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The inhibitory effects of thiazolyl-2,4 thiazolidinedione compounds on the rat kidney aldose reductase enzyme

Year 2009, , 181 - 190, 01.09.2009

Meltem Ceylan Ünlüsoy Net Das Evcimen Mutlu Sarıkaya Oya Bozdağ Dündar Rahmiye Ertan

https://doi.org/10.1501/Eczfak_0000000526

Abstract

Aldoz redüktaz enzimi glukozun sorbitole indirgenmesi reaksiyonunda anahtar rol oynamaktadır. Sorbitolün birikimi diyabette, diyabetik katarakt, retinopati, nöropati ve nefropati gibi komplikasyonlara neden olmaktadır. Aldoz redüktaz inhibitörlerinin dokularda sorbitol birikimini önlediği gösterilmiştir. Aldoz redüktaz enziminin inhibisyonunun farmakolojik profilini geliştirmek amacı ile çok sayıda bileşik geliştirilmiştir. Bu çalışmada, tiyazolil-2,4-tiyazolidindion serilerinin (Ia-f, IIa-f and IIIa-f) aldoz redüktaz inhibitör aktiviteleri test edilmiştir. Substitüe-tiyazolil-tiyazolidindion türevlerinin çok az düzeyde inhibitör aktiviteleri olduğu tespit edilmiştir

Keywords

2 4-Tiyazolidindionlar Tiyazol Türevleri Aldoz Redüktaz Enzimi İnhibisyon Diyabet

THE INHIBITORY EFFECTS OF THIAZOLYL-2,4- THIAZOLIDINEDIONE COMPOUNDS ON THE RAT KIDNEY ALDOSE REDUCTASE ENZYME

Year 2009, , 181 - 190, 01.09.2009

Meltem Ceylan Ünlüsoy Net Das Evcimen Mutlu Sarıkaya Oya Bozdağ Dündar Rahmiye Ertan

https://doi.org/10.1501/Eczfak_0000000526

Abstract

Aldose reductase enzyme is the key factor in the reduction of glucose to sorbitol. Accumulation of sorbitol in diabetes causes complications such as diabetic cataract, retinopathy, neuropathy and nephropathy. Aldose reductase inhibitors have been found to prevent sorbitol accumulation in tissues. Numerous compounds have been prepared in order to improve the pharmacological profile of inhibition of aldose reductase enzyme. In this study, series of thiazolyl-2,4-thiazolidinediones (Ia-f, IIa-f and IIIa-f) were tested for their aldose reductase inhibitory activities. It was found that substituted-thiazolyl-thiazolidinedione derivatives showing very slight inhibitor activity

Keywords

2 4-Thiazolidinediones Thiazole derivatives Aldose reductase enzyme Inhibition Diabetes

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Details

Other ID JA95FP28MN
Journal Section Research Article
Authors

Meltem Ceylan Ünlüsoy This is me

Net Das Evcimen This is me

Mutlu Sarıkaya This is me

Oya Bozdağ Dündar This is me

Rahmiye Ertan This is me

Publication Date September 1, 2009
Submission Date September 1, 2009
Published in Issue Year 2009

