THE INHIBITORY EFFECTS OF THIAZOLYL-2,4- THIAZOLIDINEDIONE COMPOUNDS ON THE RAT KIDNEY ALDOSE REDUCTASE ENZYME

Meltem Ceylan Ünlüsoy; Net Das Evcimen; Mutlu Sarıkaya; Oya Bozdağ Dündar; Rahmiye Ertan

doi:10.1501/Eczfak_0000000526

The inhibitory effects of thiazolyl-2,4 thiazolidinedione compounds on the rat kidney aldose reductase enzyme

Year 2009, Volume: 38 Issue: 3, 181 - 190, 01.09.2009

Meltem Ceylan Ünlüsoy Net Das Evcimen Mutlu Sarıkaya Oya Bozdağ Dündar Rahmiye Ertan

https://doi.org/10.1501/Eczfak_0000000526

Abstract

Aldoz redüktaz enzimi glukozun sorbitole indirgenmesi reaksiyonunda anahtar rol oynamaktadır. Sorbitolün birikimi diyabette, diyabetik katarakt, retinopati, nöropati ve nefropati gibi komplikasyonlara neden olmaktadır. Aldoz redüktaz inhibitörlerinin dokularda sorbitol birikimini önlediği gösterilmiştir. Aldoz redüktaz enziminin inhibisyonunun farmakolojik profilini geliştirmek amacı ile çok sayıda bileşik geliştirilmiştir. Bu çalışmada, tiyazolil-2,4-tiyazolidindion serilerinin (Ia-f, IIa-f and IIIa-f) aldoz redüktaz inhibitör aktiviteleri test edilmiştir. Substitüe-tiyazolil-tiyazolidindion türevlerinin çok az düzeyde inhibitör aktiviteleri olduğu tespit edilmiştir

Keywords

2, 4-Tiyazolidindionlar, Tiyazol Türevleri, Aldoz Redüktaz Enzimi, İnhibisyon, Diyabet

THE INHIBITORY EFFECTS OF THIAZOLYL-2,4- THIAZOLIDINEDIONE COMPOUNDS ON THE RAT KIDNEY ALDOSE REDUCTASE ENZYME

Year 2009, Volume: 38 Issue: 3, 181 - 190, 01.09.2009

Meltem Ceylan Ünlüsoy Net Das Evcimen Mutlu Sarıkaya Oya Bozdağ Dündar Rahmiye Ertan

https://doi.org/10.1501/Eczfak_0000000526

Abstract

Aldose reductase enzyme is the key factor in the reduction of glucose to sorbitol. Accumulation of sorbitol in diabetes causes complications such as diabetic cataract, retinopathy, neuropathy and nephropathy. Aldose reductase inhibitors have been found to prevent sorbitol accumulation in tissues. Numerous compounds have been prepared in order to improve the pharmacological profile of inhibition of aldose reductase enzyme. In this study, series of thiazolyl-2,4-thiazolidinediones (Ia-f, IIa-f and IIIa-f) were tested for their aldose reductase inhibitory activities. It was found that substituted-thiazolyl-thiazolidinedione derivatives showing very slight inhibitor activity

Keywords

2, 4-Thiazolidinediones, Thiazole derivatives, Aldose reductase enzyme, Inhibition, Diabetes

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Details

Other ID	JA95FP28MN
Journal Section	Research Article
Authors	Meltem Ceylan Ünlüsoy This is me Net Das Evcimen This is me Mutlu Sarıkaya This is me Oya Bozdağ Dündar This is me Rahmiye Ertan This is me
Publication Date	September 1, 2009
Submission Date	September 1, 2009
Published in Issue	Year 2009 Volume: 38 Issue: 3

