CHEMICAL COMPOSITION AND BIOACTIVITIES OF ESSENTIAL OIL FROM AN ENDEMIC SALVIA ABSCONDITIFLORA GREUTER & BURDET

Ahsen Sevde Çınar; Suna Sibel Rızvanoğlu; Müjde Eryılmaz; Betül Demirci; Alev Önder

doi:10.33483/jfpau.1416623

Research Article

CHEMICAL COMPOSITION AND BIOACTIVITIES OF ESSENTIAL OIL FROM AN ENDEMIC SALVIA ABSCONDITIFLORA GREUTER & BURDET

Year 2024, Volume: 48 Issue: 2, 586 - 596, 20.05.2024

Ahsen Sevde Çınar , Suna Sibel Rızvanoğlu , Müjde Eryılmaz , Betül Demirci , Alev Önder

https://doi.org/10.33483/jfpau.1416623

Cited By: 2

Abstract

Objective: The study aimed to determine the chemical composition and antibacterial, antibiofilm, and anti-quorum sensing activities of the essential oil of Salvia absconditiflora Greuter & Burdet (an endemic species) growing wildly in Türkiye.
Material and Method: The essential oil from the aerial parts of the plant was obtained by hydro-distillation (0.4%) and analyzed by GC-FID and GC-MS. In addition, the broth microdilution method was used to determine antibacterial activity. The crystal violet assay was performed for antibiofilm activity, and the reporter bacteria Chromobacterium violaceum ATCC 12472 was used in the anti-quorum sensing activity test.
Result and Discussion: The major components of the essential oil were identified as 1,8-cineole (32.2%), camphor (13.6%), α-pinene (7.6%), camphene (5.5%), and viridiflorol (5.1%). The essential oil showed the best antibacterial activity against Gram-positive test bacteria, with a minimum inhibitory concentration (MIC) of 0.0078 (v/v) against Staphylococcus aureus strains. The percentage biofilm inhibition value of the essential oil was determined as 84.4%. The inhibition of violacein production by the essential oil in Chromobacterium violaceum ATCC 12472 indicated the possibility of anti-quorum sensing activity. The results of this study show that the essential oil of S. absconditiflora could be a promising alternative in fighting bacterial infections.

Keywords

Antibacterial activity , antibiofilm activity , anti-quorum sensing activity , essential oil , Lamiaceae , Salvia absconditiflora

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ENDEMİK SALVIA ABSCONDITIFLORA GREUTER & BURDET UÇUCU YAĞININ KİMYASAL İÇERİĞİ VE BİYOAKTİVİTELERİ

Year 2024, Volume: 48 Issue: 2, 586 - 596, 20.05.2024

Ahsen Sevde Çınar , Suna Sibel Rızvanoğlu , Müjde Eryılmaz , Betül Demirci , Alev Önder

https://doi.org/10.33483/jfpau.1416623

Cited By: 2

Abstract

Amaç: Bu calışma, Türkiye'de doğal olarak yetişen Salvia absconditiflora Greuter & Burdet (endemik) uçucu yağının kimyasal bileşimini ve antibakteriyel, antibiyofilm ve anti-quorum sensing aktivitelerini belirlemeyi amaçlamıştır.
Gereç ve Yöntem: Bitkinin toprak üstü kısımlarından su distilasyonu yöntemi ile elde edilen uçucu yağın verimi (%0.4) belirlenmiş, GC-FID ve GC-MS cihazları ile kimyasal içeriği tayin edilmiştir. Ayrıca S. absconditiflora'dan elde edilen uçucu yağın antibakteriyel aktivitesi mikrodilüsyon yöntemi ile belirlenmiştir. Antibiyofilm aktivite için kristal viyole yöntemi ve anti-quorum sensing aktivite için raportör bakteri Chromobacterium violaceum ATCC 12472 kullanılmıştır.
Sonuç ve Tartışma: Uçucu yağın ana bileşenleri 1,8-sineol (%32.2), kafur (%13.6), α-pinen (%7.6), kamfen (%5.5) ve viridiflorol (%5.1) olarak belirlenmiştir. Uçucu yağ, Gram-pozitif bakterilerine karşı en iyi antibakteriyel aktiviteyi, Staphylococcus aureus suşlarına karşı 0,0078 (h/h) minimum inhibitör konsantrasyonu (MIC) ile göstermiştir. Ayrıca uçucu yağın biyofilm inhibisyon değeri %84.4 olarak belirlenmiştir. Chromobacterium violaceum ATCC 12472 suşunda viyolasin üretiminin engellenmesi de, olası anti-quorum sensing aktivitesinin varlığını göstermiştir. Yapılan çalışmaların sonucunda, S. absconditiflora uçucu yağının bakteriyel enfeksiyonlarla mücadelede umut verici bir alternatif olabileceği belirlenmiştir.

Keywords

Antibakteriyel aktivite , antibiyofilm aktivite , anti-quorum sensing aktivite , Lamiaceae , Salvia absconditiflora , uçucu yağ

References

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32. Eryılmaz, M., Kart, D., Gürpınar, S.S. (2019). Vajinal floradan izole edilen Lactobacillus sp. metabolitlerinin antibiyofilm aktivitelerinin araştırılması. Türk Mikrobiyoloji Cemiyeti Dergisi, 49(3), 169-174.
33. Jardak, M., Mnif, S., Ayed, R.B., Rezgui, F., Aifa, S. (2021). Chemical composition, antibiofilm activities of Tunisian spices essential oils, and combinatorial effect against Staphylococcus epidermidis biofilm. Lebensmittel-Wissenschaft & Technologie, 140, 110691. [CrossRef]
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There are 56 citations in total.