Cite

APA Ceylan Ünlüsoy, M., Das Evcimen, N., Sarıkaya, M., Bozdağ Dündar, O., et al. (2009). THE INHIBITORY EFFECTS OF THIAZOLYL-2,4- THIAZOLIDINEDIONE COMPOUNDS ON THE RAT KIDNEY ALDOSE REDUCTASE ENZYME. Journal of Faculty of Pharmacy of Ankara University, 38(3), 181-190. https://doi.org/10.1501/Eczfak_0000000526
AMA Ceylan Ünlüsoy M, Das Evcimen N, Sarıkaya M, Bozdağ Dündar O, Ertan R. THE INHIBITORY EFFECTS OF THIAZOLYL-2,4- THIAZOLIDINEDIONE COMPOUNDS ON THE RAT KIDNEY ALDOSE REDUCTASE ENZYME. Ankara Ecz. Fak. Derg. September 2009;38(3):181-190. doi:10.1501/Eczfak_0000000526
Chicago Ceylan Ünlüsoy, Meltem, Net Das Evcimen, Mutlu Sarıkaya, Oya Bozdağ Dündar, and Rahmiye Ertan. “THE INHIBITORY EFFECTS OF THIAZOLYL-2,4- THIAZOLIDINEDIONE COMPOUNDS ON THE RAT KIDNEY ALDOSE REDUCTASE ENZYME”. Journal of Faculty of Pharmacy of Ankara University 38, no. 3 (September 2009): 181-90. https://doi.org/10.1501/Eczfak_0000000526.
EndNote Ceylan Ünlüsoy M, Das Evcimen N, Sarıkaya M, Bozdağ Dündar O, Ertan R (September 1, 2009) THE INHIBITORY EFFECTS OF THIAZOLYL-2,4- THIAZOLIDINEDIONE COMPOUNDS ON THE RAT KIDNEY ALDOSE REDUCTASE ENZYME. Journal of Faculty of Pharmacy of Ankara University 38 3 181–190.
IEEE M. Ceylan Ünlüsoy, N. Das Evcimen, M. Sarıkaya, O. Bozdağ Dündar, and R. Ertan, “THE INHIBITORY EFFECTS OF THIAZOLYL-2,4- THIAZOLIDINEDIONE COMPOUNDS ON THE RAT KIDNEY ALDOSE REDUCTASE ENZYME”, Ankara Ecz. Fak. Derg., vol. 38, no. 3, pp. 181–190, 2009, doi: 10.1501/Eczfak_0000000526.
ISNAD Ceylan Ünlüsoy, Meltem et al. “THE INHIBITORY EFFECTS OF THIAZOLYL-2,4- THIAZOLIDINEDIONE COMPOUNDS ON THE RAT KIDNEY ALDOSE REDUCTASE ENZYME”. Journal of Faculty of Pharmacy of Ankara University 38/3 (September 2009), 181-190. https://doi.org/10.1501/Eczfak_0000000526.
JAMA Ceylan Ünlüsoy M, Das Evcimen N, Sarıkaya M, Bozdağ Dündar O, Ertan R. THE INHIBITORY EFFECTS OF THIAZOLYL-2,4- THIAZOLIDINEDIONE COMPOUNDS ON THE RAT KIDNEY ALDOSE REDUCTASE ENZYME. Ankara Ecz. Fak. Derg. 2009;38:181–190.
MLA Ceylan Ünlüsoy, Meltem et al. “THE INHIBITORY EFFECTS OF THIAZOLYL-2,4- THIAZOLIDINEDIONE COMPOUNDS ON THE RAT KIDNEY ALDOSE REDUCTASE ENZYME”. Journal of Faculty of Pharmacy of Ankara University, vol. 38, no. 3, 2009, pp. 181-90, doi:10.1501/Eczfak_0000000526.
Vancouver Ceylan Ünlüsoy M, Das Evcimen N, Sarıkaya M, Bozdağ Dündar O, Ertan R. THE INHIBITORY EFFECTS OF THIAZOLYL-2,4- THIAZOLIDINEDIONE COMPOUNDS ON THE RAT KIDNEY ALDOSE REDUCTASE ENZYME. Ankara Ecz. Fak. Derg. 2009;38(3):181-90.

Kapsam ve Amaç

Ankara Üniversitesi Eczacılık Fakültesi Dergisi, açık erişim, hakemli bir dergi olup Türkçe veya İngilizce olarak farmasötik bilimler alanındaki önemli gelişmeleri içeren orijinal araştırmalar, derlemeler ve kısa bildiriler için uluslararası bir yayım ortamıdır. Bilimsel toplantılarda sunulan bildiriler supleman özel sayısı olarak dergide yayımlanabilir. Ayrıca, tüm farmasötik alandaki gelecek ve önceki ulusal ve uluslararası bilimsel toplantılar ile sosyal aktiviteleri içerir.