Cite

APA	Ceylan Ünlüsoy, M., Das Evcimen, N., Sarıkaya, M., Bozdağ Dündar, O., et al. (2009). THE INHIBITORY EFFECTS OF THIAZOLYL-2,4- THIAZOLIDINEDIONE COMPOUNDS ON THE RAT KIDNEY ALDOSE REDUCTASE ENZYME. Journal of Faculty of Pharmacy of Ankara University, 38(3), 181-190. https://doi.org/10.1501/Eczfak_0000000526
AMA	Ceylan Ünlüsoy M, Das Evcimen N, Sarıkaya M, Bozdağ Dündar O, Ertan R. THE INHIBITORY EFFECTS OF THIAZOLYL-2,4- THIAZOLIDINEDIONE COMPOUNDS ON THE RAT KIDNEY ALDOSE REDUCTASE ENZYME. J. Fac. Pharm. Ankara. September 2009;38(3):181-190. doi:10.1501/Eczfak_0000000526
Chicago	Ceylan Ünlüsoy, Meltem, Net Das Evcimen, Mutlu Sarıkaya, Oya Bozdağ Dündar, and Rahmiye Ertan. “THE INHIBITORY EFFECTS OF THIAZOLYL-2,4- THIAZOLIDINEDIONE COMPOUNDS ON THE RAT KIDNEY ALDOSE REDUCTASE ENZYME”. Journal of Faculty of Pharmacy of Ankara University 38, no. 3 (September 2009): 181-90. https://doi.org/10.1501/Eczfak_0000000526.
EndNote	Ceylan Ünlüsoy M, Das Evcimen N, Sarıkaya M, Bozdağ Dündar O, Ertan R (September 1, 2009) THE INHIBITORY EFFECTS OF THIAZOLYL-2,4- THIAZOLIDINEDIONE COMPOUNDS ON THE RAT KIDNEY ALDOSE REDUCTASE ENZYME. Journal of Faculty of Pharmacy of Ankara University 38 3 181–190.
IEEE	M. Ceylan Ünlüsoy, N. Das Evcimen, M. Sarıkaya, O. Bozdağ Dündar, and R. Ertan, “THE INHIBITORY EFFECTS OF THIAZOLYL-2,4- THIAZOLIDINEDIONE COMPOUNDS ON THE RAT KIDNEY ALDOSE REDUCTASE ENZYME”, J. Fac. Pharm. Ankara, vol. 38, no. 3, pp. 181–190, 2009, doi: 10.1501/Eczfak_0000000526.
ISNAD	Ceylan Ünlüsoy, Meltem et al. “THE INHIBITORY EFFECTS OF THIAZOLYL-2,4- THIAZOLIDINEDIONE COMPOUNDS ON THE RAT KIDNEY ALDOSE REDUCTASE ENZYME”. Journal of Faculty of Pharmacy of Ankara University 38/3 (September 2009), 181-190. https://doi.org/10.1501/Eczfak_0000000526.
JAMA	Ceylan Ünlüsoy M, Das Evcimen N, Sarıkaya M, Bozdağ Dündar O, Ertan R. THE INHIBITORY EFFECTS OF THIAZOLYL-2,4- THIAZOLIDINEDIONE COMPOUNDS ON THE RAT KIDNEY ALDOSE REDUCTASE ENZYME. J. Fac. Pharm. Ankara. 2009;38:181–190.
MLA	Ceylan Ünlüsoy, Meltem et al. “THE INHIBITORY EFFECTS OF THIAZOLYL-2,4- THIAZOLIDINEDIONE COMPOUNDS ON THE RAT KIDNEY ALDOSE REDUCTASE ENZYME”. Journal of Faculty of Pharmacy of Ankara University, vol. 38, no. 3, 2009, pp. 181-90, doi:10.1501/Eczfak_0000000526.
Vancouver	Ceylan Ünlüsoy M, Das Evcimen N, Sarıkaya M, Bozdağ Dündar O, Ertan R. THE INHIBITORY EFFECTS OF THIAZOLYL-2,4- THIAZOLIDINEDIONE COMPOUNDS ON THE RAT KIDNEY ALDOSE REDUCTASE ENZYME. J. Fac. Pharm. Ankara. 2009;38(3):181-90.

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The Journal of Faculty of Pharmacy of Ankara University is an international medium, an open access, peer-reviewed journal for the publication of original research reports, reviews and short communications in English or Turkish on relevant developments in pharmaceutical sciences., Proceeding of scientific meetings may be published as special issues of supplements to the journal. Additionally, it contains previous and forthcoming national and international scientific meetings with social activities in pharmaceutical areas.