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PROTECTIVE ROLE OF CRATAEGUS MONOGYNA ON SPERM QUALITY AND TESTIS OXIDATIVE STRESS AGAINST COPPER-INDUCED TOXICITY

Year 2020, , 452 - 469, 30.09.2020
https://doi.org/10.33483/jfpau.716103

Abstract

Objective: The purpose of this study was to investigate the possible beneficial use of common hawthorn Crataegus monogyna aqueous extract at 1.5g/Kg bw/day against chronic copper sulfate intoxication (100mg/Kg bw) in Wistar rats.
Material and Method: Animals were divided into 6 groups; the untreated control (C), 2 positive controls treated respectively with hawthorn fruits (F) and leaves (L), 1 group treated with copper (Cu) and 2 combined treatment groups treated with Cu and hawthorn-fruits (CuF) and Cu and hawthorn-leaves (CuL). After 30 days of oral administration, testis weight and plasma testosterone levels were evaluated, in addition to the epididymal sperm concentration, motility, vitality, velocity (VCL, VSL and VAP), the amplitude of lateral head displacement (ALH), and the beat cross frequency (BCF). Testicular glutathione (GSH), malondialdehyde (MDA), and glutathione peroxidase (GPx) were also evaluated.
Result and Discussion: Cu exposure reduced testosterone, sperm concentration, live sperm, VCL, VSL, VAP, ALH, BCF, GSH, and GPx levels compared to control groups. Dead sperm and MDA levels were increased in rats of Cu group compared to the untreated control. When compared to the Cu group, levels of testosterone, sperm concentration, sperm motility, live sperm, VCL, VSL, VAP, ALH, BCF, GSH, and GPx were much higher in the CuF and CuL groups, along with a significantly lower MDA concentration. In conclusion, hawthorn, when co-administered as an aqueous extract with Cu, protected most biological markers against copper toxicit, while positive control (s) boosted sperm concentration and velocity (VCL and VAP).

Supporting Institution

The General Directorate of Scientific Research and Technological Development (DGRSDT)

Project Number

number 06/2016, recipient C. ABDENNOUR

Thanks

Authors would like to thank The General Directorate of Scientific Research and Technological Development (DGRSDT) for financial support (Award number 06/2016, recipient C. ABDENNOUR). Thanks are also given to Pasteur Institute (Algiers) for providing rats.

References

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CRATAEGUS MONOGYNA’NIN, BAKIR KAYNAKLI TOKSİSİTEYE KARŞI SPERM KALİTESİ VE TESTİS OKSİDATİF STRESİ ÜZERİNDEKİ KORUYUCU ROLÜ

Year 2020, , 452 - 469, 30.09.2020
https://doi.org/10.33483/jfpau.716103

Abstract

Amaç: Bu çalışmanın amacı, Wistar sıçanlarında, kronik bakır sülfat zehirlenmesine (100mg / Kg bw) karşı yaygın alıç Crataegus monogyna sulu ekstraktının (1.5g / Kg bw/ gün) olası faydalı kullanımını araştırmaktır.
Gereç ve Yöntem: Hayvanlar, tedavi edilmemiş kontrol (C), sırasıyla alıç meyveleri (F) ve yaprakları (L) ile muamele edilmiş 2 pozitif kontrol, bakır (Cu) ile muamele edilmiş grup ve Cu ve alıç meyveleri (CuF) ve Cu ve alıç yaprakları (CuL) ile muamele edilmiş 2 kombine tedavi grubu olmak üzere 6 gruba ayrılmıştır. 30 günlük oral uygulamadan sonra, epididimal sperm konsantrasyonu, motilite, canlılık, hız (VCL, VSL ve VAP), dış yana baş deplasmanının amplitüdü (ALH) ve sperm kuyruğu vuruş sıklığının (BCF) yanısıra testis ağırlığı ve plazma testosteron seviyeleri değerlendirilmiştir. Ayrıca, testis glutatyonu (GSH), malondialdehid (MDA) ve glutatyonperoksidaz (GPx) da değerlendirilmiştir.
Sonuç ve Tartışma: Cu maruziyeti, kontrol gruplarına kıyasla testosteron, sperm konsantrasyonu, canlı sperm, VCL, VSL, VAP, ALH, BCF, GSH ve GPx seviyelerini azaltmıştır. Cu grubunun sıçanlarında ölü sperm ve MDA seviyeleri, tedavi edilmeyen kontrole kıyasla artmıştır. Cu grubuyla karşılaştırıldığında, testosteron seviyeleri, sperm konsantrasyonu, sperm motilitesi, canlı sperm, VCL, VSL, VAP, ALH, BCF, GSH ve GPx seviyeleri CuF ve CuL gruplarında çok daha yüksek ve MDA konsantrasyonları ise anlamlı olarak düşüktür. Sonuç olarak, alıç, Cu ile sulu bir özüt olarak uygulandığında, bakır toksisitesine karşı çoğu biyolojik belirteci korumuş ve sperm konsantrasyonunu ve hızını (VCL ve VAP) artırmıştır

