MICRONUCLEUS LEVELS AND SISTER CHROMATIDE EXCHANGE FREQUENCIES IN BORON EXPOSED AND CONTROL INDIVIDUALS

Zuhal Uçkun; Aylin Üstündağ; Mehmet Korkmaz; Yalçın Duydu

doi:10.1501/Eczfak_0000000518

Micronucleus levels and sister chromatide exchange frequencies in boron exposed and control individuals

Year 2009, , 79 - 88, 01.06.2009

Zuhal Uçkun Aylin Üstündağ Mehmet Korkmaz Yalçın Duydu

https://doi.org/10.1501/Eczfak_0000000518

Abstract

Çalışmanın amacı bor maruziyetinin insanlar üzerindeki genotoksik etkilerini araştırmaktı. Bora maruz kalan bireylerde SCE frekansları (7,28 ± 1,60) kontrol grubuna (9,50 ± 1,83) göre önemli oranda düşüktü (Mann Whitney U- test, p<0,05). Benzer düşüş bora maruz kalan bireylerin MN değerlerinde de gözlenmiştir. Ancak maruz grup (9,81 ± 1,94) ile kontrol grubun (20,32 ± 3,98) MN değerleri arasındaki farklılık istatistiksel olarak anlamlı değildir (χ2 testi, p>0,05). Bu sonuçlar borun oluşabilecek genetik hasarlara karşı koruyucu bir etkisinin olabileceğini düşündürmektedir. Ancak daha fazla çalışmaların yapılması gerekmektedir

Keywords

Bor, Bor Genotoksitesi, Lenfosit, Mikroçekirdek, Kardeş kromatid değişimi

MICRONUCLEUS LEVELS AND SISTER CHROMATIDE EXCHANGE FREQUENCIES IN BORON EXPOSED AND CONTROL INDIVIDUALS

Year 2009, , 79 - 88, 01.06.2009

Zuhal Uçkun Aylin Üstündağ Mehmet Korkmaz Yalçın Duydu

https://doi.org/10.1501/Eczfak_0000000518

Abstract

The aim of the study was to investigate the genotoxic effects in boron exposed humans. SCE frequencies in boron exposed and control group were 7,28 ± 1,60 and 9,50 ± 1,83, respectively. SCE frequencies in boron exposed individuals were significantly lower than the controls (Mann Whitney U- test, p<0,05). The MN values in boron exposed individuals were also lower than the control group. Nevertheless the difference between boron exposed humans and controls was statistically not significant (χ2 test, p>0,05). In spite of the statistical insignificancy, lower MN values were also observed in boron exposed group. When these results were taken into consideration the decrease in SCE and MN values might be a reflection of a protective effect of boron aganist DNA damage. However this suggestion surely needs further investigation

Keywords

Boron, Genotoxicity of boron, Lymphocytes, Micronucleus, Sister chromatide exchange

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Details

Other ID	JA45DY43DN
Journal Section	Research Article
Authors	Zuhal Uçkun This is me Aylin Üstündağ This is me Mehmet Korkmaz This is me Yalçın Duydu This is me
Publication Date	June 1, 2009
Submission Date	June 1, 2009
Published in Issue	Year 2009

Cite

APA	Uçkun, Z., Üstündağ, A., Korkmaz, M., Duydu, Y. (2009). MICRONUCLEUS LEVELS AND SISTER CHROMATIDE EXCHANGE FREQUENCIES IN BORON EXPOSED AND CONTROL INDIVIDUALS. Journal of Faculty of Pharmacy of Ankara University, 38(2), 79-88. https://doi.org/10.1501/Eczfak_0000000518
AMA	Uçkun Z, Üstündağ A, Korkmaz M, Duydu Y. MICRONUCLEUS LEVELS AND SISTER CHROMATIDE EXCHANGE FREQUENCIES IN BORON EXPOSED AND CONTROL INDIVIDUALS. Ankara Ecz. Fak. Derg. June 2009;38(2):79-88. doi:10.1501/Eczfak_0000000518
Chicago	Uçkun, Zuhal, Aylin Üstündağ, Mehmet Korkmaz, and Yalçın Duydu. “MICRONUCLEUS LEVELS AND SISTER CHROMATIDE EXCHANGE FREQUENCIES IN BORON EXPOSED AND CONTROL INDIVIDUALS”. Journal of Faculty of Pharmacy of Ankara University 38, no. 2 (June 2009): 79-88. https://doi.org/10.1501/Eczfak_0000000518.
EndNote	Uçkun Z, Üstündağ A, Korkmaz M, Duydu Y (June 1, 2009) MICRONUCLEUS LEVELS AND SISTER CHROMATIDE EXCHANGE FREQUENCIES IN BORON EXPOSED AND CONTROL INDIVIDUALS. Journal of Faculty of Pharmacy of Ankara University 38 2 79–88.
IEEE	Z. Uçkun, A. Üstündağ, M. Korkmaz, and Y. Duydu, “MICRONUCLEUS LEVELS AND SISTER CHROMATIDE EXCHANGE FREQUENCIES IN BORON EXPOSED AND CONTROL INDIVIDUALS”, Ankara Ecz. Fak. Derg., vol. 38, no. 2, pp. 79–88, 2009, doi: 10.1501/Eczfak_0000000518.
ISNAD	Uçkun, Zuhal et al. “MICRONUCLEUS LEVELS AND SISTER CHROMATIDE EXCHANGE FREQUENCIES IN BORON EXPOSED AND CONTROL INDIVIDUALS”. Journal of Faculty of Pharmacy of Ankara University 38/2 (June 2009), 79-88. https://doi.org/10.1501/Eczfak_0000000518.
JAMA	Uçkun Z, Üstündağ A, Korkmaz M, Duydu Y. MICRONUCLEUS LEVELS AND SISTER CHROMATIDE EXCHANGE FREQUENCIES IN BORON EXPOSED AND CONTROL INDIVIDUALS. Ankara Ecz. Fak. Derg. 2009;38:79–88.
MLA	Uçkun, Zuhal et al. “MICRONUCLEUS LEVELS AND SISTER CHROMATIDE EXCHANGE FREQUENCIES IN BORON EXPOSED AND CONTROL INDIVIDUALS”. Journal of Faculty of Pharmacy of Ankara University, vol. 38, no. 2, 2009, pp. 79-88, doi:10.1501/Eczfak_0000000518.
Vancouver	Uçkun Z, Üstündağ A, Korkmaz M, Duydu Y. MICRONUCLEUS LEVELS AND SISTER CHROMATIDE EXCHANGE FREQUENCIES IN BORON EXPOSED AND CONTROL INDIVIDUALS. Ankara Ecz. Fak. Derg. 2009;38(2):79-88.

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Kapsam ve Amaç

Ankara Üniversitesi Eczacılık Fakültesi Dergisi, açık erişim, hakemli bir dergi olup Türkçe veya İngilizce olarak farmasötik bilimler alanındaki önemli gelişmeleri içeren orijinal araştırmalar, derlemeler ve kısa bildiriler için uluslararası bir yayım ortamıdır. Bilimsel toplantılarda sunulan bildiriler supleman özel sayısı olarak dergide yayımlanabilir. Ayrıca, tüm farmasötik alandaki gelecek ve önceki ulusal ve uluslararası bilimsel toplantılar ile sosyal aktiviteleri içerir.