TAVŞANLARDA GEBELİK SONLANDIRMADA AGLEPRİSTON KULLANIMI

Abstract

Amaç: Tavşanlarda gebeliğin sonlandırılmasında aglepriston kullanımın araştırılması. Aglepriston (RU 46534) progesteron (P4) antagonisti olan sentetik yapılı steroid hormondur. Birçok hayvan türünde olduğu gibi tavşanlarda da istenmeyen gebeliklerin sonlandırılmasında kullanılmaktadır. Tavşanlarda gebeliğin devamlılığından sorumlu primer hormon P4 dür. Aglepriston tavşanlarda progesteron reseptörlerine (PR) P4’den 3,8 kat daha hızlı bağlanmaktadır. Bu nedenle gebelik sonlandırmada %100 başarı sağlamaktadır. Etkin dozu 10mg/kg 24 saat arayla iki kez ve uygulama yolu subcutan olarak belirtilmiştir. Tavşanlarda gebeliğin 5-6 gününden 15. gününe kadar kullanılması uygundur.  Aglepriston erken dönem gebeliğin sonlandırılmasında kullanıldığında embriyo rezorbe olarak vajinal kanama ve akıntı oluşmadığı bildirilmiştir. Ancak orta dönem gebelikleri sonlandırma uygulamalarında fetüsün atılıp kanlı vajinal akıntının oluştuğu görülmüştür. Ayrıca sonraki dönemlerde fertilite parametrelerinde anlamlı bir farklılık görülmezken her iki dönem uygulamalarında da düzensiz çiftleşme eğilimi ile beraber doğum gebe kalma aralığının uzadığı olgular tespit edilmiştir. Bunun yanında sitotoksik, genotoksik etkileri ve bazı hemotolojik parametrelerde değişimlere neden olduğu anlaşıldı.

      Sonuç ve Tartışma: Aglepristonun tedavi başarısızlığı henüz bildirilmemiş olmasına rağmen gebelik sonlandırmadaki etkisinin yanında maternal değişimler üzerine hematolojik düzeyde etkisinin araştırılmasının önemli olacağı düşünüldü.

Keywords

• aglepriston,gebelik,progesteron,tavşan

AGLEPRISTONE USE FOR TERMINATION OF PREGNANCY IN RABBITS

Abstract

Objective: It is the investigation of aglepriston use in termination of pregnancy in the rabbits. Aglepriston (RU 46534) is a synthetic steroid hormone that is progesterone (P4) antagonist. It is used to terminate unwanted pregnancies in many animal species including rabbits. The P4 is primary hormone that is responsible for maintain of pregnancy in rabbits. Its affinity to PR is 3.8 times higher than P4 and so eliminates effect of P4. Therefore, aglepristone is provide 100% success in termination of pregnancy. The effective dose is 10 mg/kg subcutan twice 24 hours apart. It is suitable period for treatment between 5-6th and 15th days of pregnancy in rabbits. It was reported that when aglepristone was used to terminate early pregnancy, vaginal bleeding and discharge didn’t occur and it resulted in embryo resorption. But, in midpregnancy applications, it was recorded that resulted in fetal expulsion and vaginal bleeding and discharge were occured. In addition, it was stated that there was no significant difference in subsequent fertility parameters. But, in both applications, it was determined that irregular mating behavior and parturition to pregnancy interval extend. Besides, it was understood that aglepristone caused cytotoxic, genotoxic effects and changes in some hematological parameters in rabbits.

Result and Discussion: Although the treatment failure of agleprolone has not been reported yet, It was thought that it would be important to investigate toxic effects at the cellular level on maternal changes in addition to the effect of pregnancy termination.     

Sonuç ve Tartışma: Aglepristonun tedavi başarısızlığı henüz bildirilmemiş olmasına rağmen gebelik sonlandırmadaki etkisinin yanında maternal değişimler üzerine hematolojik düzeyde etkisinin araştırılmasının önemli olacağı düşünüldü.

Keywords

• aglepriston,pregnancy,progesterone,rabbit

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