Levodopa ve Benserazid'in Türev Spektrofotometrisi ile Birarada Tayini

Year 1994, , 0 - 0, 01.06.1994

Cem Yücesoy

https://doi.org/10.1501/Eczfak_0000000146

Abstract

Bu çalışmada, levodopa ve benserazidin kombine preparatlarından birarada tayini için spektrofotometrik yöntemler geliştirilmiştir. Yöntemler, levodopanın 0.1 N HCI'deki çözeltisinin birinci türev spektrumunda 271.6 nm de (I), ikinci türev spektrumunda 239.4 nm de (II) ve benserazidin 0.1 N HC1 deki çözeltisinin ikinci türev spektrumunda 219.4 nm de ölçümüne dayanmaktadır. Sözkonusu bileşiklerin standart ilavesi yöntemiyle % geriye kazanımları levodopa için % 100.6 (I) ve % 99.2 (11), benserazid için ise % 100.2 dir. Bu

Keywords

İlaç analizi, levodopa, benserazid, birarada tayin, türev spektrofotometrisi

Simultaneous Determination of Levodopa and Benserazide Using Derivative Spectrophotometry

Abstract

Direct spectrophotometric methods for the simultaneous determination of levodopa and benserazide in combined formulations are presented. The methods are based on the use of UV derivative spectrophotometric measurements -the first derivative at 271.6 nm (I) and the second derivative at 239.4 nm (II) for levodopa (in 0.1 N hydrochloric acid) and the second derivative at 219.4 nm for benserazide (in 0.1 N hydrochloric acid). The mean percentage recoveries of the drugs by standard addition method were 100.6 % (I) and 99.2 % (II) for levodopa and 100.2 % for benserazide, respectively. In replicate analyses of a sample of Madopar capsules, satisfactory precision was demonstrated by the relative standard deviations of 1.41 % (I) and 1 . 1 6 % (II) for levodopa and 1.49 % for benserazide

Keywords

Drug analysis, levodopa, benserazide, simultaneous determination, derivative spectrophotometry