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ETİL {5-[(2-(4-KLOROBENZİLSULFANİL)-4-KLOROTİYAZOL-5- İL)METİLEN]-2,4-DİOKSO-TİYAZOLİDİN–3-İL} ASETAT BİLEŞİĞİNİN SENTEZİ VE ALDOZ REDÜKTAZ İNHİBİTÖR ETKİSİ : SYNTHESIS AND ALDOSE REDUCTASE INHIBITORY

Year 2006, , 245 - 254, 01.12.2006

Oya Bozdağ Dündar

https://doi.org/10.1501/Eczfak_0000000067

Abstract

Bu çalışmada, etil {5-[(2-(4-klorobenzilsulfanil)-4-klorotiyazol-5-il)metilen]-2,4-dioksotiyazolidin–3-il}asetat bileşiği sentez edilmiş ve yapısı IR, 1H-NMR, mass and elementel analiz bulguları ile aydınlatılmıştır. Sentez edilen bileşiğin, in-vitro ortamda spektrofotometrik olarak sıçan böbrek AR’ını inhibe etme gücü test edilmiştir. Sentez edilen bileşik % 6.51±0.97 inhibitor aktivite göstermiştir

Keywords

Tiyazolidin-2 4-dionlar tiyazol türevleri aldoz redüktaz inhibitör etki

SYNTHESIS AND ALDOSE REDUCTASE INHIBITORY EFFECT OF ETHYL {5-[(2- (4-CHLORO-BENZYLSULPHANYL)- 4-CHLORO-THİAZOLE-5-YL)METHYLENE]- 2,4-DIOXO-THİAZOLİDİNE–3-YL}ACETATE

Year 2006, , 245 - 254, 01.12.2006

Oya Bozdağ Dündar

https://doi.org/10.1501/Eczfak_0000000067

Abstract

In this study, ethyl {5-[(2-(4-chlorobenzylsulphanyl)-4-chlorothiazole-5-yl)methylene]-2,4-dioxothiazolidine–3-yl}acetate compound was synthesized and its structure has been elucidated by IR, 1H-NMR, mass spectra and elementary analysis. The synthesized compound was tested for its ability to inhibit rat kidney AR by an in-vitro spectrophotometric assay. Synthesized compound showed inhibitory activity, 6.51±0.97 %

Keywords

Thiazolidine-2 4-diones thiazole derivatives aldose reductase inhibitory effect

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Details

Other ID JA75SC97AP
Journal Section Research Article
Authors

Oya Bozdağ Dündar This is me

Publication Date December 1, 2006
Submission Date December 1, 2006
Published in Issue Year 2006

