ROMATİK HASTALIKLARA YÖNELİK OLEUM ROSMARİNİ BAZLI TOPİKAL EMÜLJEL FORMÜLASYONUNUN GELİŞTİRİLMESİ VE İN VİTRO DEĞERLENDİRİLMESİ

Abstract

Amaç: Bu çalışmada romatoid artrit tedavisinde kullanılmak üzere Oleum rosmarini içeren y/s tipi emülsiyonlardan topikal bir emüljel formülasyonunun geliştirilmesi ve in vitro karakterizasyonu amaçlanmıştır. Gereç ve Yöntem: In vitro formülasyon çalışmaları ile uygun formülasyonun seçilmesi amacıyla farklı polimer konsantrasyonlarında farklı oranlarda yağ, yüzey aktif madde, kopolimer ve plastizer içeren emülsiyon kombinasyonlarında su fazı olarak Carbopol 996 ve HPMC, yağ fazı olarak Oleum rosmarini kullanılmıştır. Seçilen formülasyonların organoleptik kontrolleri yapılmış ve pH, tekstür profili analizi, reoloji değerlendirmesi ve termodinamik stabilite açısından karakterizasyonları gerçekleştirilmiştir. Sonuç ve Tartışma: Optimize edilen krem formülasyonların pH değeri 5.5-6.5 aralığında olup, formülasyonlar homojen bir şekilde elde edilmiş ve herhangi bir faz ayrımı gözlenmemiştir. Emüljellerin topikal uygulama için uygun viskozite, akış özellikleri, mekanik özellikler gösterdiği ve yüksek termodinamik stabiliteye sahip olduğu belirlenmiştir.

Keywords

• Esansiyel yağ
• romatoid artrit
• Rosmarinus officinalis
• topikal emüljel

DEVELOPMENT AND IN VITRO EVALUATION OF OLEUM ROSMARINI BASED TOPICAL EMULGEL FORMULATION FOR RHEUMATIC DISEASE

Abstract

Objective: In this study, it was aimed to develop a topical emulgel formulation from o/w type emulsions containing Oleum rosmarini, to be used in the treatment of rheumatoid arthritis. Material and Method: Carbopol 996 and HPMC were used as the water phase and Oleum rosmarini was used as oil phase in the emulsion combinations containing oil, surfactant, copolymer and plasticizer at different rates over different polymer concentrations, to select the appropriate formulation with in vitro formulation studies. Organoleptic controls of the selected formulations were made and characterizations were made in terms of pH, texture profile analysis, rheology evaluation and thermodynamic stability. Result and Discussion: The pH value of the optimized formulations was in the range of 5.5-6.5. The formulations were obtained homogeneously, and no phase separation was observed. It has been observed that the emulgels provide suitable viscosity, flow properties, mechanical properties and have high stability for topical application.

Keywords

• Essential oil
• rheumatoid arthritis
• Rosmarinus officinalis
• topical emulgel

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