QSARs OF SOME NOVEL BENZOXAZOLE, BENZIMIDAZOLE ANDOXAZOLO(4,5-b)PYRIDINE DERIVATIVES AGAINST

İlkay Ören; Temiz Arpacı Özlem; İsmail Yalçın; Akı Şener Esin

doi:10.1501/Eczfak_0000000370

TR EN

QSARs OF SOME NOVEL BENZOXAZOLE, BENZIMIDAZOLE ANDOXAZOLO(4,5-b)PYRIDINE DERIVATIVES AGAINST

Abstract

For QSAR analysis of a set of previously synthesized 2,5,6-trisubstituted benzoxazole, benz.imidazole and 2-substituted oxazolo(4,5-b)pyridine derivatives tested for growth inhibitory activity against Candida albicans, was peiformed by using the computer-assisted multiple regression procedure. The activity contributions for either heterocyclic ring systems or substituent effects of these compounds were determined from the correlation equation for predictions of the lead optimization. The resulting QSAR revealed that the oxazolo(4,5-b)pyridine ring system substituted with a benzyl moiety at position 2 was the most favourable structure among the analysed fused ring systems. Moreover, the 5 ' position in the heterocyclic nucleus was found more significant than the other positions for improving the activity

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Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences

Journal Section

Research Article

Authors

İlkay Ören This is me

Temiz Arpacı Özlem This is me

İsmail Yalçın This is me

Akı Şener Esin This is me

Publication Date

March 1, 2002

Submission Date

March 1, 2002

Acceptance Date

-

Published in Issue

Year 2002 Volume: 31 Number: 1

DOI

https://doi.org/10.1501/Eczfak_0000000370

IZ

https://izlik.org/JA75PE65BZ

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RIS / Bibtex

APA

Ören, İ., Arpacı Özlem, T., Yalçın, İ., & Şener Esin, A. (2002). QSARs OF SOME NOVEL BENZOXAZOLE, BENZIMIDAZOLE ANDOXAZOLO(4,5-b)PYRIDINE DERIVATIVES AGAINST. Journal of Faculty of Pharmacy of Ankara University, 31(1), 21-32. https://doi.org/10.1501/Eczfak_0000000370

AMA

1.Ören İ, Arpacı Özlem T, Yalçın İ, Şener Esin A. QSARs OF SOME NOVEL BENZOXAZOLE, BENZIMIDAZOLE ANDOXAZOLO(4,5-b)PYRIDINE DERIVATIVES AGAINST. J. Fac. Pharm. Ankara. 2002;31(1):21-32. doi:10.1501/Eczfak_0000000370

Chicago

Ören, İlkay, Temiz Arpacı Özlem, İsmail Yalçın, and Akı Şener Esin. 2002. “QSARs OF SOME NOVEL BENZOXAZOLE, BENZIMIDAZOLE ANDOXAZOLO(4,5-B)PYRIDINE DERIVATIVES AGAINST”. Journal of Faculty of Pharmacy of Ankara University 31 (1): 21-32. https://doi.org/10.1501/Eczfak_0000000370.

EndNote

Ören İ, Arpacı Özlem T, Yalçın İ, Şener Esin A (March 1, 2002) QSARs OF SOME NOVEL BENZOXAZOLE, BENZIMIDAZOLE ANDOXAZOLO(4,5-b)PYRIDINE DERIVATIVES AGAINST. Journal of Faculty of Pharmacy of Ankara University 31 1 21–32.

IEEE

[1]İ. Ören, T. Arpacı Özlem, İ. Yalçın, and A. Şener Esin, “QSARs OF SOME NOVEL BENZOXAZOLE, BENZIMIDAZOLE ANDOXAZOLO(4,5-b)PYRIDINE DERIVATIVES AGAINST”, J. Fac. Pharm. Ankara, vol. 31, no. 1, pp. 21–32, Mar. 2002, doi: 10.1501/Eczfak_0000000370.

ISNAD

Ören, İlkay - Arpacı Özlem, Temiz - Yalçın, İsmail - Şener Esin, Akı. “QSARs OF SOME NOVEL BENZOXAZOLE, BENZIMIDAZOLE ANDOXAZOLO(4,5-B)PYRIDINE DERIVATIVES AGAINST”. Journal of Faculty of Pharmacy of Ankara University 31/1 (March 1, 2002): 21-32. https://doi.org/10.1501/Eczfak_0000000370.

JAMA

1.Ören İ, Arpacı Özlem T, Yalçın İ, Şener Esin A. QSARs OF SOME NOVEL BENZOXAZOLE, BENZIMIDAZOLE ANDOXAZOLO(4,5-b)PYRIDINE DERIVATIVES AGAINST. J. Fac. Pharm. Ankara. 2002;31:21–32.

MLA

Ören, İlkay, et al. “QSARs OF SOME NOVEL BENZOXAZOLE, BENZIMIDAZOLE ANDOXAZOLO(4,5-B)PYRIDINE DERIVATIVES AGAINST”. Journal of Faculty of Pharmacy of Ankara University, vol. 31, no. 1, Mar. 2002, pp. 21-32, doi:10.1501/Eczfak_0000000370.

Vancouver

1.İlkay Ören, Temiz Arpacı Özlem, İsmail Yalçın, Akı Şener Esin. QSARs OF SOME NOVEL BENZOXAZOLE, BENZIMIDAZOLE ANDOXAZOLO(4,5-b)PYRIDINE DERIVATIVES AGAINST. J. Fac. Pharm. Ankara. 2002 Mar. 1;31(1):21-32. doi:10.1501/Eczfak_0000000370

QSARs OF SOME NOVEL BENZOXAZOLE, BENZIMIDAZOLE ANDOXAZOLO(4,5-b)PYRIDINE DERIVATIVES AGAINST

BAZI BENZOKSAZOL, BENZİMİDAZOL VE OKSAZOLO(4,5-b)PİRİDİNTÜREVLERİNİN C. albicans'a KARŞI KANTİTATİF YAPI-ETKİ İLİŞKİLERİ

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QSARs OF SOME NOVEL BENZOXAZOLE, BENZIMIDAZOLE ANDOXAZOLO(4,5-b)PYRIDINE DERIVATIVES AGAINST

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