TAURINE PREVENTS AGAINST 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN-INDUCED OXIDATIVE STRESS IN THE LIVER AND KIDNEY OF RATS

Muhammed Fatih Doğan; Osman Çiftçi; Neşe Başak Türkmen; Aslı Çetin; Münevver Nazlıcan Zengin; Bedriye Çiftçi

doi:10.33483/jfpau.1085253

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TAURİN, SIÇAN KARACIĞER VE BÖBREK DOKULARINDA 2,3,7,8-TETRAKLORODİBENZO-P-DİOKSİN KAYNAKLI OKSİDATİF STRESİ ÖNLER

Year 2023, Volume: 47 Issue: 2, 394 - 407, 20.05.2023

Muhammed Fatih Doğan , Osman Çiftçi , Neşe Başak Türkmen , Aslı Çetin , Münevver Nazlıcan Zengin , Bedriye Çiftçi

https://doi.org/10.33483/jfpau.1085253

https://izlik.org/JA28MB54JC

Abstract

Amaç: Çalışmanın amacı, sıçanlarda 2,3,7,8- tetrachlorodibenzo-p-dioksin (TCDD) kaynaklı organ hasarına karşı taurinin önleyici etkilerinin araştırılmasıdır. Çevresel toksin TCDD, hayvan ve insan dokularında yüksek toksisiteye sahiptir. Taurin, birçok organda bulunan bir amino asit olup, antioksidan ve antienflamatuar özellikleri ile hücrelerin korunmasında görev alır. Bu kapsamda, bu çalışmadaki amacımız, TCDD'nin sıçan karaciğer ve böbrek dokularında neden olduğu oksidatif stres ve organ hasarları üzerinde taurinin potansiyel önleyici etkisini araştırmaktır. Bu olası etkileri değerlendirmek üzere, tiyobarbitürik asitle reaksiyona giren reaktif maddeler (TBARS) ve glutatyon (GSH) düzeylerinin yanı sıra süperoksit dismutazın (SOD) aktivitesi ölçülmüştür. Ayrıca, kaspaz-3 ekspresyonunun immünohistokimyasal tespiti ve doku örneklerinde histopatolojik değişikliklerin değerlendirilmesi gerçekleştirilmiştir.
Gereç ve Yöntem: Yetişkin erkek Wistar sıçanları (250-300 g, 12-13 hafta, n = 32) rastgele dört gruba (n = 8/grup) ayrıldı: Kontrol, TCDD, TAU ve TCDD+TAU. TCDD ve/veya taurin gavaj yoluyla sırasıyla 2 μg/kg/hafta ve 200 mg/kg/gün dozlarında uygulandı.
Sonuç ve Tartışma: Bulgular, TCDD'nin GSH düzeyi ve SOD aktivitesini azaltarak ve TBARS düzeylerini artırarak sıçanların karaciğer ve böbrek dokularında oksidatif strese neden olduğunu göstermiştir. Taurin uygulaması, TCDD ve taurinin eşzamanlı uygulamasında TBARS düzeylerinde önemli ölçüde azalma (p<0.05), GSH düzeylerinde ve SOD aktivitesinde ise önemli ölçüde artış sağlamıştır (p<0.05). TCDD'nin karaciğer ve böbrek dokularında neden olduğu oksidatif kaynaklı histopatolojik değişiklikler de taurin uygulaması ile azalmıştır. Taurin, sistein aspartat spesifik proteaz-3'ü (kaspaz-3) azaltarak apoptotik yolağı engelledi. Taurin takviyesi, oksidatif dengesizliği düzenlemeye yardımcı olmakta ve TCDD'nin neden olduğu organ hasarının göstergesi olan histopatolojik değişiklikleri azaltmaktadır. Bu, TCDD toksisitesinden kaçınmak için yeni bir yaklaşım olabilir.

