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The Quantitative Structure-Activity Relationships of AntifungalActive 2- (p-Substituted-Phenyl) Benzoxazole DerivativesAgainst Candida Albicans Using The Combinations of SomeHydrophobic, Electronic And Steric Parameters

Year 1986, , 24 - 30, 01.06.1986

Esin Şener İsmail Yalçın Seçkin Özden Tuncel Özden

https://doi.org/10.1501/Eczfak_0000000483

Abstract

The antifungal active 2-(p-substitutcd-phenyl) benzoxazoles
against C. albicans were studied in a QSAR (quantitative structureactivity
relationships) work using the multiple regression method.
Some of the hydrophobic , electronic ( F, R) and steric (MR,
MW, Pr
) constants were used as physicochemical parameters. The
correlation equations and the best equation obtained from regression
analysis were given.
As a result of quantitative structure-activity relationships of
2-(p-substituted-phenyl) benzoxazoles for C. albicans, it was found
that hydrophobic, electronic or steric parameters were more significant
when they were used in combined forms than they were used separately.

Keywords

2-(p-Substituted-phenyl) benzoxazoles F R MR MW Pr QSAR Best equation C. albicans.

Candida Albicans'a Karşı Antifungal Etkili 2-(p-Sübstitüe-Fenil) Benzoksazol Türevleri ile Bazı Hidrofobik, Elektronik, Sterik Parametreler Kombinasyonlarının Kantitatif Yapı-Etki ilişkileri

Year 1986, , 24 - 30, 01.06.1986

Esin Şener İsmail Yalçın Seçkin Özden Tuncel Özden

https://doi.org/10.1501/Eczfak_0000000483

Abstract

Candida albicans'a karşı antifungal etkili 2-(p-sübstitüe-fenil)-
benzoxazol türevlerinin, çoklu regresyon metodu kullanılarak, kantitatif
yapı-etki ilişkileri (QSAR) çalışılmıştır. Fizikokimyasal para metreler olarak bazı hidrofobik , elektronik ( F, R) ve sterik
(MR, MW, Pr
) sabiteler kullanılmıştır. Regresyon analizleri sonucu
ele geçen korelasyon denklemleri ve ideal denklem çalışmada verilmiş-
tir.
2-(p-Sübstitüe-fenil) benzoksazol türevlerinin kantitatif yapı-etki
ilişkileri incelendiğinde, C. albicans için hidrofobik, elektronik ve
sterik parametrelerin tek tek kullanılmaları yerine, kombinasyonlarının
oldukça dikkate değer sonuçlar verdiği saptanmıştır.

Keywords

Candida Albicans Antifungal

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Details

Primary Language English
Subjects Pharmacology and Pharmaceutical Sciences
Other ID JA63PP47JJ
Journal Section Research Article
Authors

Esin Şener This is me

İsmail Yalçın This is me

Seçkin Özden This is me

Tuncel Özden This is me

Publication Date June 1, 1986
Submission Date June 1, 1986
Published in Issue Year 1986

Cite

APA Şener, E., Yalçın, İ., Özden, S., Özden, T. (1986). The Quantitative Structure-Activity Relationships of AntifungalActive 2- (p-Substituted-Phenyl) Benzoxazole DerivativesAgainst Candida Albicans Using The Combinations of SomeHydrophobic, Electronic And Steric Parameters. Journal of Faculty of Pharmacy of Ankara University, 16(1), 24-30. https://doi.org/10.1501/Eczfak_0000000483
AMA Şener E, Yalçın İ, Özden S, Özden T. The Quantitative Structure-Activity Relationships of AntifungalActive 2- (p-Substituted-Phenyl) Benzoxazole DerivativesAgainst Candida Albicans Using The Combinations of SomeHydrophobic, Electronic And Steric Parameters. Ankara Ecz. Fak. Derg. June 1986;16(1):24-30. doi:10.1501/Eczfak_0000000483
Chicago Şener, Esin, İsmail Yalçın, Seçkin Özden, and Tuncel Özden. “The Quantitative Structure-Activity Relationships of AntifungalActive 2- (p-Substituted-Phenyl) Benzoxazole DerivativesAgainst Candida Albicans Using The Combinations of SomeHydrophobic, Electronic And Steric Parameters”. Journal of Faculty of Pharmacy of Ankara University 16, no. 1 (June 1986): 24-30. https://doi.org/10.1501/Eczfak_0000000483.
EndNote Şener E, Yalçın İ, Özden S, Özden T (June 1, 1986) The Quantitative Structure-Activity Relationships of AntifungalActive 2- (p-Substituted-Phenyl) Benzoxazole DerivativesAgainst Candida Albicans Using The Combinations of SomeHydrophobic, Electronic And Steric Parameters. Journal of Faculty of Pharmacy of Ankara University 16 1 24–30.
IEEE E. Şener, İ. Yalçın, S. Özden, and T. Özden, “The Quantitative Structure-Activity Relationships of AntifungalActive 2- (p-Substituted-Phenyl) Benzoxazole DerivativesAgainst Candida Albicans Using The Combinations of SomeHydrophobic, Electronic And Steric Parameters”, Ankara Ecz. Fak. Derg., vol. 16, no. 1, pp. 24–30, 1986, doi: 10.1501/Eczfak_0000000483.
ISNAD Şener, Esin et al. “The Quantitative Structure-Activity Relationships of AntifungalActive 2- (p-Substituted-Phenyl) Benzoxazole DerivativesAgainst Candida Albicans Using The Combinations of SomeHydrophobic, Electronic And Steric Parameters”. Journal of Faculty of Pharmacy of Ankara University 16/1 (June 1986), 24-30. https://doi.org/10.1501/Eczfak_0000000483.
JAMA Şener E, Yalçın İ, Özden S, Özden T. The Quantitative Structure-Activity Relationships of AntifungalActive 2- (p-Substituted-Phenyl) Benzoxazole DerivativesAgainst Candida Albicans Using The Combinations of SomeHydrophobic, Electronic And Steric Parameters. Ankara Ecz. Fak. Derg. 1986;16:24–30.
MLA Şener, Esin et al. “The Quantitative Structure-Activity Relationships of AntifungalActive 2- (p-Substituted-Phenyl) Benzoxazole DerivativesAgainst Candida Albicans Using The Combinations of SomeHydrophobic, Electronic And Steric Parameters”. Journal of Faculty of Pharmacy of Ankara University, vol. 16, no. 1, 1986, pp. 24-30, doi:10.1501/Eczfak_0000000483.
Vancouver Şener E, Yalçın İ, Özden S, Özden T. The Quantitative Structure-Activity Relationships of AntifungalActive 2- (p-Substituted-Phenyl) Benzoxazole DerivativesAgainst Candida Albicans Using The Combinations of SomeHydrophobic, Electronic And Steric Parameters. Ankara Ecz. Fak. Derg. 1986;16(1):24-30.

Kapsam ve Amaç

Ankara Üniversitesi Eczacılık Fakültesi Dergisi, açık erişim, hakemli bir dergi olup Türkçe veya İngilizce olarak farmasötik bilimler alanındaki önemli gelişmeleri içeren orijinal araştırmalar, derlemeler ve kısa bildiriler için uluslararası bir yayım ortamıdır. Bilimsel toplantılarda sunulan bildiriler supleman özel sayısı olarak dergide yayımlanabilir. Ayrıca, tüm farmasötik alandaki gelecek ve önceki ulusal ve uluslararası bilimsel toplantılar ile sosyal aktiviteleri içerir.