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İN VİTRO ŞARTLARDA N- NİTROZOPROLİDİN'İN TAVŞAN KARACİĞER VE BÖBREK GLUTATYON -S- TRANSFERAZ AKTİVİTESİNE ETKİSİNİN ARAŞTIRILMASI

Year 2001, , 0 - 0, 01.09.2001

İzzet Yelkovan İsmihan Göze Sevtap Bakır

https://doi.org/10.1501/Eczfak_0000000361

Abstract

Çalışmada tavşan karaciğerinden ve böbreklerinden izole edilen Glutatyon-S- Transferaz'ın kanserojen etkili bir madde olan N-nitrozoprolidin ile etkileşimi incelendi. Glutatyon -S-Transferaz enzimi in vitro şartlarda değişik dozlarda N-nitrozoprolidin ile muamele edilerek, reaksiyonları gözlendi. Bulgular 1 kloro 2 ,4 dinitro benzen (KDNB) substrat olarak kullanıldığında bulunan aktivite ile karşılaştırıldı. Regresyon ve korelasyon analizi yapıldı. Sonuçlar spesifik aktivite olarak verildi

Keywords

N-nitrozoprolidin Glutatyon -S-transferaz

AN INVESTIGATION ON THE EFFECT OF N-NITROSOPYROLLIDINE ON THE RABBIT LIVER AND KIDNEY GLUTATHIONE-S-TRANSFERASE ACTIVITY

Year 2001, , 0 - 0, 01.09.2001

İzzet Yelkovan İsmihan Göze Sevtap Bakır

https://doi.org/10.1501/Eczfak_0000000361

Abstract

We analyzed the interaction of glutation- S- transferase, which is isolated from the liver and kidney of rabbits with N-nitrosopyrollidine which is an effective carsinojenic. Glutathione-S-transferase enzymes were treated with N-nitrosopyrollidine in vitro conditions at various doses, and the reactions were recorded. The activities observed were compared with that of the activity observed in the presence of 1 chloro 2, 4 dinitrobenzen as a substrate and a regression analysis was performed to investigate the correlation. The result were expressed as spesific activities

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Details

Other ID JA82ZJ88ZM
Journal Section Research Article
Authors

İzzet Yelkovan This is me

İsmihan Göze This is me

Sevtap Bakır This is me

Publication Date September 1, 2001
Submission Date September 1, 2001
Published in Issue Year 2001

Cite

APA Yelkovan, İ., Göze, İ., & Bakır, S. (2001). AN INVESTIGATION ON THE EFFECT OF N-NITROSOPYROLLIDINE ON THE RABBIT LIVER AND KIDNEY GLUTATHIONE-S-TRANSFERASE ACTIVITY. Journal of Faculty of Pharmacy of Ankara University, 30(3). https://doi.org/10.1501/Eczfak_0000000361
AMA Yelkovan İ, Göze İ, Bakır S. AN INVESTIGATION ON THE EFFECT OF N-NITROSOPYROLLIDINE ON THE RABBIT LIVER AND KIDNEY GLUTATHIONE-S-TRANSFERASE ACTIVITY. Ankara Ecz. Fak. Derg. September 2001;30(3). doi:10.1501/Eczfak_0000000361
Chicago Yelkovan, İzzet, İsmihan Göze, and Sevtap Bakır. “AN INVESTIGATION ON THE EFFECT OF N-NITROSOPYROLLIDINE ON THE RABBIT LIVER AND KIDNEY GLUTATHIONE-S-TRANSFERASE ACTIVITY”. Journal of Faculty of Pharmacy of Ankara University 30, no. 3 (September 2001). https://doi.org/10.1501/Eczfak_0000000361.
EndNote Yelkovan İ, Göze İ, Bakır S (September 1, 2001) AN INVESTIGATION ON THE EFFECT OF N-NITROSOPYROLLIDINE ON THE RABBIT LIVER AND KIDNEY GLUTATHIONE-S-TRANSFERASE ACTIVITY. Journal of Faculty of Pharmacy of Ankara University 30 3
IEEE İ. Yelkovan, İ. Göze, and S. Bakır, “AN INVESTIGATION ON THE EFFECT OF N-NITROSOPYROLLIDINE ON THE RABBIT LIVER AND KIDNEY GLUTATHIONE-S-TRANSFERASE ACTIVITY”, Ankara Ecz. Fak. Derg., vol. 30, no. 3, 2001, doi: 10.1501/Eczfak_0000000361.
ISNAD Yelkovan, İzzet et al. “AN INVESTIGATION ON THE EFFECT OF N-NITROSOPYROLLIDINE ON THE RABBIT LIVER AND KIDNEY GLUTATHIONE-S-TRANSFERASE ACTIVITY”. Journal of Faculty of Pharmacy of Ankara University 30/3 (September 2001). https://doi.org/10.1501/Eczfak_0000000361.
JAMA Yelkovan İ, Göze İ, Bakır S. AN INVESTIGATION ON THE EFFECT OF N-NITROSOPYROLLIDINE ON THE RABBIT LIVER AND KIDNEY GLUTATHIONE-S-TRANSFERASE ACTIVITY. Ankara Ecz. Fak. Derg. 2001;30. doi:10.1501/Eczfak_0000000361.
MLA Yelkovan, İzzet et al. “AN INVESTIGATION ON THE EFFECT OF N-NITROSOPYROLLIDINE ON THE RABBIT LIVER AND KIDNEY GLUTATHIONE-S-TRANSFERASE ACTIVITY”. Journal of Faculty of Pharmacy of Ankara University, vol. 30, no. 3, 2001, doi:10.1501/Eczfak_0000000361.
Vancouver Yelkovan İ, Göze İ, Bakır S. AN INVESTIGATION ON THE EFFECT OF N-NITROSOPYROLLIDINE ON THE RABBIT LIVER AND KIDNEY GLUTATHIONE-S-TRANSFERASE ACTIVITY. Ankara Ecz. Fak. Derg. 2001;30(3).

Kapsam ve Amaç

Ankara Üniversitesi Eczacılık Fakültesi Dergisi, açık erişim, hakemli bir dergi olup Türkçe veya İngilizce olarak farmasötik bilimler alanındaki önemli gelişmeleri içeren orijinal araştırmalar, derlemeler ve kısa bildiriler için uluslararası bir yayım ortamıdır. Bilimsel toplantılarda sunulan bildiriler supleman özel sayısı olarak dergide yayımlanabilir. Ayrıca, tüm farmasötik alandaki gelecek ve önceki ulusal ve uluslararası bilimsel toplantılar ile sosyal aktiviteleri içerir.