Effect of different exercise model on inflammatory predictors and metabolic parameters in experimentally induced type 2 diabetes model

Abstract

Purpose: It was aimed to compare the effect of aerobic exercise and resistant exercise training on metabolic parameters and inflammatory predictors in rat type 2 diabetes model in our study.

Methods: The study was performed on 14 male rats with type 2 diabetes. The subjects were divided into three groups as aerobic exercise group (N=5), resistive exercise group (n:4) and control group (N=5). The aerobic exercise group were performed 45-60 minutes of swimming training, resistance exercise group were adapted to climb stairs with weights that were 75-100 % of the body weight attached to their tails for 6 weeks 3 times a week. The blood glucose level was determined by glucometer by taking blood from the tail vein. After exercise training, the metabolic parameters (cholesterol, triglycerides, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), hemoglobinA1c (HbA1c), insulin), inflammatory predictors (tumor necrosis factor alpha (TNF-α), interleukin1-β (IL-1β), interleukin-6 (IL-6) were determined taking blood from the hearts of the subjects under anesthesia by the respective kits.

Results: The glucose, TNF-α, IL-1β and IL-6 levels were significantly lower in the aerobic exercise group than in the other groups (p<0.05). The measured others parameters were no significant differences between the three groups (p>0.05).

Conclusion: The results of the study can be a pioneer in the planning and implementation of human studies in order to make the right exercise selection in type 2 diabetes. We think that aerobic exercise training improves glycemic control and has an anti-inflammatory effect in the type 2 diabetes model.

Keywords

• Diabetes,Exercise,Blood glucose,Dyslipidemia,Inflamation

Deneysel olarak oluşturulan tip 2 diyabet modelinde farklı egzersiz modellerinin inflamatuar belirleyiciler ve metabolik parametreler üzerine etkisi

Abstract

Amaç: Çalışmamızda, sıçanlarda deneysel olarak oluşturulan tip 2 diyabet modelinde aerobik egzersiz ve dirençli egzersiz eğitiminin metabolik parametreler ve inflamatuar belirleyiciler üzerine etkisinin karşılaştırılması amaçlandı.

Yöntem: Çalışma tip 2 diyabet oluşturulan 14 adet erkek sıçan üzerinde gerçekleştirildi. Denekler aerobik egzersiz grubu (N=5), dirençli egzersiz grubu (N=5), kontrol grubu (n=4) olacak şekilde 3 gruba ayrıldı. Aerobik egzersiz grubu 45-60 dk yüzme egzersizi, dirençli egzersiz grubu vücut ağırlıklarının %75-100’ü kadar ağırlık kuyruklarına bağlanarak merdiven çıkma egzersizini 6 hafta, haftada 3 gün gerçekleştirdiler. Kan glikoz seviyesi kuyruk veninden kan alınarak glukometre ile belirlendi. Egzersiz eğitimi sonunda anestezi uygulanan deneklerin kalplerinden kan alınarak metabolik parametreler (Kolesterol, trigliserit, yüksek yoğunluklu lipoprotein kolesterol (HDL-C), düşük yoğunluklu lipoprotein kolesterol (LDL-C), hemoglobin A1c (HbA1c), insülin), inflamatuar belirleyiciler (tümör nekroz faktörü alfa(TNF-α), interlökin1-β (IL-1β), interlökin-6 (IL-6) ilgili kitler ile belirlendi.

Bulgular: Aerobik egzersiz grubunda glikoz, TNF-α, IL-1β ve IL-6 düzeyleri diğer grupları göre istatistiksel olarak anlamlı şekilde daha düşük bulundu (p<0,05). Ölçülen diğer parametrelerde üç grup arasında anlamlı fark bulunmamıştır (p>0,05).

Sonuç: Çalışmadan elde edilen sonuçlar, tip 2 diyabette doğru egzersiz seçiminin yapılabilmesi için insanda yapılacak çalışmaların planlanmasında ve gerçekleştirilmesinde öncü bir nitelik taşıyabilecektir. Aerobik egzersiz eğitimin tip 2 diyabet modelinde glisemik kontrolü iyileştirdiği ve anti-inflamatuar etki yarattığını düşünmekteyiz.

Keywords

• Diyabet,Egzersiz,Kan Glukozu,Dislipidemi,İnflamasyon

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