ORGANİK REAKSİYONLARDA METAL İÇERMEYEN KATALİZÖR KULLANILARAK İNDOL TÜREVLERİNİN SENTEZİ

Abstract

Amaç: İndol türevleri azot bazlı iskeletlerden biridir ve biyolojik veya tıbbi önemi olan birçok heterosiklik bileşiğin sentezinde sıklıkla kullanılır. Birçok indol türevi bitkilerden, mantarlardan ve deniz organizmalarından doğal olarak izole edilmiştir ve farmasötik aktiviteleri nedeniyle oldukça önemlidirler. Ayrıca polimer ve boya endüstrilerinde ve tarım sektöründe de önemli rol oynarlar. İstenen kimyasal ve biyomedikal özelliklere sahip indol bazlı heterosiklik iskelet yapısının sentezi için tasarım ve metodoloji geliştirmeye ihtiyaç vardır.

Sonuç ve Tartışma: Bu derlemede, çeşitli heterosiklik yapı iskeletlerinin hazırlanması için metal içermeyen katalizörlerin kullanıldığı, tek kap çok bileşenli reaksiyonlarla indollerin son uygulamaları özetlenmiştir ve bunlara karşılık gelen biyolojik aktiviteler tartışılmıştır.

Keywords

• Indol türevleri
• metalsiz katalizör
• sentez
• tek potalı çok bileşenli reaksiyon

SYNTHESIS OF INDOLES DERIVATIVES USING METAL FREE CATALYST IN ORGANIC REACTIONS

Abstract

Objective: Indole derivatives are one of the most flexible and common nitrogen-based skeletons and often used in the synthesis of numerous heterocyclic compounds, having biological or medicinal importance. Many indole derivatives have been isolated naturally from plants, fungi, and marine organisms and are highly important due to their pharmaceutical activities. They also play a significant character in polymer and dye industries as well as in the agriculture sector. There exists an immense potential for designing and methodology development for the synthesis of indole based heterocyclic scaffold structure with desire chemical and biomedical relevance.

Result and Discussion: In this present review, we outlined the recent applications of indoles in the one-pot multi-component reaction using metal free catalysts for the preparation of various heterocyclic scaffolds and their corresponding biological activities are also discussed.

Keywords

• Indole derivatives
• metal free catalyst
• one pot multi-component reaction
• synthesis

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