LOKALİZE MEME KANSERİ TEDAVİLERİNDE EFEKTİF İLAÇ TAŞIYICI SİSTEMLER: ENJEKTABL HİDROJELLER

Year 2024, , 274 - 288, 20.01.2024

Süheyl Furkan Konca , Umut Can Öz , Asuman Bozkır

https://doi.org/10.33483/jfpau.1348607

Abstract

Amaç: Meme kanseri dünya genelinde kadınlarda en sık gözlenen kanser türü olup, erken teşhis ve etkili tedavi stratejilerinin geliştirilmesi için sürekli araştırmaların yapılmasını gerektiren kritik bir sağlık sorunudur. Geleneksel kemoterapi uygulamalarındaki spesifik olmayan hedefleme, sistemik toksisite, ilaç direnci, kısıtlı ilaç penetrasyonu gibi sınırlamaların aşılmasında yenilikçi tedavi yöntemlerinin geliştirilmesine ihtiyaç duyulmaktadır. İlaç taşıyıcı sistemler olarak enjektabl hidrojeller biyoparçalanır, biyouyumlu, tasarıma yönelik ayarlanabilir fizikokimyasal özelliklerinin yanı sıra etkin maddenin yüksek verimlilikte yüklenmesini ve salımını sağlayabilmesi dolayısıyla lokal kanser tedavilerinde ön plana çıkmaktadır. Enjektabl biyoparçalanır hidrojeller özellikle cerrahi sonrası tedavi sürecinde tümör nüksünü ve metastazını önlemede kritik öneme sahiptir. Bu derlemede enjektabl hidrojellerin yapıları, türleri, kanser tedavilerine ilişkin uygulamaları ve antikanser tedavi etkinliklerinin değerlendirilmesi amaçlanmıştır.
Sonuç ve Tartışma: Bu derlemede farmasötik ilaç taşıyıcı sistemler olarak enjektabl hidrojel yapıları, meme kanseri tedavilerine ilişkin uygulamaları ve meme kanserine yönelik antikanser tedavi etkinlikleri ele alınmıştır.

Keywords

Enjektabl hidrojel, ilaç taşıyıcı sistem, lokal tedavi, meme kanseri

EFFECTIVE DRUG DELIVERY SYSTEMS IN LOCALIZED BREAST CANCER THERAPIES: INJECTABLE HYDROGELS

Abstract

Objective: Breast cancer is the most common cancer in women worldwide and is a critical health problem that requires continuous research for early detection and development of effective treatment strategies. There is a need to develop innovative treatment modalities to overcome the limitations of conventional chemotherapy such as non-specific targeting, systemic toxicity, drug resistance and limited drug penetration. As drug delivery systems, injectable hydrogels have come to the forefront in local cancer treatments due to their biodegradable, biocompatible, design-adjustable physicochemical properties as well as their ability to provide highly efficient loading and release of the active substance. Injectable biodegradable hydrogels are critical in preventing cancer
recurrence and metastasis, especially in the post surgical treatment process. In this review, we aimed to evaluate the structures, types, cancer treatment applications and anticancer therapeutic efficacy of injectable hydrogels.
Result and Discussion: In this review, the structures of injectable hydrogels as pharmaceutical drug delivery systems, their applications in breast cancer treatments and their anticancer therapeutic efficacy for breast cancer were discussed.

Keywords

Breast cancer, drug delivery system, injectable hydrogel, local therapy

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