Project Number

number 06/2016, recipient C. ABDENNOUR

References

  • 1. Badiye, A., Kapoor, N., Khajuria, H. (2013). Copper Toxicity: A Comprehensive Study. Research Journal of Recent Sciences, 2, 58-67.
  • 2. Sinkovic, A., Strdin, A., Svensek F. (2008). Severe acute copper sulphate poisoning: a case report. ArhHig Rada Toksikol, 59(1), 31-5.
  • 3. Blundell, S., Curtin, J., Fitzgerald, D. (2003). Blue lips, coma and haemolysis. Journal of Paediatrics and Child Health, 39(1), 67-8.
  • 4. Mario, M. (2014). Abnormal Copper Homeostasis: Mechanisms and Roles in Neurodegeneration, Toxics, 2, 327-345.
  • 5. Hagai, L., Niel, J., Anderson, M.A., Jaime, M., Dan, W.D., Irina, M., Rachel, P., Swan, H. (2017). Temporal trends in sperm counts: a systematic review and meta-regression analysis. Human reproduction updates, 23(6), 646-659. 6. Bamidele, R., Pelumi, O. (2017). Childlessness and Its Socio-Cultural Implication on Married Couples within Some Selected Yoruba Communities in South-West Nigeria. International Journal of Innovative Social Sciences & Humanities Research, 5(1), 42-54.
  • 7. Chen, L., Shi, G.R., Huang, D.D., Li, Y., Ma, C.C., Shia, M., Su, B.X., Shi, G.J. (2019). Male sexual dysfunction: A review of literature on its pathological mechanisms, potential risk factors, and herbal drug intervention. Biomedicine and Pharmacotherapy, 112, 108-585.
  • 8. Duruibe, J., Ogwuegbu, M.O.C., Egwurugwu, J. (2007). Heavy Metal Pollution and Human Biotoxic Effects. International journal of physical sciences, 2(5), 112–118.
  • 9. Swan, H.S., Elkin, E.P., Fenster, L. (2000). The question of declining sperm density revisited: an analysis of 101 studies published 1934–1996. Environmental Health Perspectives, 108(10), 961–966.
  • 10. Liu, J.Y., Yang, X.F., Sun, X., Zhuang, C., Xu, F., Li, Y. (2016). Suppressive Effects of Copper Sulfate Accumulation on the Spermatogenesis of Rats. Biological Trace Element Research, 174, 356–361.
  • 11. Wong, W.Y., Flik, G., Groenen, P.M.W., Swinkels, D.W., Thomas, C.M.G., Copius-Peereboom, J.H.J., Merkus, H.M.W.M., Steegers-Theunissen, R.P.M. ( 2001). The impact of calcium, magnesium, zinc, and copper in blood and seminal plasma on semen parameters in men. Reproductive Toxicology, 15, 131–136.
  • 12. Moriwaki, H., Osborne, M.R., Phillips, D.H.. (2008). Effect of mixing metal ions on oxidative DNA damage mediated by a Fentom-type reduction. Toxicology in Vitro, 22(1), 36-44.
  • 13. Eidi, M., Eidi, A., Pouyan, O., Shahmohammadi, P., Fazaeli, R., Bahar, M. (2011). Seminal plasma levels of copper and its relationship with seminal parameters. Iranian Journal of Reproductive Medicine, 8(2), 60-65.