Keywords

Oksidatif stres , sıçanlar , taurin , TCDD

References

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17. Adedara, I.A., Alake, S.E., Adeyemo, M.O., Olajide, L.O., Ajibade, T.O., Farombi, E.O. (2018). Taurine enhances spermatogenic function and antioxidant defense mechanisms in testes and epididymis of L-NAME-induced hypertensive rats. Biomedicine and Pharmacotherapy, 97, 181-189. [CrossRef]
18. Ciftci, O., Ozdemir, I., Tanyildizi, S., Yildiz, S., Oguzturk, H. (2011). Antioxidative effects of curcumin, β-myrcene and 1,8-cineole against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced oxidative stress in rats liver. Toxicology and Industrial Health, 27(5), 447-453. [CrossRef]
19. Ciftci, O., Disli, O.M., Timurkaan, N. (2013). Protective effects of protocatechuic acid on TCDD-induced oxidative and histopathological damage in the heart tissue of rats. Toxicology and Industrial Health, 29(9), 806–811. [CrossRef]
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22. Caglayan, C., Kandemir, F.M., Yildirim, S., Kucukler, S., Eser, G. (2019). Rutin protects mercuric chloride‐induced nephrotoxicity via targeting of aquaporin 1 level, oxidative stress, apoptosis and inflammation in rats. Journal of Trace Elements in Medicine and Biology, 54, 69-78. [CrossRef]
23. Pal, G., Behl, T., Rohil, V., Khandelwal, M., Gupta, G., Jena, J. (2020). Evaluation of oxidative stress and its modulation by L-arginine and L-ascorbic acid in repetitive restraint stress model in Wistar rats. Obesity Medicine, 17, 100172. [CrossRef]
24. Hassoun, E.A., Al-Ghafri, M., Abushaban, A. (2003). The role of antioxidant enzymes in TCDD-induced oxidative stress in various brain regions of rats after subchronic exposure. Free Radical Biology and Medicine, 35(9), 1028-1036. [CrossRef]
25. Patrizi, B., Cumis, M.S. (2018). TCDD Toxicity Mediated by Epigenetic Mechanisms. International Journal of Molecular Sciences, 19, 1-15. [CrossRef]
26. Fernandez-Salguero, P.M., Hllbert, D.M., Rudikoff, S., Ward, J.M., Gonzalez, F.J. (1996). Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity. Toxicology and Applied Pharmacology, 140(1), 173-179. [CrossRef]
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TAURINE PREVENTS AGAINST 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN-INDUCED OXIDATIVE STRESS IN THE LIVER AND KIDNEY OF RATS

Year 2023, Volume: 47 Issue: 2, 394 - 407, 20.05.2023

Muhammed Fatih Doğan , Osman Çiftçi , Neşe Başak Türkmen , Aslı Çetin , Münevver Nazlıcan Zengin , Bedriye Çiftçi

https://doi.org/10.33483/jfpau.1085253

https://izlik.org/JA28MB54JC

Abstract

Objective: The aim of the study was to investigate the preventive effects of taurine against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced organ damage in rats. The environmental toxin TCDD has a high toxicity in animal and human tissues. Taurine is an amino acid found in many organs, with multiple physiological roles including the protection of cells with its antioxidant and anti-inflammatory properties. In this context, our aim in this study was to investigate the potential preventive effect of taurine on oxidative stress and organ damage caused by TCDD in rat liver and kidney tissues. To evaluate these possible effects, we measured the levels of thiobarbituric acid reactive substances (TBARS), and glutathione (GSH), as well as the activity of superoxide dismutase (SOD). In addition, immunohistochemical detection of caspase-3 expression, and the assessment of histopathological changes in tissue samples were performed.
Material and Method: Adult male Wistar rats (250-300 g, 12-13 weeks, n = 32) were randomly allocated into four groups (n = 8/group): Control, TCDD, TAU, and TCDD+TAU. TCDD and/or taurine were administered via gavage in doses of 2 μg/kg/week and 200 mg/kg/day, respectively.
Result and Discussion: The results showed that TCDD caused oxidative stress in the liver and kidney tissues of rats by decreasing the levels of GSH and SOD activity and increasing the levels of TBARS. Taurine treatment significantly reduced TBARS levels (p<0.05), it significantly increased GSH levels and SOD activity (p<0.05) in the concurrent administration of TCDD and taurine. Taurine also reduced the histopathological changes caused by TCDD-induced oxidative stress in the liver and kidney tissues. Taurine prevented the apoptotic pathway by decreasing cysteine aspartate specific protease-3 (caspase-3). Taurine supplementation helps to regulate oxidative imbalance and reduces histopathological changes caused by TCDD-induced organ damage. This could be a novel approach to avoiding TCDD toxicity.