Cite

APA Bozdağ Dündar, O. (2006). SYNTHESIS AND ALDOSE REDUCTASE INHIBITORY EFFECT OF ETHYL {5-[(2- (4-CHLORO-BENZYLSULPHANYL)- 4-CHLORO-THİAZOLE-5-YL)METHYLENE]- 2,4-DIOXO-THİAZOLİDİNE–3-YL}ACETATE. Journal of Faculty of Pharmacy of Ankara University, 35(4), 245-254. https://doi.org/10.1501/Eczfak_0000000067
AMA Bozdağ Dündar O. SYNTHESIS AND ALDOSE REDUCTASE INHIBITORY EFFECT OF ETHYL {5-[(2- (4-CHLORO-BENZYLSULPHANYL)- 4-CHLORO-THİAZOLE-5-YL)METHYLENE]- 2,4-DIOXO-THİAZOLİDİNE–3-YL}ACETATE. Ankara Ecz. Fak. Derg. December 2006;35(4):245-254. doi:10.1501/Eczfak_0000000067
Chicago Bozdağ Dündar, Oya. “SYNTHESIS AND ALDOSE REDUCTASE INHIBITORY EFFECT OF ETHYL {5-[(2- (4-CHLORO-BENZYLSULPHANYL)- 4-CHLORO-THİAZOLE-5-YL)METHYLENE]- 2,4-DIOXO-THİAZOLİDİNE–3-YL}ACETATE”. Journal of Faculty of Pharmacy of Ankara University 35, no. 4 (December 2006): 245-54. https://doi.org/10.1501/Eczfak_0000000067.
EndNote Bozdağ Dündar O (December 1, 2006) SYNTHESIS AND ALDOSE REDUCTASE INHIBITORY EFFECT OF ETHYL {5-[(2- (4-CHLORO-BENZYLSULPHANYL)- 4-CHLORO-THİAZOLE-5-YL)METHYLENE]- 2,4-DIOXO-THİAZOLİDİNE–3-YL}ACETATE. Journal of Faculty of Pharmacy of Ankara University 35 4 245–254.
IEEE O. Bozdağ Dündar, “SYNTHESIS AND ALDOSE REDUCTASE INHIBITORY EFFECT OF ETHYL {5-[(2- (4-CHLORO-BENZYLSULPHANYL)- 4-CHLORO-THİAZOLE-5-YL)METHYLENE]- 2,4-DIOXO-THİAZOLİDİNE–3-YL}ACETATE”, Ankara Ecz. Fak. Derg., vol. 35, no. 4, pp. 245–254, 2006, doi: 10.1501/Eczfak_0000000067.
ISNAD Bozdağ Dündar, Oya. “SYNTHESIS AND ALDOSE REDUCTASE INHIBITORY EFFECT OF ETHYL {5-[(2- (4-CHLORO-BENZYLSULPHANYL)- 4-CHLORO-THİAZOLE-5-YL)METHYLENE]- 2,4-DIOXO-THİAZOLİDİNE–3-YL}ACETATE”. Journal of Faculty of Pharmacy of Ankara University 35/4 (December 2006), 245-254. https://doi.org/10.1501/Eczfak_0000000067.
JAMA Bozdağ Dündar O. SYNTHESIS AND ALDOSE REDUCTASE INHIBITORY EFFECT OF ETHYL {5-[(2- (4-CHLORO-BENZYLSULPHANYL)- 4-CHLORO-THİAZOLE-5-YL)METHYLENE]- 2,4-DIOXO-THİAZOLİDİNE–3-YL}ACETATE. Ankara Ecz. Fak. Derg. 2006;35:245–254.
MLA Bozdağ Dündar, Oya. “SYNTHESIS AND ALDOSE REDUCTASE INHIBITORY EFFECT OF ETHYL {5-[(2- (4-CHLORO-BENZYLSULPHANYL)- 4-CHLORO-THİAZOLE-5-YL)METHYLENE]- 2,4-DIOXO-THİAZOLİDİNE–3-YL}ACETATE”. Journal of Faculty of Pharmacy of Ankara University, vol. 35, no. 4, 2006, pp. 245-54, doi:10.1501/Eczfak_0000000067.
Vancouver Bozdağ Dündar O. SYNTHESIS AND ALDOSE REDUCTASE INHIBITORY EFFECT OF ETHYL {5-[(2- (4-CHLORO-BENZYLSULPHANYL)- 4-CHLORO-THİAZOLE-5-YL)METHYLENE]- 2,4-DIOXO-THİAZOLİDİNE–3-YL}ACETATE. Ankara Ecz. Fak. Derg. 2006;35(4):245-54.

Kapsam ve Amaç

Ankara Üniversitesi Eczacılık Fakültesi Dergisi, açık erişim, hakemli bir dergi olup Türkçe veya İngilizce olarak farmasötik bilimler alanındaki önemli gelişmeleri içeren orijinal araştırmalar, derlemeler ve kısa bildiriler için uluslararası bir yayım ortamıdır. Bilimsel toplantılarda sunulan bildiriler supleman özel sayısı olarak dergide yayımlanabilir. Ayrıca, tüm farmasötik alandaki gelecek ve önceki ulusal ve uluslararası bilimsel toplantılar ile sosyal aktiviteleri içerir.