  • 14. JibrinBala, Y., Meriçli, A.H. (2016). Pharmacological activities of Crataegus species: A review. International Journal of Multidisciplinary Research and Development, 3, 73-76.
  • 15. Fong, H.H., Bauman, J.L. (2002). Hawthorn. Journal of Cardiovascular Nursing, 16, 1–8.
  • 16. Rice-Evans, C. (2004). Flavonoids and isoflavones: absorption, metabolism, and bioactivity. Free Radical Biology and Medicine, 36(7), 827-8.
  • 17. Jeyendran, R.S., Vander-Van, H.H., Perez-Peleaz, M., Crabo, B.G., Zanevld, L.J.D. (1984). Development of an assay to assess the functional integrity of the human sperm membrane and its relationship to other semen characters. Journal of reproducion and fertility, 70(1), 219-228.
  • 18. Weckbercker, G., Cory, J.G. (1988). Ribonucleotide reductase activity and growth of glutathione depended mouse leukaemia L 1210 cells in vitro. Cancer Letters, 40, 257-264. 19. Bradford, M.M. (1976). Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding. Analytical Biochemistry, 72, 248-254.
  • 20. Ohkawa, H., Ohishi, N., Yagi, K. (1979). Assay for lipid peroxidation in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry, 95, 351-358.
  • 21. Flohe, L., Gunzler, W.A. (1984). Analysis of glutathione peroxidase. Methods of Enzymology, 105, 114-121.
  • 22. Chattopadhyay, A., Sarkar, M., Biswas, N.M. (2005). Dose-dependent effect of copper chloride on male reproductive function in immature rats. Kathmandu University Medical Journal, 3(4), 392-400.
  • 23. Mandil, R., Rahal, A., Parkash, A., Gangwar, S.K. (2016). Ameliorative potential of αtocophenol against flubendiamide and copper-induced testicular-insult in wistar rats. Chemico-bioloical interactions, 260, 91-101.
  • 24. Chang, CS., Choi, J.B., Kim, H.J., Park, S.B. (2011). Correlation between serum testosterone level and concentration of copper and zink in hair tissue. Bioloical Trace Element Research, 144(1-3), 264-271.
  • 25. Bedwal, R.S., Bahuguna, A. (1994). Zinc, copper and selenium in reproduction. Experientia, 50(7), 626–40.
  • 26. Wiebe, J.P., Salhanick, A.I., Myer, K.I. (1983). On the mechanism of action of lead in the testis: in vitro suppression of FSH receptors, cyclic AMP and steroidogenesis. Life Science, 32(17), 1997-2005.
  • 27. Krumschnabel, G., Manzal, C., Berger, C., Hofer, B. (2005). Oxidative stress, mitochondiral permeability transition, and cell death in Cu-exposed trout hepatocytes. ToxicalToxicology and Applied Pharmacology, 209(1), 62-73.
  • 28. Knazicka, Z., Tvrda, E., Bardos, L., Lukac, N. (2012). Dose- and time- dependent effect of copper ions on the viability of bull spermatozoa in different media. Journal of Environmental Science and Health Part A Toxic/Hazardous Substances and Environmental Engineering, 47(9), 1294-300. 9. Zhou, J., Chen, L., Li, J., Li, H., Hong, Z., Xie, M., Chen, S., Yao, B. (2015). The Semen pH Affects Sperm Motility and Capacitation. PLoS ONE, 10(7), e0132974.