Keywords

Oxidative stress , rats , taurine , TCDD

References

1. Pelclová, D., Urban, P., Preiss, J., Lukáš, E., Fenclová, Z., Navrátil, T., Dubská, Z., Šenholdova, Z. (2006). Adverse health effects in humans exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Reviews on Environmental Health 21(2), 119-138. [CrossRef]
2. Geyer, H.J., Schheunert, I., Rapp, K., Gebefugi, I., Steinberg, C., Kettrup, A. (1993). The Relevance of Fat Content in Toxicity of Lipophilic Chemicals to Terrestrial Animals with Special Reference to Dieldrin and 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD). Ecotoxicology and Environmental Safety, 26(1), 45-60. [CrossRef]
3. Doskey, C.M., Fader, K.A., Nault, R., Lydic, T., Matthews, J., Potter, D., Sharratt, B., Williams, K., Zacharewski, T. (2020). 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters hepatic polyunsaturated fatty acid metabolism and eicosanoid biosynthesis in female Sprague-Dawley rats. Toxicology and Applied Pharmacology, 398, 115034. [CrossRef]
4. Ciftci, O., Ozdemir, I., Vardi, N., Beytur, A., Oguz, F. (2012). Ameliorating effects of quercetin and chrysin on 2,3,7,8- tetrachlorodibenzo- p-dioxin-induced nephrotoxicity in rats. Toxicology and Industrial Health, 28(40), 947-954. [CrossRef]
5. Li, X., Li, N., Han, Y., Rao, K., Ji, X., Ma, M. (2021). 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced suppression of immunity in THP-1-derived macrophages and the possible mechanisms. Environmental Pollution, 287, 117302. [CrossRef]
6. Beytur, A., Ciftci, O., Aydin, M., Cakir, O., Timurkaan, N.Y.F. (2012). Protocatechuic acid prevents reproductive damage caused by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) in male rats. Andrologia, 44, 454-461.[CrossRef]
7. Mimura, J., Fujii-Kuriyama, Y. (2003). Functional role of AhR in the expression of toxic effects by TCDD. Biochimica et Biophysica Acta - General Subjects, 1619(3), 263-268. [CrossRef]
8. Reichard, J.F., Dalton, T.P., Shertzer, H. G., Puga, A. (2005). Induction of Oxidative Stress Responses by Dioxin and other Ligands of the Aryl Hydrocarbon Receptor. Dose-Response, 3(3), 306-331. [CrossRef]
9. Kalaiselvan, I., Samuthirapandi, M., Govindaraju, A., Sheeja Malar, D., Kasi, P.D. (2016). Olive oil and its phenolic compounds (hydroxytyrosol and tyrosol) ameliorated TCDD-induced heptotoxicity in rats via inhibition of oxidative stress and apoptosis. Pharmaceutical Biology, 54(2), 338-346. [CrossRef]
10. Ciftci, O., Aydin, M., Ozdemir, I., Vardi, N. (2012). Quercetin prevents 2,3,7,8-tetrachlorodibenzo-p-dioxin- induced testicular damage in rats. Andrologia, 44, 164-173. [CrossRef]
11. Slezak, B.P. (2000). Oxidative Stress in Female B6C3F1 Mice following Acute and Subchronic Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD). Toxicological Sciences, 54(2), 390-398. [CrossRef]
12. Karabacak, K., Kaya, E., Ulusoy, K.G., Seyrek, M., Kurtoglu, M., Doganci, S., Yildirim, V., Yildiz, O., Demirkilic, U. (2015). Effects of taurine on contractions of human internal mammary artery: A potassium channel opening action. European Review for Medical and Pharmacological Sciences, 19(8), 1498-1504.
13. Shimada, K., Jong, C.J., Takahashi, K., Schaffer, S.W. (2015). Role of ROS production and turnover in the antioxidant activity of taurine. Advances in Experimental Medicine and Biology, 803, 581-596. [CrossRef]
14. Yang, S., Liu, L., Meng, L., Hu, X. (2019). Capsaicin is beneficial to hyperlipidemia, oxidative stress, endothelial dysfunction, and atherosclerosis in Guinea pigs fed on a high-fat diet. Chemico-Biological Interactions, 297, 1-7. [CrossRef]
15. Rahman, Q., Abidi, P., Afaq, F., Schiffmann, D., Mossman, B.T., Kamp, D.W., Athar, M. (1999). Glutathione redox system in oxidative lung injury. Critical Reviews in Toxicology, 29(6), 543-568. [CrossRef]
