Metal Oksit Nanopartiküllerin Genotoksik Etkileri

Yasemin Saygılı; Deniz Yüzbaşıoğlu; Fatma Ünal

doi:10.7240/jeps.875709

Metal Oksit Nanopartiküllerin Genotoksik Etkileri

Abstract

Nanopartiküller (NP) (Nanomateryaller-NM), hızla gelişen nanoteknolojide çığır açan partiküllerdir. Bu partiküllerin en az bir boyutu 1-100 nm aralığındadır. Metal oksit nanopartikülleri, nanomateryallerin temel üyelerinden biri olup, tıp, kozmetik, boya, tekstil ve gıda ürünleri gibi çok çeşitli alanlarda yaygın bir şekilde kullanılmaktadır. Metal oksit NP’lerinin yoğun kullanımı, insanların partiküllere inhalasyon, dermal ve oral yollar dahil çeşitli yollarla maruz kalmasına sebep olmaktadır. Diğer taraftan, nanopartiküllere böylesi yoğun maruziyet, partiküllerin olası toksisitesi konusunda endişelerin artmasına sebep olmuştur. Metal oksit nanopartiküllerin şekil ve ebatlarına ilave olarak diğer fizikokimyasal özellikleri de, NP’lerin toksik etkilerinde de önemli rol oynamaktadır. Metal oksit nanopartiküllerinin toksisitesi konusunda yapılan araştırmalar, bazı partiküllerin genotoksik olduğunu ve dolayısıyla insanlar için de zararlı olabileceğini göstermektedir. Bu nedenle bu çalışmada Al2O3, CeO2, CuO, Fe2O3, SiO2, TiO2 ve ZnO nanopartiküllerinin genotoksik etkileri derlenmiştir. Makalede kromozom anomali analizleri ile Ames (bakteriyel geri mutasyon), mikronukleus ve komet testleri kullanılarak yürütülen bazı araştırmalar dikkate alınmıştır. Derlemenin sonunda, metal oksit nanopartiküllerinin genotoksik mekanizmaları konusunda ileri sürülen görüşler sunulmuştur.

Keywords

Supporting Institution

Gazi Üniversitesi

Project Number

05/2011-74

Thanks

Bu çalışma, 05/2011-74 numaralı Gazi Üniversitesi, Bilimsel Araştırma Projesi kapsamında kısmen desteklenmiştir.

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Details

Primary Language

Turkish

Subjects

-

Journal Section

Review

Authors

Yasemin Saygılı
0000-0003-0903-0313
Türkiye

Deniz Yüzbaşıoğlu
0000-0003-2756-7712
Türkiye

Fatma Ünal ^*
0000-0002-7468-6186
Türkiye

Publication Date

September 1, 2021

Submission Date

February 8, 2021

Acceptance Date

May 4, 2021

Published in Issue

Year 2021 Volume: 33 Number: 3

DOI

https://doi.org/10.7240/jeps.875709

IZ

https://izlik.org/JA49FY65BY

Cite

RIS / Bibtex

APA

Saygılı, Y., Yüzbaşıoğlu, D., & Ünal, F. (2021). Metal Oksit Nanopartiküllerin Genotoksik Etkileri. International Journal of Advances in Engineering and Pure Sciences, 33(3), 429-443. https://doi.org/10.7240/jeps.875709

AMA

1.Saygılı Y, Yüzbaşıoğlu D, Ünal F. Metal Oksit Nanopartiküllerin Genotoksik Etkileri. JEPS. 2021;33(3):429-443. doi:10.7240/jeps.875709

Chicago

Saygılı, Yasemin, Deniz Yüzbaşıoğlu, and Fatma Ünal. 2021. “Metal Oksit Nanopartiküllerin Genotoksik Etkileri”. International Journal of Advances in Engineering and Pure Sciences 33 (3): 429-43. https://doi.org/10.7240/jeps.875709.

EndNote

Saygılı Y, Yüzbaşıoğlu D, Ünal F (September 1, 2021) Metal Oksit Nanopartiküllerin Genotoksik Etkileri. International Journal of Advances in Engineering and Pure Sciences 33 3 429–443.

IEEE

[1]Y. Saygılı, D. Yüzbaşıoğlu, and F. Ünal, “Metal Oksit Nanopartiküllerin Genotoksik Etkileri”, JEPS, vol. 33, no. 3, pp. 429–443, Sept. 2021, doi: 10.7240/jeps.875709.

ISNAD

Saygılı, Yasemin - Yüzbaşıoğlu, Deniz - Ünal, Fatma. “Metal Oksit Nanopartiküllerin Genotoksik Etkileri”. International Journal of Advances in Engineering and Pure Sciences 33/3 (September 1, 2021): 429-443. https://doi.org/10.7240/jeps.875709.

JAMA

1.Saygılı Y, Yüzbaşıoğlu D, Ünal F. Metal Oksit Nanopartiküllerin Genotoksik Etkileri. JEPS. 2021;33:429–443.

MLA

Saygılı, Yasemin, et al. “Metal Oksit Nanopartiküllerin Genotoksik Etkileri”. International Journal of Advances in Engineering and Pure Sciences, vol. 33, no. 3, Sept. 2021, pp. 429-43, doi:10.7240/jeps.875709.

Vancouver

1.Yasemin Saygılı, Deniz Yüzbaşıoğlu, Fatma Ünal. Metal Oksit Nanopartiküllerin Genotoksik Etkileri. JEPS. 2021 Sep. 1;33(3):429-43. doi:10.7240/jeps.875709