  • 30. Jimenez, T., Sanchez, G., Wertheimer, E.V., Blanco, G. (2010). Activity of the Na,K-ATPase alpha4 isoform is impor- tant for membrane potential, intracellular Ca2+, and pH to maintain motility in rat spermatozoa. Reproduction, 139(5), 835–45. 31. Olivari, F.A., Hernẚndez, P.P., Allende, M.L. (2008). Acute copper exposure induces oxidative stress and cell death in lateral line hair cells of zebrafish larvea. Brain research, 1244, 1-12.
  • 32. Sadek, A.S., Abd El Shakour, A., Zaki A., Ibrahim, A.M., Mahmoud, I.S., Mostafa, T.B., (2011). Sperm chromatin condensation in infertile men with varicocele before and after surgical repair. Fertility and sterility, 95(5), 1705-8.
  • 33. Dupont, C.L., Grass, G., Rensing, C. (2011). Copper toxicity and the origin of bacterial resistance-new insights and applications. Metallomics, 3(11), 1109–1118.
  • 34. Witting, P.K., Bowry, V.W., Stocker, R. (1995). Inverse deuterium kinetic isotope effect for peroxidation in human low-density lipoprotein (LDL): a simple test for tocopherol- mediated peroxidation of LDL lipids. FEBS Letters, 375(1-2), 45-49.
  • 35. Sevcikova, M., Modra, H., Slaninova, A., Svobodova, Z. (2011). Metals as a cause of oxidative stress in fish: a review. Veterinárnímedicína, 56(11), 537-546.
  • 36. Jiang, W.D., Liu, Y., Kai, H., Jiang, J., Li, S.H., Feng, L., Zhou, X.Q. (2014). Copper exposure induces oxidative injury, disturbs the antioxidant system and changes the Nrf/ARE (CuZnSOD) signaling in the fish brain: protective effect of myo-inositol. Aquatic toxicology, 155C, 301-313.
  • 37. Danyelle, T.M., Kanneth, T.D. (2003). The role of glutathion S-transferase in anti-cancer drug resistance. Oncogene, 22(47), 7369-75.
  • 38. Miller, A.L. (1998). Botanical influences on cardiovascular disease. Alternative Medicine Review, 3, 422-431.
  • 39. Ju, L.Y. (2005). Crataegus oxyacantha (aubepine) in the use as herb medicine in France. Zhongguo Zhong Yao ZaZhi, 30(8), 634-40.
  • 40. Rosario, G.M., Emmanuel, I.E., Raúl, N.A. (2013). Antioxidant compounds in hawthorn fruits (Crataegus spp.) of Mexico. Revista Mexicana de Biodiversidad, 84(4), 1298-1304.
  • 41. Yousef, M.I., Abdullah, G.A., Kamel, I. (2003). Effect of ascorbic acid and vitamin E supplementation on semen quality and biochemical parameters of male rabbits. Animal Reproduction Science, 76(1-2), 99-111.
  • 42. Agarwal, A., Nallella, K.P., Allamaneni, S.S. (2004). Said TM. Role of antioxidants in treatment of male infertility: an overview of the literature. Reproductive biomedicine online, 8(6), 616-27.
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There are 51 citations in total.