16. Goc, Z., Kapusta, E., Formicki, G., Martiniaková, M., Omelka, R. (2019). Effect of taurine on ethanol-induced oxidative stress in mouse liver and kidney. The Chinese Journal of Physiology, 62(4), 148-156. [CrossRef]
17. Adedara, I.A., Alake, S.E., Adeyemo, M.O., Olajide, L.O., Ajibade, T.O., Farombi, E.O. (2018). Taurine enhances spermatogenic function and antioxidant defense mechanisms in testes and epididymis of L-NAME-induced hypertensive rats. Biomedicine and Pharmacotherapy, 97, 181-189. [CrossRef]
18. Ciftci, O., Ozdemir, I., Tanyildizi, S., Yildiz, S., Oguzturk, H. (2011). Antioxidative effects of curcumin, β-myrcene and 1,8-cineole against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced oxidative stress in rats liver. Toxicology and Industrial Health, 27(5), 447-453. [CrossRef]
19. Ciftci, O., Disli, O.M., Timurkaan, N. (2013). Protective effects of protocatechuic acid on TCDD-induced oxidative and histopathological damage in the heart tissue of rats. Toxicology and Industrial Health, 29(9), 806–811. [CrossRef]
20. Yagi, K. (1998). Simple assay for the level of total lipid peroxides in serum or plasma. Free radical and antioxidant protocols Methods in Molecular Biology, 108, 101-106.
21. Sun, Y.I., Oberley, L.W., Li, Y. (1988). A simple method for clinical assay of superoxide dismutase. Clinical Chemistry, 34(3), 497-500. [CrossRef]
22. Caglayan, C., Kandemir, F.M., Yildirim, S., Kucukler, S., Eser, G. (2019). Rutin protects mercuric chloride‐induced nephrotoxicity via targeting of aquaporin 1 level, oxidative stress, apoptosis and inflammation in rats. Journal of Trace Elements in Medicine and Biology, 54, 69-78. [CrossRef]
23. Pal, G., Behl, T., Rohil, V., Khandelwal, M., Gupta, G., Jena, J. (2020). Evaluation of oxidative stress and its modulation by L-arginine and L-ascorbic acid in repetitive restraint stress model in Wistar rats. Obesity Medicine, 17, 100172. [CrossRef]
24. Hassoun, E.A., Al-Ghafri, M., Abushaban, A. (2003). The role of antioxidant enzymes in TCDD-induced oxidative stress in various brain regions of rats after subchronic exposure. Free Radical Biology and Medicine, 35(9), 1028-1036. [CrossRef]
25. Patrizi, B., Cumis, M.S. (2018). TCDD Toxicity Mediated by Epigenetic Mechanisms. International Journal of Molecular Sciences, 19, 1-15. [CrossRef]
26. Fernandez-Salguero, P.M., Hllbert, D.M., Rudikoff, S., Ward, J.M., Gonzalez, F.J. (1996). Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity. Toxicology and Applied Pharmacology, 140(1), 173-179. [CrossRef]
27. Baliou, S., Adamaki, M., Ioannou, P., Pappa, A., Panayiotidis, M.I., Spandidos, D.A., Christodoulou, I., Kyriakopoulos, A.M., Zoumpourlis, V. (2021). Protective role of taurine against oxidative stress (Review). Molecular Medicine Reports, 24(2), 605. [CrossRef]
28. Doğan, M.F., Başak Türkmen, N., Taşlıdere, A., Şahin, Y., Çiftçi, O. (2021). The protective effects of capsaicin on oxidative damage-induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats. Drug and Chemical Toxicology, 45(6), 2463-2470. [CrossRef]
29. Farombi, E.O., Adedara, I.A., Ebokaiwe, A.P., Teberen, R., Ehwerhemuepha, T. (2010). Nigerian Bonny Light Crude Oil Disrupts Antioxidant Systems in Testes and Sperm of Rats. Archives of Environmental Contamination and Toxicology, 59, 166-174. [CrossRef]
30. Montjean, D., Ménézo, Y., Benkhalifa, M., Cohen, M., Belloc, S., Cohen-Bacrie, P., De Mouzon, J. (2010). Malonaldehyde formation and DNA fragmentation: two independent sperm decays linked to reactive oxygen species. Zygote, 18(3), 265-268. [CrossRef]
31. Jang, H.J., Kim, S.J. (2013). Taurine exerts anti-osteoclastogenesis activity via inhibiting ROS generation, JNK phosphorylation and COX-2 expression in RAW264.7 cells. Journal of Receptors and Signal Transduction, 33(6), 387-391. [CrossRef]
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There are 41 citations in total.

