THE INHIBITORY EFFECTS OF THIAZOLYL-2,4- THIAZOLIDINEDIONE COMPOUNDS ON THE RAT KIDNEY ALDOSE REDUCTASE ENZYME

Meltem Ceylan Ünlüsoy; Net Das Evcimen; Mutlu Sarıkaya; Oya Bozdağ Dündar; Rahmiye Ertan

doi:10.1501/Eczfak_0000000526

TR EN

The inhibitory effects of thiazolyl-2,4 thiazolidinedione compounds on the rat kidney aldose reductase enzyme

Abstract

Aldoz redüktaz enzimi glukozun sorbitole indirgenmesi reaksiyonunda anahtar rol oynamaktadır. Sorbitolün birikimi diyabette, diyabetik katarakt, retinopati, nöropati ve nefropati gibi komplikasyonlara neden olmaktadır. Aldoz redüktaz inhibitörlerinin dokularda sorbitol birikimini önlediği gösterilmiştir. Aldoz redüktaz enziminin inhibisyonunun farmakolojik profilini geliştirmek amacı ile çok sayıda bileşik geliştirilmiştir. Bu çalışmada, tiyazolil-2,4-tiyazolidindion serilerinin (Ia-f, IIa-f and IIIa-f) aldoz redüktaz inhibitör aktiviteleri test edilmiştir. Substitüe-tiyazolil-tiyazolidindion türevlerinin çok az düzeyde inhibitör aktiviteleri olduğu tespit edilmiştir

Keywords

2,4-Tiyazolidindionlar, Tiyazol Türevleri, Aldoz Redüktaz Enzimi, İnhibisyon, Diyabet

Details

Primary Language

English

Subjects

-

Journal Section

-

Authors

Meltem Ceylan Ünlüsoy This is me

Net Das Evcimen This is me

Mutlu Sarıkaya This is me

Oya Bozdağ Dündar This is me

Rahmiye Ertan This is me

Publication Date

September 1, 2009

Submission Date

September 1, 2009

Acceptance Date

-

Published in Issue

Year 2009 Volume: 38 Number: 3

DOI

https://doi.org/10.1501/Eczfak_0000000526

IZ

https://izlik.org/JA22SW89YD

Cite

RIS / Bibtex

APA

Ceylan Ünlüsoy, M., Das Evcimen, N., Sarıkaya, M., Bozdağ Dündar, O., & Ertan, R. (2009). THE INHIBITORY EFFECTS OF THIAZOLYL-2,4- THIAZOLIDINEDIONE COMPOUNDS ON THE RAT KIDNEY ALDOSE REDUCTASE ENZYME. Journal of Faculty of Pharmacy of Ankara University, 38(3), 181-190. https://doi.org/10.1501/Eczfak_0000000526

AMA

1.Ceylan Ünlüsoy M, Das Evcimen N, Sarıkaya M, Bozdağ Dündar O, Ertan R. THE INHIBITORY EFFECTS OF THIAZOLYL-2,4- THIAZOLIDINEDIONE COMPOUNDS ON THE RAT KIDNEY ALDOSE REDUCTASE ENZYME. J. Fac. Pharm. Ankara. 2009;38(3):181-190. doi:10.1501/Eczfak_0000000526

Chicago

Ceylan Ünlüsoy, Meltem, Net Das Evcimen, Mutlu Sarıkaya, Oya Bozdağ Dündar, and Rahmiye Ertan. 2009. “THE INHIBITORY EFFECTS OF THIAZOLYL-2,4- THIAZOLIDINEDIONE COMPOUNDS ON THE RAT KIDNEY ALDOSE REDUCTASE ENZYME”. Journal of Faculty of Pharmacy of Ankara University 38 (3): 181-90. https://doi.org/10.1501/Eczfak_0000000526.

EndNote

Ceylan Ünlüsoy M, Das Evcimen N, Sarıkaya M, Bozdağ Dündar O, Ertan R (September 1, 2009) THE INHIBITORY EFFECTS OF THIAZOLYL-2,4- THIAZOLIDINEDIONE COMPOUNDS ON THE RAT KIDNEY ALDOSE REDUCTASE ENZYME. Journal of Faculty of Pharmacy of Ankara University 38 3 181–190.

IEEE

[1]M. Ceylan Ünlüsoy, N. Das Evcimen, M. Sarıkaya, O. Bozdağ Dündar, and R. Ertan, “THE INHIBITORY EFFECTS OF THIAZOLYL-2,4- THIAZOLIDINEDIONE COMPOUNDS ON THE RAT KIDNEY ALDOSE REDUCTASE ENZYME”, J. Fac. Pharm. Ankara, vol. 38, no. 3, pp. 181–190, Sept. 2009, doi: 10.1501/Eczfak_0000000526.

ISNAD

Ceylan Ünlüsoy, Meltem - Das Evcimen, Net - Sarıkaya, Mutlu - Bozdağ Dündar, Oya - Ertan, Rahmiye. “THE INHIBITORY EFFECTS OF THIAZOLYL-2,4- THIAZOLIDINEDIONE COMPOUNDS ON THE RAT KIDNEY ALDOSE REDUCTASE ENZYME”. Journal of Faculty of Pharmacy of Ankara University 38/3 (September 1, 2009): 181-190. https://doi.org/10.1501/Eczfak_0000000526.

JAMA

1.Ceylan Ünlüsoy M, Das Evcimen N, Sarıkaya M, Bozdağ Dündar O, Ertan R. THE INHIBITORY EFFECTS OF THIAZOLYL-2,4- THIAZOLIDINEDIONE COMPOUNDS ON THE RAT KIDNEY ALDOSE REDUCTASE ENZYME. J. Fac. Pharm. Ankara. 2009;38:181–190.

MLA

Ceylan Ünlüsoy, Meltem, et al. “THE INHIBITORY EFFECTS OF THIAZOLYL-2,4- THIAZOLIDINEDIONE COMPOUNDS ON THE RAT KIDNEY ALDOSE REDUCTASE ENZYME”. Journal of Faculty of Pharmacy of Ankara University, vol. 38, no. 3, Sept. 2009, pp. 181-90, doi:10.1501/Eczfak_0000000526.

Vancouver

1.Meltem Ceylan Ünlüsoy, Net Das Evcimen, Mutlu Sarıkaya, Oya Bozdağ Dündar, Rahmiye Ertan. THE INHIBITORY EFFECTS OF THIAZOLYL-2,4- THIAZOLIDINEDIONE COMPOUNDS ON THE RAT KIDNEY ALDOSE REDUCTASE ENZYME. J. Fac. Pharm. Ankara. 2009 Sep. 1;38(3):181-90. doi:10.1501/Eczfak_0000000526

The inhibitory effects of thiazolyl-2,4 thiazolidinedione compounds on the rat kidney aldose reductase enzyme

Abstract

Keywords

THE INHIBITORY EFFECTS OF THIAZOLYL-2,4- THIAZOLIDINEDIONE COMPOUNDS ON THE RAT KIDNEY ALDOSE REDUCTASE ENZYME

Abstract

Keywords

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

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Acceptance Date

Published in Issue

DOI

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