  • Kümmerer K. 2009. Antibiotics in the aquatic environment-a review-part I-II. Chemosphere, 75, 417-41.
  • Qin, L.-T., Pang, X.-R., Zeng, H.-H., Liang, Y.-P., Mo, L.-Y., Wang, D.-Q., Dai, J.-F., 2020. Ecological and human health risk of sulfonamides in surface water and groundwater of Huixian karst wetland in Guilin, China. Sci. Total Environ. 708, 134552.
  • Li, J., Cheng, W., Xu, L., Strong, P.J., Chen, H., 2015. Antibiotic-resistant genes and antibiotic-resistant bacteria in the effluent of urban residential areas, hospitals, and a municipal wastewater treatment plant system. Environ. Sci. Pollut. Control Ser. 22, 4587-4596.
  • Li, Yan-Wen, et al. 2011. "Investigation of sulfonamide, tetracycline, and quinolone antibiotics in vegetable farmland soil in the Pearl River Delta area, southern China." Journal of agricultural and food chemistry, 59.13, 7268-7276.
  • L. Zhao, Y.H. Dong. 2010. Residues of veterinary antibiotics in manures from feedlot livestock in eight provinces of China, Science of the Total Environment, 408: 1069-1075.
  • Özgüven, A. 2020. Veteriner İlaçlarının Çevrede Bulunuşu ve Etkileri. Bitlis Eren Üniversitesi Fen Bilimleri Dergisi, 9(1), 487-499.
  • Phuong Hoa PT, Nonaka L, Hung Viet P., Suzuki S. 2008. Detection of the Sul1, Sul2, and Sul3 Genes in Sulfonamide- Resistant Bacteria from Wastewater and Shrimp Ponds of North Vietnam, Science of the Total Environment, 405, 377-384.
  • Premasis, S. ve Spiteller, M. 2006. "Sulfonamides in the environment as veterinary drugs." Reviews of environmental contamination and toxicology, 187, 67-101.
  • Sarmah, A.K.; Meyer, M.T.; Boxall, A.B.A. 2006. A global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment. Chemosphere, 65, 725–759.
  • Schüller S. 1998. Anwendung antibiotisch wirksamer Substanzen beim tier und Beurteilung der Umweltsicherheit entsprechender Produkte. 3. Statuskolloquium okotoxikologischer Forschungen in der Euregio Bodensee, December 3–4, 1998.
  • Sköld O. 2001. Resistance to Trimethoprim and Sulfonamides, Veterinary Research, 32, 261-273.
  • Strauss, C., Harter, T., Radke, M., 2011. Effects of pH and manure on transport of sulfonamide antibiotics in soil. J. Environ. Qual. 40, 1652-1660.
  • Sukul P. ve Spiteller M. 2007. Fluoroquinolone antibiotics in the environment. Rev Environ Contam Toxicol , 191, 131-62.
  • Szekeres, E., Chiriac, C.M., Baricz, A., Szoke-Nagy, T., Lung, I., Soran, M.-L., Rudi, K., Dragos, N., Coman, C., 2018. Investigating antibiotics, antibiotic resistance genes, and microbial contaminants in groundwater in relation to the proximity of urban areas. Environ. Pollut. 236, 734-744.
  • Şahan, S., Battal, D., Şahin, N. 2012. "Çevre ve insan sağlığı yönünden ilaç atıklarının önemi." Marmara Pharmaceutical Journal 16.2, 82-90.
  • Thiele-Bruhn, S. 2003. Pharmaceutical antibiotic compounds in soils - A review. J. Plant Nutr. Soil Sci. 166, 145–167.
  • Tong, X.N.; Wang, X.Z.; He, X.J.; Wang, Z.; Li, W.X. 2020. Effects of antibiotics on microbial community structure and microbial functions in constructed wetlands treated with artificial root exudates. Environ. Sci. Process. Impacts, 22, 217–226.
  • Topal, M., Uslu. G., Öbek E. 2012. "Antibiyotiklerin kaynakları ve çevresel etkileri." Bitlis Eren Üniversitesi Fen Bilimleri Dergisi 1.2, 137-152.
  • Ware, George Whitaker, et al., (eds). 2006. Reviews of environmental contamination and toxicology. Springer.
  • Winckler C. ve Grafe A. 2000. Stoffeintrag durch Tierarzneimittel und pharmakologisch wirksame Futterzusatzstoffe unter besonderer Beru¨ cksichtigung von Tetrazyklinen, UBA-Texte 44/0, Berlin.
  • Yalap, K. S., Ak, I., Balcıoğlu, M., 2008, Oksitetrasiklinin ileri oksidasyon ile arıtımına su bileşenlerinin etkisi, İTÜ Dergisi Su Kirlenme Kontrolü, 18, 2-3, 51-60.
  • Yonar, M. Enis, ve Sağlam N. 2013. "Sülfonamidler ve Balıklarda Kullanımı." Menba Kastamonu Üniversitesi Su Ürünleri Fakültesi Dergisi 1.1, 37-42.
There are 44 citations in total.

Details

Primary Language Turkish
Subjects Public Health, Environmental Health
Journal Section Review
Authors

Dilan Özmen Özgün 0000-0002-8574-9672

Turgut Seçkin Gül This is me 0000-0002-3615-4760

Publication Date April 20, 2022
Published in Issue Year 2022 Volume: 4 Issue: 1

Cite

APA Özmen Özgün, D., & Gül, T. S. (2022). Sülfonamit Antibiyotikler ve Çevresel Etkileri. JENAS Journal of Environmental and Natural Studies, 4(1), 81-88. https://doi.org/10.53472/jenas.1060427

JENAS | Journal of Environmental and Natural Search / Studies | JENAS | Çevresel ve Doğal Araştırmalar / Çalışmalar Dergisi