Details

Primary Language	English
Subjects	Pharmacology and Pharmaceutical Sciences
Journal Section	Research Article
Authors	Muhammed Fatih Doğan 0000-0003-4628-2771 Osman Çiftçi 0000-0001-5755-3560 Neşe Başak Türkmen 0000-0001-5566-8321 Aslı Çetin 0000-0003-3902-3210 Münevver Nazlıcan Zengin 0000-0002-3536-6606 Bedriye Çiftçi 0000-0001-5197-6140
Submission Date	March 11, 2022
Acceptance Date	January 27, 2023
Early Pub Date	May 17, 2023
Publication Date	May 20, 2023
DOI	https://doi.org/10.33483/jfpau.1085253
IZ	https://izlik.org/JA28MB54JC
Published in Issue	Year 2023 Volume: 47 Issue: 2

Cite

APA	Doğan, M. F., Çiftçi, O., Başak Türkmen, N., Çetin, A., Zengin, M. N., & Çiftçi, B. (2023). TAURINE PREVENTS AGAINST 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN-INDUCED OXIDATIVE STRESS IN THE LIVER AND KIDNEY OF RATS. Journal of Faculty of Pharmacy of Ankara University, 47(2), 394-407. https://doi.org/10.33483/jfpau.1085253
AMA	1.Doğan MF, Çiftçi O, Başak Türkmen N, Çetin A, Zengin MN, Çiftçi B. TAURINE PREVENTS AGAINST 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN-INDUCED OXIDATIVE STRESS IN THE LIVER AND KIDNEY OF RATS. J. Fac. Pharm. Ankara. 2023;47(2):394-407. doi:10.33483/jfpau.1085253
Chicago	Doğan, Muhammed Fatih, Osman Çiftçi, Neşe Başak Türkmen, Aslı Çetin, Münevver Nazlıcan Zengin, and Bedriye Çiftçi. 2023. “TAURINE PREVENTS AGAINST 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN-INDUCED OXIDATIVE STRESS IN THE LIVER AND KIDNEY OF RATS”. Journal of Faculty of Pharmacy of Ankara University 47 (2): 394-407. https://doi.org/10.33483/jfpau.1085253.
EndNote	Doğan MF, Çiftçi O, Başak Türkmen N, Çetin A, Zengin MN, Çiftçi B (May 1, 2023) TAURINE PREVENTS AGAINST 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN-INDUCED OXIDATIVE STRESS IN THE LIVER AND KIDNEY OF RATS. Journal of Faculty of Pharmacy of Ankara University 47 2 394–407.
IEEE	[1]M. F. Doğan, O. Çiftçi, N. Başak Türkmen, A. Çetin, M. N. Zengin, and B. Çiftçi, “TAURINE PREVENTS AGAINST 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN-INDUCED OXIDATIVE STRESS IN THE LIVER AND KIDNEY OF RATS”, J. Fac. Pharm. Ankara, vol. 47, no. 2, pp. 394–407, May 2023, doi: 10.33483/jfpau.1085253.
ISNAD	Doğan, Muhammed Fatih - Çiftçi, Osman - Başak Türkmen, Neşe - Çetin, Aslı - Zengin, Münevver Nazlıcan - Çiftçi, Bedriye. “TAURINE PREVENTS AGAINST 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN-INDUCED OXIDATIVE STRESS IN THE LIVER AND KIDNEY OF RATS”. Journal of Faculty of Pharmacy of Ankara University 47/2 (May 1, 2023): 394-407. https://doi.org/10.33483/jfpau.1085253.
JAMA	1.Doğan MF, Çiftçi O, Başak Türkmen N, Çetin A, Zengin MN, Çiftçi B. TAURINE PREVENTS AGAINST 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN-INDUCED OXIDATIVE STRESS IN THE LIVER AND KIDNEY OF RATS. J. Fac. Pharm. Ankara. 2023;47:394–407.
MLA	Doğan, Muhammed Fatih, et al. “TAURINE PREVENTS AGAINST 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN-INDUCED OXIDATIVE STRESS IN THE LIVER AND KIDNEY OF RATS”. Journal of Faculty of Pharmacy of Ankara University, vol. 47, no. 2, May 2023, pp. 394-07, doi:10.33483/jfpau.1085253.
Vancouver	1.Doğan MF, Çiftçi O, Başak Türkmen N, Çetin A, Zengin MN, Çiftçi B. TAURINE PREVENTS AGAINST 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN-INDUCED OXIDATIVE STRESS IN THE LIVER AND KIDNEY OF RATS. J. Fac. Pharm. Ankara [Internet]. 2023 May 1;47(2):394-407. Available from: https://izlik.org/JA28MB54JC

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Scope and Aim

The Journal of Faculty of Pharmacy of Ankara University is an international medium, an open access, peer-reviewed journal for the publication of original research reports, reviews and short communications in English or Turkish on relevant developments in pharmaceutical sciences., Proceeding of scientific meetings may be published as special issues of supplements to the journal. Additionally, it contains previous and forthcoming national and international scientific meetings with social activities in pharmaceutical areas.