PISTACIA LENTISCUS L. TÜRÜNÜN BOTANİK, ETNOFARMAKOLOJİK, FİTOKİMYASAL VE FARMAKOLOJİK AKTİVİTELERİNİN DEĞERLENDİRİLMESİ

Year 2022, , 576 - 599, 29.05.2022

Sultan Pekacar , Didem Deliorman Orhan

https://doi.org/10.33483/jfpau.1080466

Abstract

Amaç: Pistacia, içerisinde P. lentiscus gibi tıbbi türleri ihtiva eden Anacardiaceae familyasına ait, Akdeniz havzası boyunca yaygın dağılıma sahip bir cinstir. P. lentiscus’un çeşitli kısımları geleneksel tıpta pek çok hastalığın tedavisinde kullanılmaktadır. Bu derlemede, P. lentiscus türünün botanik özellikleri, geleneksel kullanımları, fitokimyasal içeriği ve farmakolojik aktiviteleri ile ilgili kapsamlı bilgiler özetlenmeye çalışılmıştır.

Sonuç ve Tartışma: Literatür taramaları bu türün antioksidan, antimutajenik, animikrobiyal, antiviral, antienflamatuvar, gastrointestinal hastalıklar, karaciğer ve serum biyokimyasal parametreler üzerindeki etkileri, antiaterosklerotik ve antidiyabetik, antiparaziter, antitümör, antikolinesteraz, nöroprotektif ve yara iyileştirici aktivitelerin de olduğu çok çeşitli farmakolojik aktiviteler bakımından değerlendirildiğini göstermiştir. P. lentiscus terpenoitler, fenolik bileşikler, yağ asitleri ve steroller gibi çeşitli fitokimyasal bileşenleri ihtiva etmektedir. Yapılan araştırma sonucunda P. lentiscus türünün çeşitli farmasötik şekillerde doğal kaynaklı ilaçların geliştirilmesi ve ticarileştirilmesi için önemli bir kaynak olduğu, ama risk faktörlerini daha iyi aydınlatmak adına daha fazla preklinik ve klinik çalışmaya gereksinim duyulduğu sonucuna varılmıştır.

Keywords

Etnofarmakoloji, farmakolojik aktivite, fitokimya, Pistacia, Pistacia lentiscus

EVALUATION OF BOTANICAL, ETHNOPHARMACOLOGICAL, PHYTOCHEMICAL AND PHARMACOLOGICAL ACTIVITY OF PISTACIA LENTISCUS L. SPECIES

Abstract

Objective: Pistacia is a genus with widespread distribution throughout the Mediterranean basin, belonging to the Anacardiaceae family, which includes species such as P. lentiscus. Various parts of the P. lentiscus species are used in traditional medicine for the treatment of many diseases. In this review, comprehensive information about the botanical features, traditional uses, phytochemical content and pharmacological activities of P. lentiscus has been tried to be summarized.

Result and Discussion: Literature surveys have shown that this species has been evaluated for a wide variety of pharmacological activities, including antioxidant, antimutagenic, antimicrobial, antiviral, anti-inflammatory, gastrointestinal diseases, effects on liver and serum biochemical parameters, antiatherosclerotic and antidiabetic, antiparasitic, antitumor, anticholinesterase, neuroprotective and wound healing activities. P. lentiscus contains various phytochemical components such as terpenoids, phenolic compounds, fatty acids and sterols. As a result of the research, it was concluded that the P. lentiscus species is an important resource for the development and commercialization of natural origin drugs in various pharmaceutical forms, but more preclinical and clinical studies are needed to better elucidate the risk factors.

Keywords

Ethnopharmacology, pharmacological activity, phytochemistry, Pistacia, Pistacia lentiscus

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