Details

Primary Language English
Subjects Pharmacology and Pharmaceutical Sciences
Journal Section Research Article
Authors

Feriel Remıta 0000-0002-4847-1309

Cherif Abdennour This is me 0000-0003-1048-3854

Amina Talbı 0000-0002-4235-366X

Kamel Khelılı This is me 0000-0001-7160-5451

Project Number number 06/2016, recipient C. ABDENNOUR
Publication Date September 30, 2020
Submission Date April 7, 2020
Acceptance Date September 14, 2020
Published in Issue Year 2020

Cite

APA Remıta, F., Abdennour, C., Talbı, A., Khelılı, K. (2020). PROTECTIVE ROLE OF CRATAEGUS MONOGYNA ON SPERM QUALITY AND TESTIS OXIDATIVE STRESS AGAINST COPPER-INDUCED TOXICITY. Journal of Faculty of Pharmacy of Ankara University, 44(3), 452-469. https://doi.org/10.33483/jfpau.716103
AMA Remıta F, Abdennour C, Talbı A, Khelılı K. PROTECTIVE ROLE OF CRATAEGUS MONOGYNA ON SPERM QUALITY AND TESTIS OXIDATIVE STRESS AGAINST COPPER-INDUCED TOXICITY. Ankara Ecz. Fak. Derg. September 2020;44(3):452-469. doi:10.33483/jfpau.716103
Chicago Remıta, Feriel, Cherif Abdennour, Amina Talbı, and Kamel Khelılı. “PROTECTIVE ROLE OF CRATAEGUS MONOGYNA ON SPERM QUALITY AND TESTIS OXIDATIVE STRESS AGAINST COPPER-INDUCED TOXICITY”. Journal of Faculty of Pharmacy of Ankara University 44, no. 3 (September 2020): 452-69. https://doi.org/10.33483/jfpau.716103.
EndNote Remıta F, Abdennour C, Talbı A, Khelılı K (September 1, 2020) PROTECTIVE ROLE OF CRATAEGUS MONOGYNA ON SPERM QUALITY AND TESTIS OXIDATIVE STRESS AGAINST COPPER-INDUCED TOXICITY. Journal of Faculty of Pharmacy of Ankara University 44 3 452–469.
IEEE F. Remıta, C. Abdennour, A. Talbı, and K. Khelılı, “PROTECTIVE ROLE OF CRATAEGUS MONOGYNA ON SPERM QUALITY AND TESTIS OXIDATIVE STRESS AGAINST COPPER-INDUCED TOXICITY”, Ankara Ecz. Fak. Derg., vol. 44, no. 3, pp. 452–469, 2020, doi: 10.33483/jfpau.716103.
ISNAD Remıta, Feriel et al. “PROTECTIVE ROLE OF CRATAEGUS MONOGYNA ON SPERM QUALITY AND TESTIS OXIDATIVE STRESS AGAINST COPPER-INDUCED TOXICITY”. Journal of Faculty of Pharmacy of Ankara University 44/3 (September 2020), 452-469. https://doi.org/10.33483/jfpau.716103.
JAMA Remıta F, Abdennour C, Talbı A, Khelılı K. PROTECTIVE ROLE OF CRATAEGUS MONOGYNA ON SPERM QUALITY AND TESTIS OXIDATIVE STRESS AGAINST COPPER-INDUCED TOXICITY. Ankara Ecz. Fak. Derg. 2020;44:452–469.
MLA Remıta, Feriel et al. “PROTECTIVE ROLE OF CRATAEGUS MONOGYNA ON SPERM QUALITY AND TESTIS OXIDATIVE STRESS AGAINST COPPER-INDUCED TOXICITY”. Journal of Faculty of Pharmacy of Ankara University, vol. 44, no. 3, 2020, pp. 452-69, doi:10.33483/jfpau.716103.
Vancouver Remıta F, Abdennour C, Talbı A, Khelılı K. PROTECTIVE ROLE OF CRATAEGUS MONOGYNA ON SPERM QUALITY AND TESTIS OXIDATIVE STRESS AGAINST COPPER-INDUCED TOXICITY. Ankara Ecz. Fak. Derg. 2020;44(3):452-69.

Kapsam ve Amaç

Ankara Üniversitesi Eczacılık Fakültesi Dergisi, açık erişim, hakemli bir dergi olup Türkçe veya İngilizce olarak farmasötik bilimler alanındaki önemli gelişmeleri içeren orijinal araştırmalar, derlemeler ve kısa bildiriler için uluslararası bir yayım ortamıdır. Bilimsel toplantılarda sunulan bildiriler supleman özel sayısı olarak dergide yayımlanabilir. Ayrıca, tüm farmasötik alandaki gelecek ve önceki ulusal ve uluslararası bilimsel toplantılar ile sosyal aktiviteleri içerir.