Details

Primary Language	English
Subjects	Pharmacognosy
Journal Section	Research Article
Authors	Ahsen Sevde Çınar 0000-0001-6030-6931 Suna Sibel Rızvanoğlu 0000-0003-4244-0920 Müjde Eryılmaz 0000-0003-3760-1996 Betül Demirci 0000-0003-2343-746X Alev Önder 0000-0002-9088-1045
Submission Date	January 9, 2024
Acceptance Date	March 27, 2024
Early Pub Date	April 24, 2024
Publication Date	May 20, 2024
Published in Issue	Year 2024 Volume: 48 Issue: 2

Cite

APA	Çınar, A. S., Rızvanoğlu, S. S., Eryılmaz, M., Demirci, B., & Önder, A. (2024). CHEMICAL COMPOSITION AND BIOACTIVITIES OF ESSENTIAL OIL FROM AN ENDEMIC SALVIA ABSCONDITIFLORA GREUTER & BURDET. Journal of Faculty of Pharmacy of Ankara University, 48(2), 586-596. https://doi.org/10.33483/jfpau.1416623
AMA	1.Çınar AS, Rızvanoğlu SS, Eryılmaz M, Demirci B, Önder A. CHEMICAL COMPOSITION AND BIOACTIVITIES OF ESSENTIAL OIL FROM AN ENDEMIC SALVIA ABSCONDITIFLORA GREUTER & BURDET. J. Fac. Pharm. Ankara. 2024;48(2):586-596. doi:10.33483/jfpau.1416623
Chicago	Çınar, Ahsen Sevde, Suna Sibel Rızvanoğlu, Müjde Eryılmaz, Betül Demirci, and Alev Önder. 2024. “CHEMICAL COMPOSITION AND BIOACTIVITIES OF ESSENTIAL OIL FROM AN ENDEMIC SALVIA ABSCONDITIFLORA GREUTER & BURDET”. Journal of Faculty of Pharmacy of Ankara University 48 (2): 586-96. https://doi.org/10.33483/jfpau.1416623.
EndNote	Çınar AS, Rızvanoğlu SS, Eryılmaz M, Demirci B, Önder A (May 1, 2024) CHEMICAL COMPOSITION AND BIOACTIVITIES OF ESSENTIAL OIL FROM AN ENDEMIC SALVIA ABSCONDITIFLORA GREUTER & BURDET. Journal of Faculty of Pharmacy of Ankara University 48 2 586–596.
IEEE	[1]A. S. Çınar, S. S. Rızvanoğlu, M. Eryılmaz, B. Demirci, and A. Önder, “CHEMICAL COMPOSITION AND BIOACTIVITIES OF ESSENTIAL OIL FROM AN ENDEMIC SALVIA ABSCONDITIFLORA GREUTER & BURDET”, J. Fac. Pharm. Ankara, vol. 48, no. 2, pp. 586–596, May 2024, doi: 10.33483/jfpau.1416623.
ISNAD	Çınar, Ahsen Sevde - Rızvanoğlu, Suna Sibel - Eryılmaz, Müjde - Demirci, Betül - Önder, Alev. “CHEMICAL COMPOSITION AND BIOACTIVITIES OF ESSENTIAL OIL FROM AN ENDEMIC SALVIA ABSCONDITIFLORA GREUTER & BURDET”. Journal of Faculty of Pharmacy of Ankara University 48/2 (May 1, 2024): 586-596. https://doi.org/10.33483/jfpau.1416623.
JAMA	1.Çınar AS, Rızvanoğlu SS, Eryılmaz M, Demirci B, Önder A. CHEMICAL COMPOSITION AND BIOACTIVITIES OF ESSENTIAL OIL FROM AN ENDEMIC SALVIA ABSCONDITIFLORA GREUTER & BURDET. J. Fac. Pharm. Ankara. 2024;48:586–596.
MLA	Çınar, Ahsen Sevde, et al. “CHEMICAL COMPOSITION AND BIOACTIVITIES OF ESSENTIAL OIL FROM AN ENDEMIC SALVIA ABSCONDITIFLORA GREUTER & BURDET”. Journal of Faculty of Pharmacy of Ankara University, vol. 48, no. 2, May 2024, pp. 586-9, doi:10.33483/jfpau.1416623.
Vancouver	1.Çınar AS, Rızvanoğlu SS, Eryılmaz M, Demirci B, Önder A. CHEMICAL COMPOSITION AND BIOACTIVITIES OF ESSENTIAL OIL FROM AN ENDEMIC SALVIA ABSCONDITIFLORA GREUTER & BURDET. J. Fac. Pharm. Ankara [Internet]. 2024 May 1;48(2):586-9. Available from: https://izlik.org/JA62YZ72LH

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The Journal of Faculty of Pharmacy of Ankara University is an international medium, an open access, peer-reviewed journal for the publication of original research reports, reviews and short communications in English or Turkish on relevant developments in pharmaceutical sciences., Proceeding of scientific meetings may be published as special issues of supplements to the journal. Additionally, it contains previous and forthcoming national and international scientific meetings with social activities in pharmaceutical areas.