CURRENT TECHNOLOGIES IN WOUND DRESSINGS AND PHARMACEUTICAL CHARACTERIZATION METHODS

Abstract

Objective: This review aims to evaluate studies on wound dressings by comparatively analyzing wound care principles, ideal wound dressing properties, classifications of wound dressings, preparation methods, and characterization studies of wound dressings. Additionally, it seeks to investigate the latest technologies in wound dressing production. Result and Discussion: An ideal wound dressing must meet the fundamental principles of wound care. Numerous studies have been performed from past to present to facilitate and accelerate the wound healing process. With the advancement of modern technologies, traditional wound dressings such as gauze have been replaced by modern wound dressings made from natural and synthetic polymers or their combinations. Modern polymer-based wound dressings enable the development of products that can carry drugs facilitating and accelerating wound healing and can be adapted into various physical forms. In this review, modern wound dressings are classified into films and hydrogels, nanofibers, foams and sponges, composites and scaffolds, bioactive wound dressings, and biological wound dressings. Preparation methods, advantages, disadvantages, and examples of approved market preparations are discussed. The characterization studies of wound dressings regarding their stability and efficacy are also evaluated. As a result of our studies on the subject, although a single ideal wound dressing suitable for different wound types cannot be identified, it has been determined that mass-produced therapeutic systems can be customized where wound dressings can be prepared according to the size of patient-specific chronic wounds thanks to the use of technologies that can almost exactly mimic the skin such as 3D printing, nanofiber technologies, or use of sprayable-particulate wound dressing systems.

Keywords

• Biomaterial
• polymeric drug delivery systems
• wound healing
• wound dressing
• wound management
• in vitro characterization

Project Number

121R076 TÜBİTAK 1001

YARA ÖRTÜLERİNDE GÜNCEL TEKNOLOJİLER VE FARMASÖTİK KARAKTERİZASYON YÖNTEMLERİ

Abstract

Amaç: Bu derlemede yara örtüsü üzerine yapılan çalışmalar incelenerek yara bakım prensipleri, ideal yara örtüsü özellikleri, yara örtülerinin sınıflandırmaları, hazırlanma yöntemleri ve yara örtülerinde yapılan karakterizasyon çalışmaları karşılaştırmalı olarak değerlendirerek en güncel yara örtüsü üretim teknolojilerinin araştırılması amaçlanmıştır. Sonuç ve Tartışma: İdeal bir yara örtüsü temel yara bakım prensiplerini karşılamalıdır. Yara iyileşme sürecini kolaylaştırmak ve hızlandırmak için geçmişten günümüze dek pek çok çalışma yapılmıştır. Günümüzde modern teknolojilerin gelişmesiyle birlikte, gazlı bezler gibi geleneksel örtüler yerine doğal ve sentetik polimerler ve bunların kombinasyonlarından oluşan modern yara örtüleri kullanılmaya başlamıştır. Temeli polimerlere dayanan modern yara örtüleri sayesinde, bünyesinde yara iyileşmesini kolaylaştıran ve hızlandıran etkin maddeleri taşıyabilen ve farklı fiziksel formlarda uyarlanabilen yara örtüleri geliştirilmiştir. Bu derlemede modern yara örtüleri filmler ve hidrojeller, nanolifler, köpükler ve süngerler, kompozitler ve iskeleler, biyoaktif yara örtüleri ve biyolojik yara örtüleri olarak sınıflandırılmıştır. Hazırlama yöntemleri, çeşitli avantajları ve dezavantajları, onaylı piyasa preparatlarından örnekler verilerek açıklanmıştır. Hem stabilite hem etkinlik açısından yara örtülerinden beklenen özelliklerin karakterizasyon çalışmaları değerlendirilmiştir. Konuyla ilgili incelemelerimiz sonucunda, farklı yara türlerine uygun ideal tek bir yara örtüsünden bahsedilemese de özellikle hastaya özgü kronik yaraların boyutuna uygun yara örtülerinin hazırlanabildiği 3B baskı, nanolif teknolojileri gibi deriyi neredeyse birebir taklit edebilen teknolojilerin veya püskürtülebilir-partiküler yara örtüsü sistemlerinin kullanımı sayesinde kitlesel olarak üretilen terapötik sistemlerin kişiye özel hale getirilebileceği tespit edilmiştir.

Keywords

• Biyomateryal
• polimerik ilaç taşıyıcı sistemler
• yara iyileşmesi
• yara örtüsü
• yara yönetimi
• in vitro karakterizasyon

Supporting Institution

TÜBİTAK

Project Number

121R076 TÜBİTAK 1001

Thanks

Bu çalışma, 121R076 nolu TÜBİTAK-1001 projesi ile desteklenen birinci yazarın ikinci yazar danışmanlığında hazırladığı doktora tezi çalışmasından üretilmiştir.

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