OKÜLER İLAÇ TAŞIYICI SİSTEM OLARAK LİPİT BAZLI NANOPARTİKÜLLER

Year 2024, , 751 - 765, 20.05.2024

Heybet Kerem Polat , Eren Aytekin , Nasıf Fatih Karakuyu , Nihat Kurt , Yonca Yazıksız

https://doi.org/10.33483/jfpau.1420064

Abstract

Amaç: Bu derleme kapsamında, oküler kullanımdaki katı lipit nanopartikül (KLN) ve nanoyapılı lipit taşıyıcı (NLT) sistemlerine, bu formülasyonların sterilizasyonuna ve tasarımla kalite (QbD) hakkında yapılan son araştırmaları tartışmak amaçlanmıştır.
Sonuç ve Tartışma: Göze ilaç taşınması son yıllardaki gelişmelere rağmen hala karmaşık bir sorun olarak devem etmekte ve etkili ilaç taşınabilmesi için yenilikçi yaklaşımlara ihtiyaç duyulan bir alandır. Bu derlemede, yenilikçi yaklaşımlardan olan KLN’ler ve NLT’lerin oftalmik ilaç uygulamalarında sağladıkları üstünlükler güncel literatür örnekleriyle tartışılmıştır. KLN’ler oda sıcaklığında katı halde bulunan lipitlerin genellikle eritilmesi ya da çeşitli solvanlarda çözündürülmesi ile hazırlanan lipit partiküllerdir. NLT’ler ise yapısında katı lipitlerle birlikte oda sıcaklığında sıvı halde bulunan lipitleri de içermektedir. Oküler ilaç uygulamalarında kritik aşamalardan biri de sterilizasyon basamağıdır. Uygun sterilizasyon işleminin seçiminde, kullanılan lipitlerin erime dereceleri, serbest radikal oluşturma eğilimleri ve partikül büyüklükleri göz önünde bulundurulmalıdır. Sonuç olarak, KLN ve NLT’ler hem biyouyumluluk hem de etkililik anlamında oküler tedaviler için umut vadeden ilaç taşıyıcı sistemlerdir. Derleme kapsamında incelenen literatür çalışmaları da bu çıkarımı desteklemektedir. Ancak saklama süresince karşılaşılabilen stabilite sorunları ve tekrarlanabilir büyük ölçekte üretim konusunda yaşanan sıkıntılar nedeniyle klinik tedavide yeterince kullanılamamaktadır. Bu sorunların çözümü aşamasında QbD’nin etkili olacağı düşünülmektedir.

Keywords

Göz, katı lipid nanopartiküller, nano yapılı lipit taşıyıcılar, QbD, sterilizasyon

LIPID-BASED NANOPARTICLES AS OCULAR DRUG DELIVERY SYSTEM

Abstract

Objective: Within the scope of this review, it aims to discuss the latest research on solid lipid nanoparticle (KLN) and nanostructured lipid carrier (NLT) systems for ocular use, sterilization of these formulations, and quality by design (QbD).
Result and Discussion: Despite the developments in recent years, drug delivery to the eye remains a complex problem and is an area where innovative approaches are needed for effective drug delivery. This review discusses the advantages of KLNs and NLTs, innovative approaches in ophthalmic drug applications, with examples from current literature. KLNs are lipid particles prepared by melting solid lipids at room temperature or dissolving them in various solvents. NLTs, on the other hand, contain solid lipids in their structure, as well as lipids that are liquid at room temperature. One of the critical stages in ocular drug applications is the sterilization step. In choosing the appropriate sterilization process, the melting degrees, free radical formation tendencies, and particle sizes of the lipids used should be considered. In conclusion, KLNs and NLTs are promising drug delivery systems for ocular treatments in terms of biocompatibility and efficacy. The studies examined within the scope of the review also support this inference. However, it cannot be used adequately in clinical treatment due to stability problems that may be encountered during storage and difficulties in reproducible large-scale production. It is thought that QbD will be effective in solving these problems.

Keywords

Eye, nanostructured lipid carriers, QbD, solid lipid nanoparticles, sterilization

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